EA200200665A1 - NEW COMPOUNDS OF BENZOLSULFONAMIDE, METHOD OF THEIR RECEIVING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
NEW COMPOUNDS OF BENZOLSULFONAMIDE, METHOD OF THEIR RECEIVING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- EA200200665A1 EA200200665A1 EA200200665A EA200200665A EA200200665A1 EA 200200665 A1 EA200200665 A1 EA 200200665A1 EA 200200665 A EA200200665 A EA 200200665A EA 200200665 A EA200200665 A EA 200200665A EA 200200665 A1 EA200200665 A1 EA 200200665A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- benzolsulfonamide
- receiving
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Соединение формулы (I)в которой Rпредставляет собой гидрокси, алкокси, арилокси или арилалкилоксигруппу,А представляет собой группу СН атом азота, в в этом случае Rимеет значение, указанное в описании, или R-A совместно представляют собой атом кислорода или группув которой Rи Rимеют значения, указанные в описании,Rпредставляет собой атом водорода или алкильную группу,Rи R, которые могут быть одинаковыми или различными, каждый представляет собой атом водорода, атом галогена, алкильную группу, алкоксигруппу, гидроксигруппу или тригалоалкильную группу,n представляет собой целое число от 2 до 6 включительно,m и р представляют собой целые числа от 0 до 6 включительно.Лекарственные препараты.The compound of formula (I) in which R1 is a hydroxy, alkoxy, aryloxy or arylalkyloxy group, A represents the CH group nitrogen atom, in this case R1 has the meaning specified in the description, or RA together represent an oxygen atom or groups of which R1 and R7 have the values as indicated in the description, R1 is a hydrogen atom or an alkyl group, R1 and R4, which may be the same or different, each represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, a hydroxy group or a trihaloalkyl group group, n is an integer from 2 to 6 inclusive, m and p are integers from 0 to 6 inclusive. Medications.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0109338A FR2827287B1 (en) | 2001-07-13 | 2001-07-13 | NOVEL BENZENE SULFONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200200665A1 true EA200200665A1 (en) | 2003-02-27 |
EA005403B1 EA005403B1 (en) | 2005-02-24 |
Family
ID=8865461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200665A EA005403B1 (en) | 2001-07-13 | 2002-07-12 | Benzenesulfonamide compounds, a process for their preparation and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
US (1) | US6589956B2 (en) |
EP (1) | EP1275644A1 (en) |
JP (1) | JP4138382B2 (en) |
KR (1) | KR100498864B1 (en) |
CN (1) | CN1168715C (en) |
AR (1) | AR036340A1 (en) |
AU (1) | AU2002300093B2 (en) |
BR (1) | BR0202674A (en) |
CA (1) | CA2394037C (en) |
EA (1) | EA005403B1 (en) |
FR (1) | FR2827287B1 (en) |
HK (1) | HK1050681A1 (en) |
HU (1) | HUP0202286A2 (en) |
MX (1) | MXPA02006852A (en) |
NO (1) | NO323868B1 (en) |
NZ (1) | NZ520140A (en) |
PL (1) | PL354948A1 (en) |
ZA (1) | ZA200205598B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4324221B2 (en) * | 2005-08-26 | 2009-09-02 | 株式会社医薬分子設計研究所 | Derivatives having PPAR agonist activity |
US10093640B2 (en) | 2012-09-21 | 2018-10-09 | Vanderbilt University | Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors |
EP3038618B1 (en) | 2013-08-28 | 2020-10-14 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
CN106456602B (en) | 2014-03-27 | 2020-11-24 | 范德比尔特大学 | Substituted indole MCL-1 inhibitors |
US9949965B2 (en) | 2014-10-17 | 2018-04-24 | Vanderbilt University | Tricyclic indole Mcl-1 inhibitors and uses thereof |
KR102396177B1 (en) | 2016-03-04 | 2022-05-09 | 반더빌트유니버시티 | Substituted indole MCL-1 inhibitors |
TW202136235A (en) * | 2019-12-24 | 2021-10-01 | 日商大日本住友製藥股份有限公司 | Aliphatic amide derivative |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3468882A (en) * | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
GB8419575D0 (en) * | 1984-08-01 | 1984-09-05 | Glaxo Group Ltd | Chemical compounds |
KR940007458B1 (en) * | 1991-11-21 | 1994-08-18 | 주식회사 금성사 | Manufacturing method of thin film transistor |
TW219358B (en) * | 1991-12-20 | 1994-01-21 | Hokuriku Pharmaceutical | |
WO1994014769A1 (en) * | 1992-12-21 | 1994-07-07 | Taisho Pharmaceutical Co., Ltd. | N-substituted indole derivative |
GB9317764D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
FR2712591B1 (en) * | 1993-11-19 | 1996-02-09 | Pf Medicament | New arylpiperazines derived from indole, their preparation and their therapeutic use. |
AU714054B2 (en) * | 1995-01-06 | 1999-12-16 | Toray Industries, Inc. | Benzene-fused heterocyclic derivatives and use of the same |
US5998415A (en) * | 1995-11-02 | 1999-12-07 | Merck Sharp & Dohme Ltd. | Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors |
GB9523250D0 (en) * | 1995-11-14 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
GB9523243D0 (en) * | 1995-11-14 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
-
2001
- 2001-07-13 FR FR0109338A patent/FR2827287B1/en not_active Expired - Fee Related
-
2002
- 2002-07-08 PL PL02354948A patent/PL354948A1/en not_active Application Discontinuation
- 2002-07-10 BR BR0202674-0A patent/BR0202674A/en not_active IP Right Cessation
- 2002-07-10 JP JP2002200910A patent/JP4138382B2/en not_active Expired - Fee Related
- 2002-07-11 MX MXPA02006852A patent/MXPA02006852A/en active IP Right Grant
- 2002-07-11 EP EP02291746A patent/EP1275644A1/en not_active Withdrawn
- 2002-07-12 EA EA200200665A patent/EA005403B1/en not_active IP Right Cessation
- 2002-07-12 AU AU2002300093A patent/AU2002300093B2/en not_active Ceased
- 2002-07-12 AR ARP020102608A patent/AR036340A1/en not_active Application Discontinuation
- 2002-07-12 ZA ZA200205598A patent/ZA200205598B/en unknown
- 2002-07-12 NO NO20023389A patent/NO323868B1/en not_active IP Right Cessation
- 2002-07-12 NZ NZ520140A patent/NZ520140A/en unknown
- 2002-07-12 HU HU0202286A patent/HUP0202286A2/en unknown
- 2002-07-12 US US10/195,031 patent/US6589956B2/en not_active Expired - Fee Related
- 2002-07-13 KR KR10-2002-0040945A patent/KR100498864B1/en not_active IP Right Cessation
- 2002-07-15 CA CA002394037A patent/CA2394037C/en not_active Expired - Fee Related
- 2002-07-15 CN CNB021241619A patent/CN1168715C/en not_active Expired - Fee Related
-
2003
- 2003-04-17 HK HK03102798A patent/HK1050681A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2394037C (en) | 2008-04-29 |
BR0202674A (en) | 2003-05-06 |
JP4138382B2 (en) | 2008-08-27 |
NO20023389L (en) | 2003-01-14 |
US6589956B2 (en) | 2003-07-08 |
AR036340A1 (en) | 2004-09-01 |
PL354948A1 (en) | 2003-01-27 |
HUP0202286A2 (en) | 2003-08-28 |
EA005403B1 (en) | 2005-02-24 |
AU2002300093B2 (en) | 2007-07-12 |
MXPA02006852A (en) | 2005-07-25 |
US20030109533A1 (en) | 2003-06-12 |
ZA200205598B (en) | 2003-03-27 |
KR20030007173A (en) | 2003-01-23 |
HU0202286D0 (en) | 2002-09-28 |
NO20023389D0 (en) | 2002-07-12 |
FR2827287B1 (en) | 2003-10-31 |
NZ520140A (en) | 2003-09-26 |
HK1050681A1 (en) | 2003-07-04 |
CN1397550A (en) | 2003-02-19 |
NO323868B1 (en) | 2007-07-16 |
CN1168715C (en) | 2004-09-29 |
KR100498864B1 (en) | 2005-07-04 |
CA2394037A1 (en) | 2003-01-13 |
JP2003064055A (en) | 2003-03-05 |
EP1275644A1 (en) | 2003-01-15 |
FR2827287A1 (en) | 2003-01-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |