DK0807627T3 - Anilidforbindelser som ACAT-inhibitorer - Google Patents
Anilidforbindelser som ACAT-inhibitorerInfo
- Publication number
- DK0807627T3 DK0807627T3 DK97108154T DK97108154T DK0807627T3 DK 0807627 T3 DK0807627 T3 DK 0807627T3 DK 97108154 T DK97108154 T DK 97108154T DK 97108154 T DK97108154 T DK 97108154T DK 0807627 T3 DK0807627 T3 DK 0807627T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- group
- oxygen
- optionally
- pharmaceutical compositions
- Prior art date
Links
- -1 Anilide compounds Chemical class 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 125000004434 sulfur atom Chemical group 0.000 abstract 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005516 coenzyme A Substances 0.000 abstract 1
- 229940093530 coenzyme a Drugs 0.000 abstract 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001174 sulfone group Chemical group 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15874396 | 1996-05-17 | ||
| JP08866097A JP4191269B2 (ja) | 1996-05-17 | 1997-03-25 | 新規なアニリド化合物及びこれを含有する医薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0807627T3 true DK0807627T3 (da) | 2006-04-10 |
Family
ID=26430018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97108154T DK0807627T3 (da) | 1996-05-17 | 1997-05-20 | Anilidforbindelser som ACAT-inhibitorer |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6204278B1 (da) |
| EP (1) | EP0807627B1 (da) |
| JP (1) | JP4191269B2 (da) |
| AT (1) | ATE314352T1 (da) |
| DE (1) | DE69734952T2 (da) |
| DK (1) | DK0807627T3 (da) |
| ES (1) | ES2252765T3 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE297900T1 (de) * | 1997-03-25 | 2005-07-15 | Kowa Co | Anilidverbindungen und medikamente, die diese enthalten |
| US6969711B2 (en) | 1997-05-26 | 2005-11-29 | Kowa Company, Ltd. | Cyclic diamine compounds and medicine containing the same |
| WO1998054153A1 (en) * | 1997-05-26 | 1998-12-03 | Kowa Company, Ltd. | Novel cyclic diamine compounds and medicine containing the same |
| JP4402176B2 (ja) * | 1997-11-14 | 2010-01-20 | 興和株式会社 | 新規アミド化合物及びこれを含有する医薬 |
| US6849647B1 (en) | 1999-07-21 | 2005-02-01 | Kowa Company, Ltd. | Amide compounds and medications containing the same technical field |
| JP4592130B2 (ja) * | 1999-08-05 | 2010-12-01 | 大塚化学株式会社 | チオ酢酸アミド化合物及び農園芸用殺菌剤 |
| US6622484B2 (en) | 2001-02-02 | 2003-09-23 | Caterpillar Inc. | Hystat/split torque modulation |
| WO2003018564A1 (en) * | 2001-08-22 | 2003-03-06 | Kowa Company, Ltd | Vascular wall-selective acat inhibitor |
| US7163944B2 (en) * | 2004-01-26 | 2007-01-16 | Kowa Co., Ltd. | Cyclic diamine compound and pharmaceutical containing the same |
| AU2005294165B2 (en) | 2004-10-06 | 2012-02-02 | The Brigham And Women's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
| US8633233B2 (en) | 2008-08-06 | 2014-01-21 | Hydra Biosciences, Inc. | Methods and compositions for treating anxiety |
| JP5523993B2 (ja) | 2010-08-31 | 2014-06-18 | 富士フイルム株式会社 | 酸ハロゲン化物の製造方法、及び酸ハロゲン化物 |
| NZ711718A (en) | 2013-03-15 | 2020-05-29 | Hydra Biosciences Llc | Substituted xanthines and methods of use thereof |
| WO2025194116A1 (en) * | 2024-03-15 | 2025-09-18 | The Regents Of The University Of California | Pcsk9 inhibitors and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB921791A (en) * | 1960-01-21 | 1963-03-27 | Ici Ltd | New dyestuffs |
| US3720686A (en) | 1971-04-01 | 1973-03-13 | Squibb & Sons Inc | Mercaptobenzimidazole derivatives |
| DE2903966A1 (de) | 1979-02-02 | 1980-08-07 | Bayer Ag | Substituierte carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
