UA27022C2 - Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhу - Google Patents
Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhуInfo
- Publication number
- UA27022C2 UA27022C2 UA99052847A UA99052847A UA27022C2 UA 27022 C2 UA27022 C2 UA 27022C2 UA 99052847 A UA99052847 A UA 99052847A UA 99052847 A UA99052847 A UA 99052847A UA 27022 C2 UA27022 C2 UA 27022C2
- Authority
- UA
- Ukraine
- Prior art keywords
- carbasolon
- intermediates
- synthesis
- derivatives
- ondansetron
- Prior art date
Links
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 229960005343 ondansetron Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Photoreceptors In Electrophotography (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Винахід належить до галузі медицини, зокрема до лікарських препаратів. В основу винаходу поставлено завдання створення похідних карбазолону як проміжних продуктів для отримання чистого ондансетрону з 100%-ним виходом.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9203223A HU212785B (en) | 1992-10-14 | 1992-10-14 | Process for producing of a carbazolone derivative |
HU9203222A HU212934B (en) | 1992-10-14 | 1992-10-14 | Process for producing novel alkoxalylated carbazolone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
UA27022C2 true UA27022C2 (uk) | 2000-02-28 |
Family
ID=26318102
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA93002172A UA26893C2 (uk) | 1992-10-14 | 1993-10-11 | Спосіб отримаhhя оhдасетроhу та його фармацевтичhо прийhятhих солей |
UA99052847A UA27022C2 (uk) | 1992-10-14 | 1999-05-24 | Похідhі карбазолоhу як проміжhі сполуки для отримаhhя оhдаhсетроhу |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA93002172A UA26893C2 (uk) | 1992-10-14 | 1993-10-11 | Спосіб отримаhhя оhдасетроhу та його фармацевтичhо прийhятhих солей |
Country Status (20)
Country | Link |
---|---|
US (2) | US5416221A (uk) |
EP (1) | EP0595111B2 (uk) |
JP (1) | JP3378315B2 (uk) |
KR (1) | KR100289912B1 (uk) |
CN (2) | CN1052979C (uk) |
AT (1) | ATE157973T1 (uk) |
CA (1) | CA2106642C (uk) |
CZ (1) | CZ284223B6 (uk) |
DE (1) | DE69313771T3 (uk) |
DK (1) | DK0595111T4 (uk) |
EE (1) | EE03071B1 (uk) |
ES (1) | ES2106936T5 (uk) |
GR (1) | GR3025599T3 (uk) |
HR (1) | HRP931292B1 (uk) |
PL (2) | PL174526B1 (uk) |
RO (1) | RO115799B1 (uk) |
RU (1) | RU2119914C1 (uk) |
SI (1) | SI9300537B (uk) |
SK (1) | SK281243B6 (uk) |
UA (2) | UA26893C2 (uk) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU226135B1 (en) * | 2000-03-28 | 2008-05-28 | Richter Gedeon Nyrt | Intermediate of ondansetron and process for its production |
KR100368895B1 (ko) * | 2000-03-30 | 2003-01-24 | 하나제약 주식회사 | 1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1h-이미다졸-1-일)메틸]-4h-카바졸-4-온의 제조방법 |
DE01991193T1 (de) * | 2000-10-30 | 2004-07-08 | Teva Pharmaceutical Industries Ltd. | Neue kristall- und solvatformen von ondansetronhydrochlorid und verfahren zu deren herstellung |
EP1207160A1 (en) * | 2000-11-20 | 2002-05-22 | Hanmi Pharm. Co., Ltd. | Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one |
PT1499623E (pt) * | 2002-04-29 | 2007-08-10 | Teva Gyogyszergyar Zartkoeruee | ''processo papa a preparação de 1, 2, 3, 9-tetra-hidro-9-metil-3- [(2-metil-1h-imidazol-1-il) metil] -4h-carbazol-4-ona'' |
CN1665803A (zh) * | 2002-04-30 | 2005-09-07 | 特瓦药厂有限公司 | 新晶形的昂丹司琼及其制备方法、含有该新晶形的药物组合物以及用其治疗恶心的方法 |
US20050131045A1 (en) * | 2002-04-30 | 2005-06-16 | Judith Aronhime | Novel crystal forms of ondansetron, processes for their preparation, pharmaceutical, compositions containing the novel forms and methods for treating nausea using them |
FI6164U1 (fi) * | 2003-01-09 | 2004-03-15 | Synthon Bv | Ondansetronmuotoja |
US7390503B1 (en) | 2003-08-22 | 2008-06-24 | Barr Laboratories, Inc. | Ondansetron orally disintegrating tablets |
AU2005278781B2 (en) * | 2004-07-12 | 2009-06-18 | Cadila Healthcare Limited | Tricyclic pyrazole derivatives as cannabinoid receptor modulators |
US7696356B2 (en) * | 2004-08-17 | 2010-04-13 | Taro Pharmaceutical Industries Limited | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom |
EP1828141A4 (en) * | 2004-10-26 | 2009-04-01 | Ipca Lab Ltd | STAINING METHOD FOR PREPARING THE ANTIEMETIC 1,2,3,9-TETRAHYDRO-9-METHYL-3 - [(2-METHYL) -1H-IMIDAZOLE-1-YL) METHYL] -4H-CARBAZOLE-4-ON |
CN115677561B (zh) * | 2022-11-01 | 2024-04-05 | 常州兰陵制药有限公司 | 一种1,2,3,4-四氢-9-甲基-4h-咔唑酮及其合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3579534A (en) * | 1969-05-09 | 1971-05-18 | American Cyanamid Co | Tetrahydrocarbazolecarboxylates |
CN1011237B (zh) * | 1984-01-25 | 1991-01-16 | 格拉克索公司 | 1,2,3,9-四氢-3-[(2-甲基-1h-咪唑-1-基)甲基]-4h-咔唑-4-酮类和其盐以及溶剂化物的制备 |
HU193592B (en) * | 1984-01-25 | 1987-11-30 | Glaxo Group Ltd | Process for producing tetrahydro-carbazolone derivatives |
GB8518742D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
GB8617994D0 (en) * | 1986-07-23 | 1986-08-28 | Glaxo Group Ltd | Heterocyclic compounds |
GB8628473D0 (en) * | 1986-11-28 | 1987-01-07 | Glaxo Group Ltd | Chemical compounds |
JPH01258673A (ja) * | 1987-10-22 | 1989-10-16 | Glaxo Group Ltd | ケトン誘導体 |
-
1993
- 1993-09-21 CA CA002106642A patent/CA2106642C/en not_active Expired - Fee Related
- 1993-10-08 HR HR3223/92A patent/HRP931292B1/xx not_active IP Right Cessation
- 1993-10-11 UA UA93002172A patent/UA26893C2/uk unknown
- 1993-10-13 SK SK1110-93A patent/SK281243B6/sk unknown
- 1993-10-13 KR KR1019930021223A patent/KR100289912B1/ko not_active IP Right Cessation
- 1993-10-13 AT AT93116542T patent/ATE157973T1/de not_active IP Right Cessation
- 1993-10-13 DE DE69313771T patent/DE69313771T3/de not_active Expired - Fee Related
- 1993-10-13 JP JP25588093A patent/JP3378315B2/ja not_active Expired - Fee Related
- 1993-10-13 SI SI9300537A patent/SI9300537B/sl not_active IP Right Cessation
- 1993-10-13 ES ES93116542T patent/ES2106936T5/es not_active Expired - Lifetime
- 1993-10-13 DK DK93116542T patent/DK0595111T4/da active
- 1993-10-13 CZ CZ932156A patent/CZ284223B6/cs not_active IP Right Cessation
- 1993-10-13 CN CN93119192A patent/CN1052979C/zh not_active Expired - Fee Related
- 1993-10-13 RU RU93049416A patent/RU2119914C1/ru not_active IP Right Cessation
- 1993-10-13 RO RO93-01370A patent/RO115799B1/ro unknown
- 1993-10-13 US US08/135,407 patent/US5416221A/en not_active Expired - Lifetime
- 1993-10-13 EP EP93116542A patent/EP0595111B2/en not_active Expired - Lifetime
- 1993-10-13 PL PL93324329A patent/PL174526B1/pl not_active IP Right Cessation
- 1993-10-13 PL PL93300685A patent/PL174173B1/pl not_active IP Right Cessation
-
1994
- 1994-07-19 EE EE9400092A patent/EE03071B1/xx not_active IP Right Cessation
- 1994-11-25 US US08/344,871 patent/US5478949A/en not_active Expired - Lifetime
-
1997
- 1997-12-04 GR GR970403244T patent/GR3025599T3/el unknown
-
1999
- 1999-05-11 CN CN99106445A patent/CN1083430C/zh not_active Expired - Fee Related
- 1999-05-24 UA UA99052847A patent/UA27022C2/uk unknown
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