EE03071B1 - Karbasolooni derivaadid ja nende saamise protsess - Google Patents

Karbasolooni derivaadid ja nende saamise protsess

Info

Publication number
EE03071B1
EE03071B1 EE9400092A EE9400092A EE03071B1 EE 03071 B1 EE03071 B1 EE 03071B1 EE 9400092 A EE9400092 A EE 9400092A EE 9400092 A EE9400092 A EE 9400092A EE 03071 B1 EE03071 B1 EE 03071B1
Authority
EE
Estonia
Prior art keywords
formula
methyl
group
chem
production process
Prior art date
Application number
EE9400092A
Other languages
English (en)
Inventor
Bod P�ter
Hars�nyi K�lm�n
Trischler Ferenc
Fekecs Va
Csehi Attila
Heged�s B�la
Mersich n�e Don�t �va
Szab� n�e Koml�si Gy�rgyi
Horv�th n�e Sziki Erika
Original Assignee
Richter Gedeon Vegy�Szeti Gy�R Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26318102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03071(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from HU9203223A external-priority patent/HU212785B/hu
Priority claimed from HU9203222A external-priority patent/HU212934B/hu
Application filed by Richter Gedeon Vegy�Szeti Gy�R Rt. filed Critical Richter Gedeon Vegy�Szeti Gy�R Rt.
Publication of EE03071B1 publication Critical patent/EE03071B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
EE9400092A 1992-10-14 1994-07-19 Karbasolooni derivaadid ja nende saamise protsess EE03071B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9203223A HU212785B (en) 1992-10-14 1992-10-14 Process for producing of a carbazolone derivative
HU9203222A HU212934B (en) 1992-10-14 1992-10-14 Process for producing novel alkoxalylated carbazolone derivatives

Publications (1)

Publication Number Publication Date
EE03071B1 true EE03071B1 (et) 1998-02-16

Family

ID=26318102

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400092A EE03071B1 (et) 1992-10-14 1994-07-19 Karbasolooni derivaadid ja nende saamise protsess

Country Status (20)

Country Link
US (2) US5416221A (et)
EP (1) EP0595111B2 (et)
JP (1) JP3378315B2 (et)
KR (1) KR100289912B1 (et)
CN (2) CN1052979C (et)
AT (1) ATE157973T1 (et)
CA (1) CA2106642C (et)
CZ (1) CZ284223B6 (et)
DE (1) DE69313771T3 (et)
DK (1) DK0595111T4 (et)
EE (1) EE03071B1 (et)
ES (1) ES2106936T5 (et)
GR (1) GR3025599T3 (et)
HR (1) HRP931292B1 (et)
PL (2) PL174526B1 (et)
RO (1) RO115799B1 (et)
RU (1) RU2119914C1 (et)
SI (1) SI9300537B (et)
SK (1) SK281243B6 (et)
UA (2) UA26893C2 (et)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226135B1 (en) * 2000-03-28 2008-05-28 Richter Gedeon Nyrt Intermediate of ondansetron and process for its production
KR100368895B1 (ko) * 2000-03-30 2003-01-24 하나제약 주식회사 1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법
SK6182003A3 (en) * 2000-10-30 2004-03-02 Teva Pharma Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
DE60314400T2 (de) * 2002-04-29 2008-02-07 Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag Verfahren zur herstellung von 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-on
US20050131045A1 (en) * 2002-04-30 2005-06-16 Judith Aronhime Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them
JP2005529908A (ja) * 2002-04-30 2005-10-06 テバ ジョジセルジャール レースベニュタールシャシャーグ オンダンセトロンの新規結晶形、その製法、当該新規形を含有する医薬組成物、及び当該組成物を用いる吐気の治療方法
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
GEP20094682B (en) * 2004-07-12 2009-05-10 Cadila Healthcare Ltd Tricyclic pyrazole derivatives as cannabinoid receptor modulators
US7696356B2 (en) * 2004-08-17 2010-04-13 Taro Pharmaceutical Industries Limited Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom
EP1828141A4 (en) * 2004-10-26 2009-04-01 Ipca Lab Ltd STAINING METHOD FOR PREPARING THE ANTIEMETIC 1,2,3,9-TETRAHYDRO-9-METHYL-3 - [(2-METHYL) -1H-IMIDAZOLE-1-YL) METHYL] -4H-CARBAZOLE-4-ON
CN115677561B (zh) * 2022-11-01 2024-04-05 常州兰陵制药有限公司 一种1,2,3,4-四氢-9-甲基-4h-咔唑酮及其合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
CH664152A5 (fr) * 1984-01-25 1988-02-15 Glaxo Group Ltd Derives de tetrahydrocarbazolones.
CN1011237B (zh) * 1984-01-25 1991-01-16 格拉克索公司 1，2，3，9-四氢-3-[(2-甲基-1h-咪唑-1-基)甲基]-4h-咔唑-4-酮类和其盐以及溶剂化物的制备
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
GB8628473D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Chemical compounds
JPH01258673A (ja) * 1987-10-22 1989-10-16 Glaxo Group Ltd ケトン誘導体

Also Published As

Publication number Publication date
ES2106936T3 (es) 1997-11-16
JP3378315B2 (ja) 2003-02-17
ATE157973T1 (de) 1997-09-15
RU2119914C1 (ru) 1998-10-10
DK0595111T3 (da) 1998-04-14
UA26893C2 (uk) 1999-12-29
DE69313771D1 (de) 1997-10-16
CN1083430C (zh) 2002-04-24
ES2106936T5 (es) 2001-12-16
KR100289912B1 (ko) 2001-09-17
DE69313771T2 (de) 1998-02-12
DK0595111T4 (da) 2001-10-22
CN1052979C (zh) 2000-05-31
PL174526B1 (pl) 1998-08-31
CA2106642A1 (en) 1994-04-15
CA2106642C (en) 2005-08-16
CN1235967A (zh) 1999-11-24
PL300685A1 (en) 1994-04-18
US5416221A (en) 1995-05-16
CZ284223B6 (cs) 1998-09-16
KR940009152A (ko) 1994-05-20
JPH06293734A (ja) 1994-10-21
SK281243B6 (sk) 2001-01-18
US5478949A (en) 1995-12-26
CN1089941A (zh) 1994-07-27
HRP931292A2 (en) 1994-12-31
EP0595111B2 (en) 2001-08-16
SK111093A3 (en) 1994-11-09
CZ215693A3 (en) 1994-05-18
SI9300537A (en) 1994-06-30
HRP931292B1 (en) 1999-08-31
EP0595111B1 (en) 1997-09-10
SI9300537B (sl) 2003-02-28
DE69313771T3 (de) 2002-04-18
RO115799B1 (ro) 2000-06-30
EP0595111A1 (en) 1994-05-04
UA27022C2 (uk) 2000-02-28
GR3025599T3 (en) 1998-03-31
PL174173B1 (pl) 1998-06-30

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Effective date: 20090719