NO975988L - Nye camptothecin-analoger, fremstillingsmetoder for disse, anvendelse derav som legemidler og farmasöytiske blandinger inneholdende nevnte analoger - Google Patents

Nye camptothecin-analoger, fremstillingsmetoder for disse, anvendelse derav som legemidler og farmasöytiske blandinger inneholdende nevnte analoger

Info

Publication number
NO975988L
NO975988L NO975988A NO975988A NO975988L NO 975988 L NO975988 L NO 975988L NO 975988 A NO975988 A NO 975988A NO 975988 A NO975988 A NO 975988A NO 975988 L NO975988 L NO 975988L
Authority
NO
Norway
Prior art keywords
analogs
pharmaceuticals
pharmaceutical compositions
hydroxy
compositions containing
Prior art date
Application number
NO975988A
Other languages
English (en)
Other versions
NO316749B1 (no
NO975988D0 (no
Inventor
Dennis Bigg
Olivier Lavergne
Francesc Pla Rodas
Jacques Pommier
Gerard Ulibarri
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9512670.2A external-priority patent/GB9512670D0/en
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of NO975988D0 publication Critical patent/NO975988D0/no
Publication of NO975988L publication Critical patent/NO975988L/no
Publication of NO316749B1 publication Critical patent/NO316749B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
NO19975988A 1995-06-21 1997-12-19 Nye camptothecin-analoger, fremstillingsmetoder for disse, anvendelse derav som legemidler og farmasoytiske blandinger inneholdende nevnte analoger NO316749B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9512670.2A GB9512670D0 (en) 1995-06-21 1995-06-21 Camptothecin analogues
US61047696A 1996-03-04 1996-03-04
PCT/FR1996/000980 WO1997000876A1 (fr) 1995-06-21 1996-06-21 Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (3)

Publication Number Publication Date
NO975988D0 NO975988D0 (no) 1997-12-19
NO975988L true NO975988L (no) 1998-02-19
NO316749B1 NO316749B1 (no) 2004-04-26

Family

ID=26307258

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19975988A NO316749B1 (no) 1995-06-21 1997-12-19 Nye camptothecin-analoger, fremstillingsmetoder for disse, anvendelse derav som legemidler og farmasoytiske blandinger inneholdende nevnte analoger

Country Status (24)

