ATE314352T1 - Anilide als acat-hemmer - Google Patents

Anilide als acat-hemmer

Info

Publication number
ATE314352T1
ATE314352T1 AT97108154T AT97108154T ATE314352T1 AT E314352 T1 ATE314352 T1 AT E314352T1 AT 97108154 T AT97108154 T AT 97108154T AT 97108154 T AT97108154 T AT 97108154T AT E314352 T1 ATE314352 T1 AT E314352T1
Authority
AT
Austria
Prior art keywords
group
oxygen
compounds
optionally
pharmaceutical compositions
Prior art date
Application number
AT97108154T
Other languages
English (en)
Inventor
Kimiyuki Lions Hills Shibuya
Tokorozawa-Shi Kamiarai
Katsumi Kawamine
Cho
Yukihiro Sato
Toshiyuki Edano
Souhei Tanabe
Masami Shiratsuchi
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Application granted granted Critical
Publication of ATE314352T1 publication Critical patent/ATE314352T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97108154T 1996-05-17 1997-05-20 Anilide als acat-hemmer ATE314352T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15874396 1996-05-17
JP08866097A JP4191269B2 (ja) 1996-05-17 1997-03-25 新規なアニリド化合物及びこれを含有する医薬

Publications (1)

Publication Number Publication Date
ATE314352T1 true ATE314352T1 (de) 2006-01-15

Family

ID=26430018

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97108154T ATE314352T1 (de) 1996-05-17 1997-05-20 Anilide als acat-hemmer

Country Status (7)

Country Link
US (2) US6204278B1 (de)
EP (1) EP0807627B1 (de)
JP (1) JP4191269B2 (de)
AT (1) ATE314352T1 (de)
DE (1) DE69734952T2 (de)
DK (1) DK0807627T3 (de)
ES (1) ES2252765T3 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE297900T1 (de) * 1997-03-25 2005-07-15 Kowa Co Anilidverbindungen und medikamente, die diese enthalten
US6969711B2 (en) 1997-05-26 2005-11-29 Kowa Company, Ltd. Cyclic diamine compounds and medicine containing the same
EP0987254B1 (de) * 1997-05-26 2004-12-22 Kowa Co., Ltd. Neue zyklische diaminverbindungen und heilmittel das diese enthält
ES2262248T3 (es) * 1997-11-14 2006-11-16 Kowa Company. Ltd. Nuevos compuestos amida y medicamente que los contienen.
US6849647B1 (en) 1999-07-21 2005-02-01 Kowa Company, Ltd. Amide compounds and medications containing the same technical field
JP4592130B2 (ja) * 1999-08-05 2010-12-01 大塚化学株式会社 チオ酢酸アミド化合物及び農園芸用殺菌剤
US6622484B2 (en) 2001-02-02 2003-09-23 Caterpillar Inc. Hystat/split torque modulation
JP4242765B2 (ja) * 2001-08-22 2009-03-25 興和株式会社 血管壁選択的なａｃａｔ阻害剤
US7163944B2 (en) * 2004-01-26 2007-01-16 Kowa Co., Ltd. Cyclic diamine compound and pharmaceutical containing the same
DK1809759T3 (da) 2004-10-06 2014-01-06 Brigham & Womens Hospital Relevans af opnåede niveauer af markører for systemisk inflammation efter behandling
US8633233B2 (en) 2008-08-06 2014-01-21 Hydra Biosciences, Inc. Methods and compositions for treating anxiety
JP5523993B2 (ja) 2010-08-31 2014-06-18 富士フイルム株式会社 酸ハロゲン化物の製造方法、及び酸ハロゲン化物
CN105143229B (zh) 2013-03-15 2017-06-30 海德拉生物科学有限公司 取代的黄嘌呤及其使用方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB921791A (en) * 1960-01-21 1963-03-27 Ici Ltd New dyestuffs
US3720686A (en) 1971-04-01 1973-03-13 Squibb & Sons Inc Mercaptobenzimidazole derivatives
EP0005501B1 (de) * 1978-05-20 1981-11-25 Bayer Ag Heteroaryl-oxyessigsäureamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide
DE2903966A1 (de) 1979-02-02 1980-08-07 Bayer Ag Substituierte carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
AU541738B2 (en) 1979-09-20 1985-01-17 Nippon Chemiphar Co. Ltd. Cyclohexane carboxylic acid derivatives
GB2093835B (en) 1981-01-22 1984-10-31 Nippon Chemiphar Co Novel guanidinocyclohexanecarboxylic acid derivatives and a process for producing the same
DE3419994A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Benzoxazolyl- und benzthiazolyl-aminosaeuren, ihre herstellung und verwendung im pflanzenschutz
CA2003283A1 (en) 1988-12-05 1990-06-05 C. Anne Higley Imidazoles for the treatment of atherosclerosis
MX22406A (es) 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
US5668136A (en) 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
JPH04139172A (ja) * 1990-10-01 1992-05-13 Sankyo Co Ltd α―スルフィニル置換アセトアミド誘導体
US5362878A (en) 1991-03-21 1994-11-08 Pfizer Inc. Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
US5364875A (en) 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5290801A (en) * 1992-05-29 1994-03-01 The Du Pont Merck Pharmaceutical Company Benzimidazoles for the treatment of atherosclerosis
JP2000510164A (ja) * 1997-02-14 2000-08-08 バイエル・コーポレーシヨン 選択的神経ペプチドｙ受容体アンタゴニストとしてのアミド誘導体

Also Published As

Publication number Publication date
EP0807627B1 (de) 2005-12-28
EP0807627A3 (de) 1997-12-03
EP0807627A2 (de) 1997-11-19
US6204278B1 (en) 2001-03-20
ES2252765T3 (es) 2006-05-16
US6825223B2 (en) 2004-11-30
US20020037910A1 (en) 2002-03-28
DE69734952T2 (de) 2006-07-27
DK0807627T3 (da) 2006-04-10
DE69734952D1 (de) 2006-02-02
JPH1029986A (ja) 1998-02-03
JP4191269B2 (ja) 2008-12-03

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