DK0835258T3 - Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse - Google Patents

Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse

Info

Publication number
DK0835258T3
DK0835258T3 DK96924010T DK96924010T DK0835258T3 DK 0835258 T3 DK0835258 T3 DK 0835258T3 DK 96924010 T DK96924010 T DK 96924010T DK 96924010 T DK96924010 T DK 96924010T DK 0835258 T3 DK0835258 T3 DK 0835258T3
Authority
DK
Denmark
Prior art keywords
medicines
preparation
hydroxy
methods
lower alkyl
Prior art date
Application number
DK96924010T
Other languages
English (en)
Inventor
Gerard Ulibarri
Dennis Bigg
Jacques Pommier
Olivier Lavergne
Rodas Francesc Pla
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9512670.2A external-priority patent/GB9512670D0/en
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of DK0835258T3 publication Critical patent/DK0835258T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK96924010T 1995-06-21 1996-06-21 Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse DK0835258T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9512670.2A GB9512670D0 (en) 1995-06-21 1995-06-21 Camptothecin analogues
US61047696A 1996-03-04 1996-03-04
PCT/FR1996/000980 WO1997000876A1 (fr) 1995-06-21 1996-06-21 Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
DK0835258T3 true DK0835258T3 (da) 2003-02-03

Family

ID=26307258

Family Applications (2)

Application Number Title Priority Date Filing Date
DK96924010T DK0835258T3 (da) 1995-06-21 1996-06-21 Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse
DK02077736T DK1251125T3 (da) 1995-06-21 1996-06-21 Hidtil ukendte camptothecin-analoger, fremgangsmåde til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK02077736T DK1251125T3 (da) 1995-06-21 1996-06-21 Hidtil ukendte camptothecin-analoger, fremgangsmåde til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse

Country Status (24)

Country Link
EP (2) EP0835258B1 (da)
JP (2) JP3576171B2 (da)
KR (1) KR100440838B1 (da)
CN (1) CN1114608C (da)
AT (2) ATE224900T1 (da)
AU (1) AU716377B2 (da)
BR (1) BR9608639A (da)
CA (1) CA2225528C (da)
CL (1) CL2004001168A1 (da)
CZ (1) CZ296156B6 (da)
DE (2) DE69635560T2 (da)
DK (2) DK0835258T3 (da)
ES (2) ES2254600T3 (da)
HK (3) HK1015783A1 (da)
IL (2) IL122635A (da)
MX (1) MX9710228A (da)
NO (1) NO316749B1 (da)
NZ (1) NZ312715A (da)
PL (1) PL185354B1 (da)
PT (1) PT835258E (da)
RO (1) RO117918B1 (da)
RU (1) RU2164515C2 (da)
TW (1) TW457234B (da)
WO (1) WO1997000876A1 (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
FR2757514B1 (fr) * 1996-12-20 1999-02-12 Sod Conseils Rech Applic Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2768431B1 (fr) * 1997-08-29 2000-03-24 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation
FR2757515B1 (fr) * 1996-12-20 2000-05-05 Sod Conseils Rech Applic Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
US6559309B2 (en) * 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
UA57757C2 (uk) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
FR2772763B1 (fr) * 1997-12-24 2004-01-23 Sod Conseils Rech Applic Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
DE19826499A1 (de) * 1998-06-13 1999-12-16 Beiersdorf Ag Gegen Bakterien, Mycota, Viren, Parasiten und Protozoen wirksame Substanzen
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6667313B1 (en) 1999-08-27 2003-12-23 Ligand Pharmaceuticals Inc. 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
AU778655B2 (en) 1999-08-27 2004-12-16 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
PE20010647A1 (es) 1999-09-14 2001-06-23 Lilly Co Eli Moduladores de receptores de retinoide x (rxr) con perfil farmacologico mejorado
FR2801309B1 (fr) * 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2273841T3 (es) 2000-02-28 2007-05-16 Pfizer Enterprises Sarl Combinacion sinergica para el tratamiento de cancer colorrectal.
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
PL365685A1 (en) 2000-10-27 2005-01-10 Aventis Pharma S.A. A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
FR2825278A1 (fr) * 2001-05-30 2002-12-06 Sod Conseils Rech Applic Produit comprenant du mikanolide, du dihydromikanolide ou un analogue de ceux-ci en association avec un autre agent anti-cancereux pour une utilisation therapeutique dans le traitement du cancer
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
US20040077674A1 (en) * 2002-03-01 2004-04-22 Curran Dennis P. Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
ITRM20020305A1 (it) 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
CN100408582C (zh) * 2004-02-12 2008-08-06 中国人民解放军第二军医大学 高喜树碱类化合物及其制备方法和用途
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
WO2006069344A2 (en) 2004-12-22 2006-06-29 Rutgers, The State University Of New Jersey Controlled release hydrogels
CN100339377C (zh) * 2005-09-05 2007-09-26 合肥中科大生物技术有限公司 喜树碱衍生物及其制备
CN1319971C (zh) * 2005-09-09 2007-06-06 合肥中科大生物技术有限公司 喜树碱衍生物及其用途
CN100465175C (zh) * 2005-11-29 2009-03-04 中国人民解放军第二军医大学 7-位取代高喜树碱类化合物及作为药物的用途
CN1319970C (zh) * 2005-12-30 2007-06-06 合肥中科大生物技术有限公司 一种用作抗肿瘤剂的喜树碱衍生物及其制备方法
US8410045B2 (en) 2006-03-30 2013-04-02 Drais Pharmaceuticals, Inc. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
MX2008013105A (es) * 2006-04-19 2008-10-27 Bionumerik Pharmaceuticals Inc Analogo de camptotecina con anillo e "basculante", estable en lactona, novedoso, y metodo para su fabricacion y uso.
CN101220037B (zh) * 2008-01-31 2011-02-16 中国人民解放军第二军医大学 10-位取代高喜树碱类化合物及其用途
CN100592871C (zh) * 2008-03-14 2010-03-03 浙江林学院 一种杀虫剂组合物及其加工方法
CN101979392A (zh) * 2010-09-26 2011-02-23 中国人民解放军第二军医大学 7-芳乙烯基取代高喜树碱类化合物及其作为药物的用途
US20140086975A1 (en) 2010-10-15 2014-03-27 Rutgers, The State University Of New Jersey Hydrogel formulation for dermal and ocular delivery
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN105601641B (zh) * 2015-12-22 2018-01-16 兰州大学 7‑位哌嗪磺酰胺喜树碱类化合物、制备方法及用途
CN106478648B (zh) * 2016-09-21 2018-11-06 桑迪亚医药技术（上海）有限责任公司 一种高喜树碱化合物及其合成方法
CN111777608B (zh) * 2020-07-08 2021-08-03 湖北精瑜材料有限公司 一种新型植物改性喹啉季铵盐化合物和制备方法及应用
WO2023232145A1 (zh) * 2022-06-02 2023-12-07 华东师范大学 一种高喜树碱类小分子及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs

Also Published As

Publication number Publication date
ES2254600T3 (es) 2006-06-16
DE69635560D1 (de) 2006-01-12
MX9710228A (es) 1998-03-31
NO975988D0 (no) 1997-12-19
RO117918B1 (ro) 2002-09-30
EP0835258B1 (fr) 2002-09-25
DE69623961T2 (de) 2003-05-08
ATE312105T1 (de) 2005-12-15
BR9608639A (pt) 1999-06-29
EP1251125B1 (fr) 2005-12-07
PL185354B1 (pl) 2003-04-30
NO975988L (no) 1998-02-19
JP2004123756A (ja) 2004-04-22
DE69623961D1 (de) 2002-10-31
AU716377B2 (en) 2000-02-24
IL122635A0 (en) 1998-08-16
CZ415397A3 (cs) 1998-08-12
RU2164515C2 (ru) 2001-03-27
EP1251125A2 (fr) 2002-10-23
JP3576171B2 (ja) 2004-10-13
WO1997000876A1 (fr) 1997-01-09
JPH11508249A (ja) 1999-07-21
DE69635560T2 (de) 2006-08-17
KR19990028263A (ko) 1999-04-15
CA2225528C (fr) 2007-06-05
PL324339A1 (en) 1998-05-25
HK1015783A1 (en) 1999-10-22
DK1251125T3 (da) 2006-04-18
NZ312715A (en) 2000-01-28
HK1056726A1 (en) 2004-02-27
NO316749B1 (no) 2004-04-26
KR100440838B1 (ko) 2004-12-17
CL2004001168A1 (es) 2005-05-20
PT835258E (pt) 2003-02-28
ES2184882T3 (es) 2003-04-16
TW457234B (en) 2001-10-01
ATE224900T1 (de) 2002-10-15
IL128044A0 (en) 1999-11-30
IL122635A (en) 2001-10-31
EP0835258A1 (fr) 1998-04-15
HK1050686A1 (en) 2003-07-04
CN1192740A (zh) 1998-09-09
AU6460896A (en) 1997-01-22
CA2225528A1 (fr) 1997-01-09
EP1251125A3 (fr) 2002-12-11
CZ296156B6 (cs) 2006-01-11
CN1114608C (zh) 2003-07-16

Similar Documents

Publication Publication Date Title
DK0835258T3 (da) Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse
NO2022019I1 (no) Eribulin eller et farmasøytisk akseptabelt salt derav - forlenget SPC
DK8885A (da) N-heterocyclyl-4-piperidinaminderivater og fremgangsmaade til fremstilling deraf
FI884626A0 (fi) Menetelmä terapeuttisesti käyttökelpoisen 4H-1-bentsopyran-4-onijohdoksen tai sen suolan valmistamiseksi ja menetelmässä käyttökelpoinen välituote
WO1987006226A3 (en) Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparations containing the absorption promoters
DE69621469T2 (de) Phenylpiperidin-derivate
PT91364A (pt) Processo para a preparacao de derivados de 3-piperazinil-benzazol e de composicoes farmaceuticas que os contem
DK0461986T3 (da) Hexahydroazepinderivater, en fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende disse
ES2060029T3 (es) Derivados de acido 6-fluorosiquimico.
FI960725A (fi) 4"-deoksi-4"-epi-metyyliaminoavermektiini Bla/Blb bentsoehapposuolan termodynaamiseksi stabiili kidemuoto ja menetelmät sen valmistamiseksi
ES2162126T3 (es) Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen.
ES2130392T3 (es) Procedimiento para la preparacion de acido clavulanico.
FI934303A0 (fi) Acylsulfonamido- och sulfonamidopyridin-2-karboxylsyraestrar och deraspyridin-n-oxider, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
ES2124757T3 (es) Composicion callicida que contiene naoh.
NO943008L (no) Renseblanding for galleveiene
BR8804486A (pt) Tinoalcanodifosfonatos de o-alquil-o-(6-metil-2-alquil-pirimidino-4-ilo),processo para sua preparacao,composicoes inseticidas,processo para o combate a atropodes e para a preparacao de artropodicidas
DE69026098D1 (de) Organogermaniumderivate enthaltende Zubereitungen zur therapeutischen Verwendung