Country Link
EP (2) EP1251125B1 (no)
JP (2) JP3576171B2 (no)
KR (1) KR100440838B1 (no)
CN (1) CN1114608C (no)
AT (2) ATE312105T1 (no)
AU (1) AU716377B2 (no)
BR (1) BR9608639A (no)
CA (1) CA2225528C (no)
CL (1) CL2004001168A1 (no)
CZ (1) CZ296156B6 (no)
DE (2) DE69635560T2 (no)
DK (2) DK0835258T3 (no)
ES (2) ES2254600T3 (no)
HK (3) HK1015783A1 (no)
IL (2) IL122635A (no)
MX (1) MX9710228A (no)
NO (1) NO316749B1 (no)
NZ (1) NZ312715A (no)
PL (1) PL185354B1 (no)
PT (1) PT835258E (no)
RO (1) RO117918B1 (no)
RU (1) RU2164515C2 (no)
TW (1) TW457234B (no)
WO (1) WO1997000876A1 (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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FR2757514B1 (fr) * 1996-12-20 1999-02-12 Sod Conseils Rech Applic Nouveaux analogues de la camptothecine, des procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
FR2768431B1 (fr) * 1997-08-29 2000-03-24 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation
FR2757515B1 (fr) * 1996-12-20 2000-05-05 Sod Conseils Rech Applic Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
US6559309B2 (en) * 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
UA57757C2 (uk) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
FR2772763B1 (fr) * 1997-12-24 2004-01-23 Sod Conseils Rech Applic Nouveaux analogues tetracycliques de camptothecines, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
DE19826499A1 (de) * 1998-06-13 1999-12-16 Beiersdorf Ag Gegen Bakterien, Mycota, Viren, Parasiten und Protozoen wirksame Substanzen
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
JP2003508402A (ja) 1999-08-27 2003-03-04 リガンド・ファーマシューティカルズ・インコーポレイテッド アンドロゲン受容体モジュレーター化合物および方法
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
EP1212322A2 (en) 1999-08-27 2002-06-12 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators
CO5200852A1 (es) 1999-09-14 2002-09-27 Lilly Co Eli Moduladores rxr con mejorado perfil farmacologico ceptores x de los retinoides
FR2801309B1 (fr) * 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CZ298259B6 (cs) 2000-02-28 2007-08-08 Aventis Pharma S. A. Farmaceutická kombinace k lécení rakoviny obsahující CPT-11 a capecitabin
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
AU2002216029B2 (en) 2000-10-27 2006-01-05 Pfizer, Inc. A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
FR2825278A1 (fr) * 2001-05-30 2002-12-06 Sod Conseils Rech Applic Produit comprenant du mikanolide, du dihydromikanolide ou un analogue de ceux-ci en association avec un autre agent anti-cancereux pour une utilisation therapeutique dans le traitement du cancer
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
US20040077674A1 (en) * 2002-03-01 2004-04-22 Curran Dennis P. Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
ITRM20020305A1 (it) * 2002-05-31 2003-12-01 Sigma Tau Ind Farmaceuti Camptotecine con anello lattonico modificato.
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
CN100408582C (zh) * 2004-02-12 2008-08-06 中国人民解放军第二军医大学 高喜树碱类化合物及其制备方法和用途
ITRM20040288A1 (it) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti Uso della 7-t-butossiimminometilcamptotecina per la preparazione di un medicamento per il trattamento delle neoplasie dell'utero.
US20090104254A1 (en) 2004-12-22 2009-04-23 Rutgers, The State University Of New Jersey Controlled Release Hydrogels
CN100339377C (zh) * 2005-09-05 2007-09-26 合肥中科大生物技术有限公司 喜树碱衍生物及其制备
CN1319971C (zh) * 2005-09-09 2007-06-06 合肥中科大生物技术有限公司 喜树碱衍生物及其用途
CN100465175C (zh) * 2005-11-29 2009-03-04 中国人民解放军第二军医大学 7-位取代高喜树碱类化合物及作为药物的用途
CN1319970C (zh) * 2005-12-30 2007-06-06 合肥中科大生物技术有限公司 一种用作抗肿瘤剂的喜树碱衍生物及其制备方法
JP5313867B2 (ja) 2006-03-30 2013-10-09 ドライス ファーマシューティカルズ，インコーポレイティド カンプトテシン−細胞透過性ペプチド複合体及びそれを含む医薬組成物
EP2007386B1 (en) * 2006-04-19 2012-08-22 Bionumerik Pharmaceuticals, Inc. Camptothecin-analog with a novel, flipped lactone-stable, e-ring and methods for making and using same
CN101220037B (zh) * 2008-01-31 2011-02-16 中国人民解放军第二军医大学 10-位取代高喜树碱类化合物及其用途
CN100592871C (zh) * 2008-03-14 2010-03-03 浙江林学院 一种杀虫剂组合物及其加工方法
CN101979392A (zh) * 2010-09-26 2011-02-23 中国人民解放军第二军医大学 7-芳乙烯基取代高喜树碱类化合物及其作为药物的用途
US20140086975A1 (en) 2010-10-15 2014-03-27 Rutgers, The State University Of New Jersey Hydrogel formulation for dermal and ocular delivery
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN105601641B (zh) * 2015-12-22 2018-01-16 兰州大学 7‑位哌嗪磺酰胺喜树碱类化合物、制备方法及用途
CN106478648B (zh) * 2016-09-21 2018-11-06 桑迪亚医药技术（上海）有限责任公司 一种高喜树碱化合物及其合成方法
CN111777608B (zh) * 2020-07-08 2021-08-03 湖北精瑜材料有限公司 一种新型植物改性喹啉季铵盐化合物和制备方法及应用
WO2023232145A1 (zh) * 2022-06-02 2023-12-07 华东师范大学 一种高喜树碱类小分子及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162532A (en) * 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs

Also Published As

Publication number Publication date
IL128044A0 (en) 1999-11-30
HK1015783A1 (en) 1999-10-22
CL2004001168A1 (es) 2005-05-20
KR100440838B1 (ko) 2004-12-17
ATE312105T1 (de) 2005-12-15
NO316749B1 (no) 2004-04-26
EP1251125A2 (fr) 2002-10-23
RU2164515C2 (ru) 2001-03-27
EP0835258A1 (fr) 1998-04-15
DE69635560T2 (de) 2006-08-17
IL122635A (en) 2001-10-31
MX9710228A (es) 1998-03-31
CZ415397A3 (cs) 1998-08-12
NO975988D0 (no) 1997-12-19
CA2225528A1 (fr) 1997-01-09
KR19990028263A (ko) 1999-04-15
JP3576171B2 (ja) 2004-10-13
DE69623961D1 (de) 2002-10-31
DK0835258T3 (da) 2003-02-03
CN1114608C (zh) 2003-07-16
JPH11508249A (ja) 1999-07-21
HK1056726A1 (en) 2004-02-27
BR9608639A (pt) 1999-06-29
EP0835258B1 (fr) 2002-09-25
IL122635A0 (en) 1998-08-16
HK1050686A1 (en) 2003-07-04
NZ312715A (en) 2000-01-28
AU716377B2 (en) 2000-02-24
PL324339A1 (en) 1998-05-25
CN1192740A (zh) 1998-09-09
ATE224900T1 (de) 2002-10-15
PL185354B1 (pl) 2003-04-30
TW457234B (en) 2001-10-01
DK1251125T3 (da) 2006-04-18
RO117918B1 (ro) 2002-09-30
DE69623961T2 (de) 2003-05-08
CZ296156B6 (cs) 2006-01-11
PT835258E (pt) 2003-02-28
EP1251125A3 (fr) 2002-12-11
JP2004123756A (ja) 2004-04-22
WO1997000876A1 (fr) 1997-01-09
EP1251125B1 (fr) 2005-12-07
ES2184882T3 (es) 2003-04-16
ES2254600T3 (es) 2006-06-16
DE69635560D1 (de) 2006-01-12
AU6460896A (en) 1997-01-22
CA2225528C (fr) 2007-06-05

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