| DE2961415D1 (en) * | 1978-05-20 | 1982-01-28 | Bayer Ag | Heteroaryloxy-acetamides, process for their preparation and their use as herbicides |
| SE460667B (sv) | 1979-09-20 | 1989-11-06 | Nippon Chemiphar Co | Cyklohexankarboxylsyraderivat, foerfarande foer framstaellning daerav samt naemnda derivat foer terapeutisk anvaendning |
| GB2093835B (en) | 1981-01-22 | 1984-10-31 | Nippon Chemiphar Co | Novel guanidinocyclohexanecarboxylic acid derivatives and a process for producing the same |
| DE3419994A1 (de) * | 1984-05-29 | 1985-12-05 | Hoechst Ag, 6230 Frankfurt | Benzoxazolyl- und benzthiazolyl-aminosaeuren, ihre herstellung und verwendung im pflanzenschutz |
| CA2003283A1 (en) | 1988-12-05 | 1990-06-05 | C. Anne Higley | Imidazoles for the treatment of atherosclerosis |
| WO1991004027A1 (en) | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| US5668136A (en) | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| JPH04139172A (ja) * | 1990-10-01 | 1992-05-13 | Sankyo Co Ltd | α―スルフィニル置換アセトアミド誘導体 |
| US5362878A (en) | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
| US5364875A (en) | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
| US5290801A (en) * | 1992-05-29 | 1994-03-01 | The Du Pont Merck Pharmaceutical Company | Benzimidazoles for the treatment of atherosclerosis |
| EP0910565A1 (en) * | 1997-02-14 | 1999-04-28 | Bayer Corporation | Amide derivatives as selective neuropeptide y receptor antagonists |
-
1997
- 1997-03-25 JP JP08866097A patent/JP4191269B2/ja not_active Expired - Lifetime
- 1997-05-19 US US08/858,244 patent/US6204278B1/en not_active Expired - Fee Related
- 1997-05-20 DK DK97108154T patent/DK0807627T3/da active
- 1997-05-20 EP EP97108154A patent/EP0807627B1/en not_active Expired - Lifetime
- 1997-05-20 DE DE69734952T patent/DE69734952T2/de not_active Expired - Lifetime
- 1997-05-20 AT AT97108154T patent/ATE314352T1/de not_active IP Right Cessation
- 1997-05-20 ES ES97108154T patent/ES2252765T3/es not_active Expired - Lifetime
-
2001
- 2001-02-21 US US09/789,967 patent/US6825223B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0807627A2 (en) | 1997-11-19 |
| US20020037910A1 (en) | 2002-03-28 |
| ATE314352T1 (de) | 2006-01-15 |
| EP0807627B1 (en) | 2005-12-28 |
| DE69734952D1 (de) | 2006-02-02 |
| ES2252765T3 (es) | 2006-05-16 |
| DE69734952T2 (de) | 2006-07-27 |
| JP4191269B2 (ja) | 2008-12-03 |
| JPH1029986A (ja) | 1998-02-03 |
| EP0807627A3 (en) | 1997-12-03 |
| US6825223B2 (en) | 2004-11-30 |
| US6204278B1 (en) | 2001-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1424330T3 (da) | Aktivator for peroxisom proliferator-responsiv receptor delta | |
| PT987254E (pt) | Compostos de diamina ciclica, originais, e medicamentos que os contem | |
| DK0807627T3 (da) | Anilidforbindelser som ACAT-inhibitorer | |
| IL120266A (en) | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions | |
| DK0842661T3 (da) | Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning | |
| FI920271A0 (fi) | Polyamintioler som straolningsskyddande aemnen. | |
| DK0918776T3 (da) | Totalsyntese af antitumor acylfulvener | |
| FI971227A0 (fi) | Pyramidinyylipyratsolijohdannaisia | |
| DE60223904D1 (de) | Benzylaminanalogen | |
| ATE372320T1 (de) | Cyclische amidderivate | |
| EP1306369A4 (en) | NEW SULFUR COMPOUNDS AND INTERMOLECULAR COMPOUNDS CONTAINING THEM AS A COMPONENT | |
| SE8303913L (sv) | Heterocykliska foreningar | |
| AU6517698A (en) | Novel anilide compounds and drugs containing the same |