EA199800768A1 - Новые производные эритромицина, способ их получения и их применение в качестве медикаментов - Google Patents

Новые производные эритромицина, способ их получения и их применение в качестве медикаментов

Info

Publication number
EA199800768A1
EA199800768A1 EA199800768A EA199800768A EA199800768A1 EA 199800768 A1 EA199800768 A1 EA 199800768A1 EA 199800768 A EA199800768 A EA 199800768A EA 199800768 A EA199800768 A EA 199800768A EA 199800768 A1 EA199800768 A1 EA 199800768A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
production
medical documents
erythromycin derivatives
new erythromycin
Prior art date
Application number
EA199800768A
Other languages
English (en)
Other versions
EA001376B1 (ru
Inventor
Константэн Агуридас
Жан-Франсуа Шанто
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA199800768A1 publication Critical patent/EA199800768A1/ru
Publication of EA001376B1 publication Critical patent/EA001376B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Изобретение относится к соединениям формулы (I), в которых:Х представляет собой радикал СНили SO, или атом кислорода, Y представляет собой радикал (CH)- (СН = СН)(СН), где m + n + о ≤ 8, n = 0 или 1, Ar представляет собой арил, W представляет собой атом водорода или остаток карбаматной функции. Соединения формулы (I) обладают интересными антибиотическими свойствами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800768A 1996-02-28 1997-02-27 Новые производные эритромицина, способ их получения и их применение в качестве медикаментов EA001376B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9602472A FR2745290B1 (fr) 1996-02-28 1996-02-28 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
PCT/FR1997/000351 WO1997031929A1 (fr) 1996-02-28 1997-02-27 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
EA199800768A1 true EA199800768A1 (ru) 1999-02-25
EA001376B1 EA001376B1 (ru) 2001-02-26

Family

ID=9489659

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800768A EA001376B1 (ru) 1996-02-28 1997-02-27 Новые производные эритромицина, способ их получения и их применение в качестве медикаментов

Country Status (31)

Country Link
US (1) US6096714A (ru)
EP (1) EP0885234B1 (ru)
JP (1) JP4102440B2 (ru)
KR (1) KR100486053B1 (ru)
CN (1) CN1168734C (ru)
AP (1) AP952A (ru)
AR (1) AR005999A1 (ru)
AT (1) ATE217633T1 (ru)
AU (1) AU716204B2 (ru)
BG (1) BG63207B1 (ru)
BR (1) BR9707709B1 (ru)
CZ (1) CZ293893B6 (ru)
DE (1) DE69712610T2 (ru)
DK (1) DK0885234T3 (ru)
EA (1) EA001376B1 (ru)
EE (1) EE9800265A (ru)
ES (1) ES2176698T3 (ru)
FR (1) FR2745290B1 (ru)
HU (1) HU227567B1 (ru)
IL (1) IL125622A (ru)
NO (1) NO983955L (ru)
NZ (1) NZ331600A (ru)
OA (1) OA10845A (ru)
PL (1) PL191736B1 (ru)
PT (1) PT885234E (ru)
SK (1) SK118498A3 (ru)
TR (1) TR199801713T2 (ru)
UA (1) UA58504C2 (ru)
WO (1) WO1997031929A1 (ru)
YU (1) YU37098A (ru)
ZA (1) ZA971659B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA989835B (en) * 1997-10-29 1999-05-05 Taisho Pharmaceutical Co Ltd Erythromycin a derivatives
WO1999021870A1 (en) * 1997-10-29 1999-05-06 Taisho Pharmaceutical Co., Ltd. Erythromycin a 11, 12-carbamate derivatives
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
OA11753A (en) 1999-01-27 2005-07-19 Pfizer Prod Inc Ketolide antibiotics.
OA11945A (en) * 1999-05-24 2006-04-13 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
WO2001010878A1 (fr) * 1999-08-06 2001-02-15 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
AU6316400A (en) * 1999-08-06 2001-03-05 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6183800A (en) * 1999-08-06 2001-03-05 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
EP1146051A3 (en) * 2000-04-10 2001-10-31 Pfizer Products Inc. Erythromycin A derivatives
US20020115621A1 (en) * 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
ITMI20021726A1 (it) 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
WO2005007143A2 (en) * 2003-07-14 2005-01-27 The Board Of Trustees Of The University Of Illinois Use of makrolides and ketolides for the treatment of tuberculosis
WO2007069264A2 (en) * 2005-12-15 2007-06-21 Alembic Limited Reference standards for determining the purity of telithromycin and processes therefor
CN105732745A (zh) * 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
AU2009308180B2 (en) 2008-10-24 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating gastrointestinal diseases
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
ES2564097T3 (es) 2010-03-22 2016-03-17 Cempra Pharmaceuticals, Inc. Formas cristalinas de un macrólido, y usos de las mismas
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
JP6208742B2 (ja) 2012-03-27 2017-10-04 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗生物質を投与するための非経口製剤
CN105163785A (zh) 2013-03-14 2015-12-16 森普拉制药公司 用于治疗呼吸道疾病的方法及其制剂
WO2014145210A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487411A (en) * 1892-12-06 Island
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5444031A (en) * 1993-01-21 1995-08-22 Calgon Carbon Corporation Process for making catalytic carbon
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
US6096714A (en) 2000-08-01
PL191736B1 (pl) 2006-06-30
EP0885234A1 (fr) 1998-12-23
AR005999A1 (es) 1999-07-21
AU716204B2 (en) 2000-02-24
YU37098A (sh) 1999-07-28
SK118498A3 (en) 1999-07-12
DE69712610D1 (de) 2002-06-20
AU1929897A (en) 1997-09-16
BG63207B1 (bg) 2001-06-29
DK0885234T3 (da) 2002-08-26
CZ258798A3 (cs) 1998-12-16
IL125622A (en) 2003-10-31
EP0885234B1 (fr) 2002-05-15
BR9707709A (pt) 1999-04-06
KR100486053B1 (ko) 2005-06-16
NO983955D0 (no) 1998-08-27
HUP9902576A3 (en) 2001-03-28
NO983955L (no) 1998-08-27
TR199801713T2 (xx) 1998-12-21
EA001376B1 (ru) 2001-02-26
CN1168734C (zh) 2004-09-29
UA58504C2 (ru) 2003-08-15
BG102691A (en) 1999-06-30
ES2176698T3 (es) 2002-12-01
AP952A (en) 2001-03-29
KR19990087324A (ko) 1999-12-27
FR2745290B1 (fr) 1998-04-03
CZ293893B6 (cs) 2004-08-18
PL328608A1 (en) 1999-02-01
ZA971659B (en) 1998-02-26
HU227567B1 (en) 2011-08-29
OA10845A (fr) 2003-02-05
PT885234E (pt) 2002-10-31
EE9800265A (et) 1999-02-15
BR9707709B1 (pt) 2014-10-14
AP9801318A0 (en) 1998-09-30
IL125622A0 (en) 1999-04-11
JP2000505469A (ja) 2000-05-09
HUP9902576A1 (hu) 1999-12-28
ATE217633T1 (de) 2002-06-15
WO1997031929A1 (fr) 1997-09-04
FR2745290A1 (fr) 1997-08-29
JP4102440B2 (ja) 2008-06-18
NZ331600A (en) 1999-08-30
CN1212700A (zh) 1999-03-31
DE69712610T2 (de) 2002-11-28

Similar Documents

Publication Publication Date Title
EA199800768A1 (ru) Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
BG100951A (en) Novel erythromycin derivatives, method for their preparation and their use as drugs
DE69301897D1 (de) Erythromycinderivate, ihr Verfahren zur Herstellung und ihre Verwendung als Arzneimitteln
NO970495D0 (no) Aryltioforbindelser som anti-bakterielle og antivirale midler
AU4523797A (en) Atherosclerosis treatment
ES2077070T3 (es) Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable.
DE69226815T2 (de) 1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika
EA199800109A1 (ru) Производные азетидинона для лечения атеросклероза
AT380471B (de) Verfahren zur herstellung von neuen 2-oxoazetidin-derivate
AU2321688A (en) Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloalkanes
EA199900156A1 (ru) Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
EA199900528A1 (ru) Новые производные эритромицина, способ их получения и применения в качетве медикаментов
DE69904940D1 (de) 6-deoxy-erythromycin-derivate, ihrer herstellung, und ihrer verwendung als arzneimitteln
EA199800767A1 (ru) Производные 1(2h)хинолинкарбоновой кислоты, способ их получения и их применение в синтезе веществ, обладающих антибиотическими свойствами

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MK4A Patent expired

Designated state(s): RU