FR2757515B1 - Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant - Google Patents

Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Info

Publication number
FR2757515B1
FR2757515B1 FR9615775A FR9615775A FR2757515B1 FR 2757515 B1 FR2757515 B1 FR 2757515B1 FR 9615775 A FR9615775 A FR 9615775A FR 9615775 A FR9615775 A FR 9615775A FR 2757515 B1 FR2757515 B1 FR 2757515B1
Authority
FR
France
Prior art keywords
prodrougal
medicaments
processes
preparation
forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9615775A
Other languages
English (en)
Other versions
FR2757515A1 (fr
Inventor
Dennis Bigg
Olivier Lavergne
Jerry Harnett
Alain Rolland
Anne Marie Liberatore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority to FR9615775A priority Critical patent/FR2757515B1/fr
Priority to UA99063448A priority patent/UA57757C2/uk
Priority to AU53264/98A priority patent/AU734512B2/en
Priority to PL97334092A priority patent/PL188109B1/pl
Priority to ES97950235T priority patent/ES2206760T3/es
Priority to HU0001385A priority patent/HUP0001385A3/hu
Priority to CA2275345A priority patent/CA2275345C/fr
Priority to EP97950235A priority patent/EP0946566B1/fr
Priority to PCT/FR1997/002217 priority patent/WO1998028304A1/fr
Priority to BRPI9713977-7A priority patent/BR9713977B1/pt
Priority to RU99115884/04A priority patent/RU2190613C2/ru
Priority to NZ335938A priority patent/NZ335938A/xx
Priority to CN97180816A priority patent/CN1090634C/zh
Priority to DE69726007T priority patent/DE69726007T2/de
Priority to IL12989297A priority patent/IL129892A0/xx
Priority to AT97950235T priority patent/ATE253582T1/de
Priority to PT97950235T priority patent/PT946566E/pt
Priority to KR10-1999-7005604A priority patent/KR100516873B1/ko
Priority to JP52844798A priority patent/JP3576174B2/ja
Priority to CZ0209299A priority patent/CZ299794B6/cs
Priority to DK97950235T priority patent/DK0946566T3/da
Priority to ZA9711270A priority patent/ZA9711270B/xx
Priority to ARP970106042A priority patent/AR005849A1/es
Priority to TW086119342A priority patent/TW410224B/zh
Priority to MYPI97006216A priority patent/MY122042A/en
Publication of FR2757515A1 publication Critical patent/FR2757515A1/fr
Priority to IL129892A priority patent/IL129892A/en
Priority to US09/332,520 priority patent/US6339091B1/en
Priority to NO19992997A priority patent/NO324973B1/no
Application granted granted Critical
Publication of FR2757515B1 publication Critical patent/FR2757515B1/fr
Priority to HK00104033A priority patent/HK1024694A1/xx
Priority to US09/612,382 priority patent/US6797715B1/en
Priority to US10/061,049 priority patent/US6762301B2/en
Priority to US10/071,046 priority patent/US6815546B2/en
Priority to US10/862,245 priority patent/US7053102B2/en
Priority to US10/930,622 priority patent/US7135478B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9615775A 1995-06-21 1996-12-20 Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant Expired - Fee Related FR2757515B1 (fr)

Priority Applications (34)

