DE69226815T2 - 1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika - Google Patents

1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika

Info

Publication number
DE69226815T2
DE69226815T2 DE69226815T DE69226815T DE69226815T2 DE 69226815 T2 DE69226815 T2 DE 69226815T2 DE 69226815 T DE69226815 T DE 69226815T DE 69226815 T DE69226815 T DE 69226815T DE 69226815 T2 DE69226815 T2 DE 69226815T2
Authority
DE
Germany
Prior art keywords
antibiotics
methyl
production
carbapenem derivatives
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69226815T
Other languages
English (en)
Other versions
DE69226815D1 (de
Inventor
Isao Kawamoto
Rokuro Endo
Masao Miyauchi
Katsuhiko Watanabe
Eiji Nakayama
Hiroshi Yasuda
Satoshi Ohya
Yukio Utsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of DE69226815D1 publication Critical patent/DE69226815D1/de
Application granted granted Critical
Publication of DE69226815T2 publication Critical patent/DE69226815T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
DE69226815T 1991-06-04 1992-06-04 1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika Expired - Fee Related DE69226815T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP13154591 1991-06-04
JP34573791 1991-12-27
JP3052192 1992-02-18
JP9128392 1992-04-10

Publications (2)

Publication Number Publication Date
DE69226815D1 DE69226815D1 (de) 1998-10-08
DE69226815T2 true DE69226815T2 (de) 1999-05-20

Family

ID=27459269

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226815T Expired - Fee Related DE69226815T2 (de) 1991-06-04 1992-06-04 1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika

Country Status (21)

Country Link
EP (1) EP0518558B1 (de)
JP (1) JP2559949B2 (de)
KR (1) KR100247855B1 (de)
CN (1) CN1030767C (de)
AT (1) ATE170521T1 (de)
AU (1) AU651887B2 (de)
CA (1) CA2070305A1 (de)
CZ (1) CZ167792A3 (de)
DE (1) DE69226815T2 (de)
DK (1) DK0518558T3 (de)
ES (1) ES2120992T3 (de)
FI (1) FI101226B1 (de)
HK (1) HK1011980A1 (de)
HU (2) HU218289B (de)
IE (1) IE921796A1 (de)
IL (1) IL102093A (de)
MX (1) MX9202670A (de)
NO (1) NO302475B1 (de)
NZ (1) NZ243022A (de)
RU (1) RU2093514C1 (de)
TW (1) TW203612B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CZ290002B6 (cs) * 1992-03-11 2002-05-15 Sankyo Company Limited Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek
GB9304156D0 (en) * 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
EP0581502B1 (de) * 1992-07-21 1998-10-21 Zeneca Limited Antibiotische carbapenemverbindungen
CA2099818A1 (en) * 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
JP3848693B2 (ja) * 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
NZ324447A (en) * 1995-12-21 1999-08-30 Sankyo Co 1-methyl-carbapenem substituted by a 4-pyrrolidinylthio group and medicaments
ATE222588T1 (de) * 1996-04-26 2002-09-15 Sankyo Co Ein 1-methylcarbapenem-derivat
JP2001500118A (ja) 1996-08-17 2001-01-09 ゼネカ・リミテッド ファルネシルタンパク質トランスフェラーゼ阻害剤としての３―メルカプトピロリジン
WO2000034282A1 (fr) * 1998-12-07 2000-06-15 Sankyo Company, Limited Derives de 1-methylcarbapenem
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
WO2003024928A2 (en) 2001-09-14 2003-03-27 Novo Nordisk A/S Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
CN101367814B (zh) * 2007-06-28 2010-12-15 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰哌啶取代的培南衍生物
US8236792B2 (en) * 2008-05-23 2012-08-07 Janssen Pharmaceutica Nv Substituted pyrrolidine amides as modulators of the histamine H3 receptor
WO2017158616A1 (en) 2016-03-16 2017-09-21 Orchid Pharma Ltd. Carbapenem compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60233076A (ja) * 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
DE3780344T2 (de) * 1986-03-27 1993-01-28 Sumitomo Pharma Beta-lactam-verbindungen und deren herstellung.
CA2036163C (en) * 1990-02-14 2001-06-19 Makoto Sunagawa Novel beta-lactam compounds and their production
FI96863C (fi) * 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
TW198034B (de) * 1990-03-27 1993-01-11 Manyu Seiyaku Kk
AU644008B2 (en) * 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
CZ290002B6 (cs) * 1992-03-11 2002-05-15 Sankyo Company Limited Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek

Also Published As

Publication number Publication date
EP0518558A1 (de) 1992-12-16
DE69226815D1 (de) 1998-10-08
JP2559949B2 (ja) 1996-12-04
IL102093A (en) 1996-12-05
FI101226B (fi) 1998-05-15
AU1739092A (en) 1993-03-11
NO922185L (no) 1992-12-07
HK1011980A1 (en) 1999-07-23
FI922561A (fi) 1992-12-05
NZ243022A (en) 1993-07-27
HU9201871D0 (en) 1992-08-28
EP0518558B1 (de) 1998-09-02
HUT61551A (en) 1993-01-28
NO922185D0 (no) 1992-06-03
HU211822A9 (en) 1995-12-28
HU218289B (en) 2000-07-28
TW203612B (de) 1993-04-11
AU651887B2 (en) 1994-08-04
FI101226B1 (fi) 1998-05-15
DK0518558T3 (da) 1999-05-31
KR100247855B1 (ko) 2000-05-01
ES2120992T3 (es) 1998-11-16
IE921796A1 (en) 1992-12-16
FI922561A0 (fi) 1992-06-03
NO302475B1 (no) 1998-03-09
CN1030767C (zh) 1996-01-24
CZ167792A3 (en) 1995-12-13
CN1069494A (zh) 1993-03-03
MX9202670A (es) 1993-01-01
RU2093514C1 (ru) 1997-10-20
ATE170521T1 (de) 1998-09-15
CA2070305A1 (en) 1992-12-05
JPH05339269A (ja) 1993-12-21
IL102093A0 (en) 1993-01-14
KR930000515A (ko) 1993-01-15

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee