ATE502005T1 - Amphotere lipidverbindung und deren verwendung - Google Patents

Amphotere lipidverbindung und deren verwendung

Info

Publication number
ATE502005T1
ATE502005T1 AT02796353T AT02796353T ATE502005T1 AT E502005 T1 ATE502005 T1 AT E502005T1 AT 02796353 T AT02796353 T AT 02796353T AT 02796353 T AT02796353 T AT 02796353T AT E502005 T1 ATE502005 T1 AT E502005T1
Authority
AT
Austria
Prior art keywords
amphoterelic
lipid compound
formula
lipid
compound
Prior art date
Application number
AT02796353T
Other languages
English (en)
Inventor
Eishun Tsuchida
Shinji Takeoka
Keitaro Sou
Katsura Mori
Original Assignee
Japan Chem Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Chem Res filed Critical Japan Chem Res
Application granted granted Critical
Publication of ATE502005T1 publication Critical patent/ATE502005T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06104Dipeptides with the first amino acid being acidic
    • C07K5/06113Asp- or Asn-amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41Porphyrin- or corrin-ring-containing peptides
    • A61K38/42Haemoglobins; Myoglobins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02796353T 2001-08-24 2002-08-21 Amphotere lipidverbindung und deren verwendung ATE502005T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001254733A JP5093547B2 (ja) 2001-08-24 2001-08-24 両イオン性脂質およびその用途
PCT/JP2002/008419 WO2003018539A1 (en) 2001-08-24 2002-08-21 Amphoteric lipid compound and use thereof

Publications (1)

Publication Number Publication Date
ATE502005T1 true ATE502005T1 (de) 2011-04-15

Family

ID=19082849

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02796353T ATE502005T1 (de) 2001-08-24 2002-08-21 Amphotere lipidverbindung und deren verwendung

Country Status (7)

Country Link
US (1) US6965049B2 (de)
EP (1) EP1420010B1 (de)
JP (1) JP5093547B2 (de)
AT (1) ATE502005T1 (de)
CA (1) CA2458474C (de)
DE (1) DE60239468D1 (de)
WO (1) WO2003018539A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4712341B2 (ja) * 2003-10-20 2011-06-29 日油株式会社 リン脂質膜製剤
US20050266066A1 (en) * 2003-10-20 2005-12-01 Nof Corporation Phospholipid membrane preparation
JP2005154514A (ja) * 2003-11-21 2005-06-16 Univ Waseda 機能性生分解性材料およびその製造方法
US8647613B2 (en) 2005-03-16 2014-02-11 Jcr Pharmaceuticals Co., Ltd. Drug carrier
JP5038128B2 (ja) * 2005-03-16 2012-10-03 日本ケミカルリサーチ株式会社 薬物運搬体
WO2006118327A1 (ja) * 2005-04-27 2006-11-09 Oxygenix Co Ltd カチオン性アミノ酸型脂質
EP1906924B1 (de) * 2005-06-06 2018-05-02 Waseda University Auf das knochenmark gerichtete arzneimittel-abgabematerialien und ihre anwendungen
JP5253716B2 (ja) * 2006-02-09 2013-07-31 日本ケミカルリサーチ株式会社 pH応答性分子集合体
EP1935434A1 (de) * 2006-12-19 2008-06-25 Novosom AG Konstruktion und Verwendung von transfektionsverstärkenden Elementen
JP5241711B2 (ja) * 2007-05-17 2013-07-17 学校法人早稲田大学 両親媒性分子、それを含む分子集合体及びその用途
JP5588619B2 (ja) * 2009-03-11 2014-09-10 一丸ファルコス株式会社 pH応答性リポソーム
US8420118B2 (en) 2009-09-10 2013-04-16 The Board Of Regents Of The University Of Oklahoma Anionic lipids and lipid nano-structures and methods of producing and using same
FR2977585B1 (fr) * 2011-07-06 2015-08-28 Ard Sa Procede de preparation d'esters
KR102081046B1 (ko) * 2012-03-16 2020-02-25 메르크 파텐트 게엠베하 아미노산 지질
SG11201405552VA (en) * 2012-03-16 2014-10-30 Merck Patent Gmbh Targeting aminoacid lipids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3806852A1 (de) * 1988-03-03 1989-09-14 Knoll Ag Neue (alpha)-aminodicarbonsaeure-derivate, ihre herstellung und verwendung
JP4375868B2 (ja) * 2000-02-03 2009-12-02 セーレン株式会社 表面改質剤組成物および該組成物で処理された繊維
JP4226324B2 (ja) * 2000-11-10 2009-02-18 学校法人早稲田大学 カルボン酸型脂質

Also Published As

Publication number Publication date
WO2003018539A1 (en) 2003-03-06
EP1420010B1 (de) 2011-03-16
EP1420010A4 (de) 2009-06-24
CA2458474A1 (en) 2003-03-06
JP2003064037A (ja) 2003-03-05
US6965049B2 (en) 2005-11-15
DE60239468D1 (de) 2011-04-28
CA2458474C (en) 2009-09-29
US20040162261A1 (en) 2004-08-19
JP5093547B2 (ja) 2012-12-12
EP1420010A1 (de) 2004-05-19

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