Application Number Priority Date Filing Date Title
FR9615775A FR2757515B1 (fr) 1996-12-20 1996-12-20 Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
UA99063448A UA57757C2 (uk) 1996-12-20 1997-05-12 Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
KR10-1999-7005604A KR100516873B1 (ko) 1996-12-20 1997-12-05 캄프토테신의 전구약 및 유사체, 그의 의약으로서의 용도
ES97950235T ES2206760T3 (es) 1996-12-20 1997-12-05 Forma profarmacos y analogos de la campotecina, su aplicacion como medicamentos.
DK97950235T DK0946566T3 (da) 1996-12-20 1997-12-05 Prodrugformer og camptothecinanaloger og deres anvendelse som lægemidler
CA2275345A CA2275345C (fr) 1996-12-20 1997-12-05 Formes prodrogues et analogues de la camptothecine, leur application comme medicaments
EP97950235A EP0946566B1 (fr) 1996-12-20 1997-12-05 Formes prodrogues et analogues de la camptothecine, leur application comme medicaments
PCT/FR1997/002217 WO1998028304A1 (fr) 1996-12-20 1997-12-05 Formes prodrogues et analogues de la camptothecine, leur application comme medicaments
BRPI9713977-7A BR9713977B1 (pt) 1996-12-20 1997-12-05 composto análogo de comptotecina, e, utilização e processo para preparação do mesmo.
RU99115884/04A RU2190613C2 (ru) 1996-12-20 1997-12-05 Аналоги камптотецина, способы их получения и фармацевтическая композиция на их основе
NZ335938A NZ335938A (en) 1996-12-20 1997-12-05 Prodrug forms and new analogues of camptothecin, their use as medicaments
CN97180816A CN1090634C (zh) 1996-12-20 1997-12-05 喜树碱的前药形式和类似物,及其药物用途
DE69726007T DE69726007T2 (de) 1996-12-20 1997-12-05 Prodrogs und analoga von camptothecin und deren verwendung als arzneimittel
IL12989297A IL129892A0 (en) 1996-12-20 1997-12-05 Prodrug forms and new analogues of camptothecin and their use as medicaments
AT97950235T ATE253582T1 (de) 1996-12-20 1997-12-05 Prodrogs und analoga von camptothecin und deren verwendung als arzneimittel
PT97950235T PT946566E (pt) 1996-12-20 1997-12-05 Formas pro-farmacos e analogos da camptotecina sua aplicacao como medicamentos
PL97334092A PL188109B1 (pl) 1996-12-20 1997-12-05 Nowe analogi kamptotecyny, sposoby ich wytwarzania, ich zastosowanie jako leków oraz zawierające jekompozycje farmaceutyczne
JP52844798A JP3576174B2 (ja) 1996-12-20 1997-12-05 カンプトテシンのプロドラッグ型及び新規な同族体、その医薬としての用途
AU53264/98A AU734512B2 (en) 1996-12-20 1997-12-05 Prodrug forms and new analogues of camptothecin, their use as medicaments
HU0001385A HUP0001385A3 (en) 1996-12-20 1997-12-05 Pro-drugs and derivatives of camptothecin, process for their preparation, use thereof and pharmaceutical compositions containing them
CZ0209299A CZ299794B6 (cs) 1996-12-20 1997-12-05 Analogy kamptothecinu, zpusob jejich prípravy a farmaceutické prostredky obsahující tyto analogy
ZA9711270A ZA9711270B (en) 1996-12-20 1997-12-15 Precursory forms and new analogues of camptothecin, the processes for their preparation, their medical application and the pharmaceutical substances that contain them.
ARP970106042A AR005849A1 (es) 1996-12-20 1997-12-19 Un compuesto de camptotecina, un medicamento, una composicion farmaceutica que lo comprende y un procedimiento de preparacion del compuesto
TW086119342A TW410224B (en) 1996-12-20 1997-12-19 Precursory forms and new analogues of camptothecin, the processes for their preparation, their medical application and the pharmaceutical substances that contain them
MYPI97006216A MY122042A (en) 1996-12-20 1997-12-20 Pro-drugs and counterparts of camptothecin, their application as medicines
IL129892A IL129892A (en) 1996-12-20 1999-05-11 History of Homologues of Campacetcin, their Preparation and Pharmaceutical Preparations Containing Them
US09/332,520 US6339091B1 (en) 1995-06-21 1999-06-14 Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
NO19992997A NO324973B1 (no) 1996-12-20 1999-06-18 Camptothecinforbindelser samt anvendelse og fremstilling derav, medikament og farmasoytisk sammensetning.
HK00104033A HK1024694A1 (en) 1996-12-20 2000-07-04 Pro-drugs and counterparts of camptothecin, their application as medicines
US09/612,382 US6797715B1 (en) 1995-06-21 2000-07-07 Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
US10/061,049 US6762301B2 (en) 1995-06-21 2002-01-30 Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
US10/071,046 US6815546B2 (en) 1995-06-21 2002-02-06 Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
US10/862,245 US7053102B2 (en) 1995-06-21 2004-06-07 Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them
US10/930,622 US7135478B2 (en) 1995-06-21 2004-08-31 Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615775A FR2757515B1 (fr) 1996-12-20 1996-12-20 Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
FR2757515A1 FR2757515A1 (fr) 1998-06-26
FR2757515B1 true FR2757515B1 (fr) 2000-05-05

Family

ID=9498939

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9615775A Expired - Fee Related FR2757515B1 (fr) 1995-06-21 1996-12-20 Formes prodrogues et nouveaux analogues de la camptothecine, leurs procedes de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant

Country Status (3)

Country Link
FR (1) FR2757515B1 (fr)
RU (1) RU2190613C2 (fr)
ZA (1) ZA9711270B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (fr) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
ITMI20061473A1 (it) * 2006-07-26 2008-01-27 Indena Spa Derivati della camptotecina ad attivita antitumorale

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT835258E (pt) * 1995-06-21 2003-02-28 Sod Conseils Rech Applic Novos analogos de camptotecina, processos para a sua preparacao, sua utilizacao como farmacos e composicoes farmaceuticas que os contem

Also Published As

Publication number Publication date
FR2757515A1 (fr) 1998-06-26
ZA9711270B (en) 1998-06-23
RU2190613C2 (ru) 2002-10-10

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Legal Events

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CA Change of address
CD Change of name or company name
ST Notification of lapse

Effective date: 20120831