FR2803299B1 - NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION - Google Patents

NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION

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Publication number
FR2803299B1
FR2803299B1 FR0000095A FR0000095A FR2803299B1 FR 2803299 B1 FR2803299 B1 FR 2803299B1 FR 0000095 A FR0000095 A FR 0000095A FR 0000095 A FR0000095 A FR 0000095A FR 2803299 B1 FR2803299 B1 FR 2803299B1
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FR
France
Prior art keywords
preparation
methods
pharmaceutical compositions
same
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0000095A
Other languages
English (en)
Other versions
FR2803299A1 (fr
Inventor
Catherine Burnouf
Amaya Berecibar
Michel Navet
Horace A Dewald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority to FR0000095A priority Critical patent/FR2803299B1/fr
Priority to DZ000158A priority patent/DZ3103A1/fr
Priority to CZ20022222A priority patent/CZ20022222A3/cs
Priority to NZ519520A priority patent/NZ519520A/en
Priority to PCT/EP2000/013380 priority patent/WO2001049689A2/fr
Priority to SK940-2002A priority patent/SK9402002A3/sk
Priority to AT00991657T priority patent/ATE278692T1/de
Priority to MXPA02006618A priority patent/MXPA02006618A/es
Priority to DE60014712T priority patent/DE60014712T2/de
Priority to OA1200200203A priority patent/OA12134A/en
Priority to IL15039400A priority patent/IL150394A0/xx
Priority to EEP200200373A priority patent/EE200200373A/xx
Priority to CN00818202A priority patent/CN1420888A/zh
Priority to JP2001550229A priority patent/JP2003519233A/ja
Priority to PL00356668A priority patent/PL356668A1/xx
Priority to CA002396315A priority patent/CA2396315A1/fr
Priority to HU0204213A priority patent/HUP0204213A2/hu
Priority to BR0016926-9A priority patent/BR0016926A/pt
Priority to US10/169,375 priority patent/US6962912B2/en
Priority to AU33678/01A priority patent/AU3367801A/en
Priority to APAP/P/2002/002572A priority patent/AP2002002572A0/en
Priority to TR2002/01719T priority patent/TR200201719T2/xx
Priority to EA200200610A priority patent/EA005071B1/ru
Priority to ES00991657T priority patent/ES2226978T3/es
Priority to KR1020027008692A priority patent/KR20020063293A/ko
Priority to EP00991657A priority patent/EP1248787B1/fr
Priority to ARP010100024A priority patent/AR032298A1/es
Priority to PE2001000003A priority patent/PE20011041A1/es
Priority to TNTNSN01001A priority patent/TNSN01001A1/fr
Priority to UY26517A priority patent/UY26517A1/es
Priority to PA20018509601A priority patent/PA8509601A1/es
Priority to GT200100002A priority patent/GT200100002A/es
Priority to HN2001000002A priority patent/HN2001000002A/es
Priority to SV2001000253A priority patent/SV2001000253A/es
Priority to CO01000514A priority patent/CO5290255A1/es
Publication of FR2803299A1 publication Critical patent/FR2803299A1/fr
Priority to IS6437A priority patent/IS6437A/is
Priority to CR6693A priority patent/CR6693A/es
Priority to BG106893A priority patent/BG106893A/xx
Priority to ZA200205287A priority patent/ZA200205287B/en
Priority to MA26719A priority patent/MA26863A1/fr
Priority to NO20023249A priority patent/NO20023249L/no
Priority to HR20020577A priority patent/HRP20020577A2/hr
Priority to HK03102129.7A priority patent/HK1050002A1/zh
Application granted granted Critical
Publication of FR2803299B1 publication Critical patent/FR2803299B1/fr
Priority to US11/050,526 priority patent/US7232816B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
FR0000095A 2000-01-05 2000-01-05 NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION Expired - Fee Related FR2803299B1 (fr)

Priority Applications (44)

Application Number Priority Date Filing Date Title
FR0000095A FR2803299B1 (fr) 2000-01-05 2000-01-05 NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
DZ000158A DZ3103A1 (fr) 2000-01-05 2000-12-23 Nouvelles pyrazolo Ä4,3-EÜdiazépines substituées, compositions pharmaceutiques les contenant, utili sation à titre de médicament et procédés pour leurs préparation.
CZ20022222A CZ20022222A3 (cs) 2000-01-05 2000-12-27 Nové substituované pyrazolo [4,3-e] diazepiny, farmaceutické kompozice obsahující tyto diazepiny, jejich použití jako léčiva a způsoby jejich přípravy
NZ519520A NZ519520A (en) 2000-01-05 2000-12-27 Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them
PCT/EP2000/013380 WO2001049689A2 (fr) 2000-01-05 2000-12-27 Nouvelles pyrazolo [4, 3-e]diazepines, compositions pharmaceutiques les contenant, utilisation comme produits medicaux et procedes de preparation
SK940-2002A SK9402002A3 (en) 2000-01-05 2000-12-27 Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them
AT00991657T ATE278692T1 (de) 2000-01-05 2000-12-27 Pyrazolo(4,3-e)diazepine, diese enthaltende pharmazeutische zubereitungen , ihre verwendung als arzneimittel und verfahren zu ihrer herstellung
MXPA02006618A MXPA02006618A (es) 2000-01-05 2000-12-27 Pirazolo[4,3-e]diazepinas sustituidas novedosas, composiciones farmaceuticas que las contienen, su uso como productos medicinales y procesos para prepararlas.
DE60014712T DE60014712T2 (de) 2000-01-05 2000-12-27 Pyrazolo[4,3-e]Diazepine, diese enthaltende pharmazeutische Zubereitungen, ihre Verwendung als Arzneimittel und Verfahren zu ihrer Herstellung
OA1200200203A OA12134A (en) 2000-01-05 2000-12-27 Novel substituted pyrazoloÄ4-3-eÜdiazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them.
IL15039400A IL150394A0 (en) 2000-01-05 2000-12-27 NOVEL SUBSTITUTED PYRAZOLO[4,3-e] DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESS FOR PREPARING THEM
EEP200200373A EE200200373A (et) 2000-01-05 2000-12-27 Uued asendatud pürasolo[4,3-e]diasepiinid, neid sisaldavad farmatseutilised kompositsioonid, nende kasutamine raviproduktidena ja nende valmistamise protsessid
CN00818202A CN1420888A (zh) 2000-01-05 2000-12-27 新型的取代吡唑并[4,3-e]二氮杂䓬、包含该类化合物的药物组合物、其作为药品的应用及其制备方法
JP2001550229A JP2003519233A (ja) 2000-01-05 2000-12-27 新規な置換ピラゾロ〔４，３−ｅ〕ジアゼピン、それらを含有する医薬組成物、医薬品としての使用、及びそれらの製造法
PL00356668A PL356668A1 (en) 2000-01-05 2000-12-27 Novel substituted pyrazolo[4,3-e
CA002396315A CA2396315A1 (fr) 2000-01-05 2000-12-27 Nouvelles pyrazolo [4, 3-e]diazepines, compositions pharmaceutiques les contenant, utilisation comme produits medicaux et procedes de preparation
HU0204213A HUP0204213A2 (hu) 2000-01-05 2000-12-27 Új, helyettesített pirazolo[4,3-e]diazepinek, az ezeket tartalmazó gyógyászati készítmények, alkalmazásuk, továbbá eljárások ezek előállítására
BR0016926-9A BR0016926A (pt) 2000-01-05 2000-12-27 Pirazolo[4,3-e]diazepinas substituidos, composições farmacêuticas contendo os mesmos, uso como produtos medicinais e processos para preparação dos mesmos
US10/169,375 US6962912B2 (en) 2000-01-05 2000-12-27 Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them
AU33678/01A AU3367801A (en) 2000-01-05 2000-12-27 Novel substituted pyrazolo(4,3-e)diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them
APAP/P/2002/002572A AP2002002572A0 (en) 2000-01-05 2000-12-27 Novel substituted pyrazol(4,3-e) diazepines, pharmaceutical compositions containing them, as medical products and processes for preparing them
TR2002/01719T TR200201719T2 (tr) 2000-01-05 2000-12-27 Yeni sübstitüe pirazolo[4,3-e]diazepinler, bunları ihtiva eden farmasötik terkipler, bunların tıbbi ürünler olarak kullanımı.
EA200200610A EA005071B1 (ru) 2000-01-05 2000-12-27 ЗАМЕЩЕННЫЕ ПИРАЗОЛО[4,3-e]ДИАЗЕПИНЫ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ИХ, И ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ ПРОДУКТОВ
ES00991657T ES2226978T3 (es) 2000-01-05 2000-12-27 Nuevas pirazol0(4,3e)diazepinas sustituidas, composiciones farmaceuticas que las contienen, uso como productos medicinales y procedimiento de preparacion.
KR1020027008692A KR20020063293A (ko) 2000-01-05 2000-12-27 신규 치환된 피라졸로[4,3-ｅ]디아제핀, 이를 포함하는제약 조성물, 이의 의약품으로서의 용도 및 제조 방법
EP00991657A EP1248787B1 (fr) 2000-01-05 2000-12-27 NOUVELLES PYRAZOLO [4,3-e]DIAZEPINES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION COMME PRODUITS MEDICAUX ET PROCEDES DE LEUR PREPARATION
ARP010100024A AR032298A1 (es) 2000-01-05 2001-01-03 Compuestos derivados de pirazolo[4,3-e]diazepinas, composicion farmaceutica que los contienen, su uso como productos medicinales y proceso para prepararlos
PE2001000003A PE20011041A1 (es) 2000-01-05 2001-01-03 PIRAZOLO[4,3-e]DIAZEPINAS SUSTITUIDAS NOVEDOSAS, COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN Y PROCESOS PARA PREPARARLAS
TNTNSN01001A TNSN01001A1 (fr) 2000-01-05 2001-01-03 NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
UY26517A UY26517A1 (es) 2000-01-05 2001-01-03 Pirazolo (4,3-e) diazepinas sustituidas novedosas, composiciones farmacéuticas que las contienen, su uso como productos medicinales y procesos para prepararlas
PA20018509601A PA8509601A1 (es) 2000-01-05 2001-01-03 "PIRAZOLO [4,3,e] DIAZEPINAS SUSTITUIDAS NOVEDOSAS, COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN, SU USO COMO PRODUCTOS MEDICINALES Y PROCESOS PARA PREPARARLAS
GT200100002A GT200100002A (es) 2000-01-05 2001-01-04 Pirazolo(4,3-e)diazepinas sustituidas novedosas, composiciones farmaceuticas que las contienen, su uso como productosmedicinales y procesos para prepararlas.
HN2001000002A HN2001000002A (es) 2000-01-05 2001-01-04 PIRAZOLO [4,3-e] DIAZEPINAS SUSTITUIDAS NOVEDOSAS, COMPOSICIONES FARMACEUTICAS QUE LAS CONTIENEN, SU USO COMO PRODUCTOS MEDICINALES Y PROCESOS PARA PREPARARLAS.
SV2001000253A SV2001000253A (es) 2000-01-05 2001-01-04 Pirazolo (4,3-e) diazepinas sustituidas novedosas, composiciones farmaceuticas que las contienen, su uso como productos medicinales y procesos para prepararlas
CO01000514A CO5290255A1 (es) 2000-01-05 2001-01-04 Pirazolo(4,3-e)diazepinas sustituidas novedosas, composiciones farmaceuticas que las contienen, su uso como productos medicinales y procesos para prepararlas
IS6437A IS6437A (is) 2000-01-05 2002-06-19 Ný setin pýrazóló [4,3-e]díazepín lyfjasamsetningar sem innihalda þau, notkun sem læknandi afurðir og aðferðir við framleiðslu þeirra
CR6693A CR6693A (es) 2000-01-05 2002-07-01 Pirazolo (4,3-e) diazepinas sustituidas novedosas, composiciones farmaceuticas que las contienen, su uso como productos medicinales y procesos para prepararlas
BG106893A BG106893A (en) 2000-01-05 2002-07-02 NOVEL SUBSTITUTED PYRAZOLO[4,3-e]DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESSES FOR PREPARING THEM
ZA200205287A ZA200205287B (en) 2000-01-05 2002-07-02 Novel substituted pyrazolo(4,3-e)diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them.
MA26719A MA26863A1 (fr) 2000-01-05 2002-07-03 Nouvelles pyrazolo [4,3-e] diazepines substituées, compositions pharmaceutiques les contenant, leur utilisation comme produits pharmaceutiques et procedes pour leur preparation
NO20023249A NO20023249L (no) 2000-01-05 2002-07-04 Nye substituerte pyrazolo(4,3-e)diazepiner, farmasöytiske preparater inneholdende disse, anvendelse som medisinske produkterog fremgangsmåter for fremstilling derav
HR20020577A HRP20020577A2 (en) 2000-01-05 2002-07-05 NOVEL SUBSTITUTED PYRAZOLO[4,3-e]DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESSES FOR PREPARING THEM
HK03102129.7A HK1050002A1 (zh) 2000-01-05 2003-03-24 嶄新的吡唑[4，3-e]二氮雜草代替品、含有上述物質的藥用合成物、作藥用產品的用途及其製造過程
US11/050,526 US7232816B2 (en) 2000-01-05 2005-02-02 Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them

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EP1188438A1 (fr) * 2000-09-15 2002-03-20 Warner-Lambert Company Compositions pharmaceutiques pour la prévention ou le traitement de maladies associées à un excès de production de l' IL-12
EP1199074A1 (fr) * 2000-09-15 2002-04-24 Warner-Lambert Company Composition pharmaceutique pour la prévention ou le traitement de maladies associées à un excès de production d' IL-12
AR058071A1 (es) * 2005-10-03 2008-01-23 Astrazeneca Ab Derivados de dihidropirazolo (3,4-e)(1,4)diazepina. procesos de obtencion y composiciones farmaceuticas.
KR20160080799A (ko) 2014-12-30 2016-07-08 한국해양과학기술원 금 촉매를 이용한 α-피론 유도체 전합성 방법 및 이에 의해 합성되어 인간 암세포주에 세포독성을 가지는 α-피론 유도체
JP6850886B2 (ja) 2016-12-12 2021-03-31 レオ ファーマ アクティーゼルスカブ 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用
US11065257B2 (en) 2016-12-12 2021-07-20 Leo Pharma A/S Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
US10793580B2 (en) 2016-12-12 2020-10-06 Leo Pharma A/S Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors
TWI812739B (zh) * 2018-06-21 2023-08-21 景凱生物科技股份有限公司 Nadph氧化酶抑制劑、含其的醫藥組合物、及其應用

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WO2001049689A2 (fr) 2001-07-12
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AU3367801A (en) 2001-07-16
EA200200610A1 (ru) 2002-12-26
CO5290255A1 (es) 2003-06-27
TR200201719T2 (tr) 2002-12-23
SK9402002A3 (en) 2003-08-05
IL150394A0 (en) 2002-12-01
BR0016926A (pt) 2002-11-19
AR032298A1 (es) 2003-11-05
EP1248787B1 (fr) 2004-10-06
DZ3103A1 (fr) 2004-06-20
FR2803299A1 (fr) 2001-07-06
EE200200373A (et) 2003-10-15
CR6693A (es) 2004-04-27
HK1050002A1 (zh) 2003-06-06
OA12134A (en) 2006-05-05
SV2001000253A (es) 2001-10-16
KR20020063293A (ko) 2002-08-01
DE60014712D1 (de) 2004-11-11
HN2001000002A (es) 2001-09-26
HUP0204213A2 (hu) 2003-04-28
ZA200205287B (en) 2003-07-02
HRP20020577A2 (en) 2003-12-31
PL356668A1 (en) 2004-06-28
UY26517A1 (es) 2001-03-16
DE60014712T2 (de) 2006-02-02
TNSN01001A1 (fr) 2005-11-10
BG106893A (en) 2003-04-30
MA26863A1 (fr) 2004-12-20
ATE278692T1 (de) 2004-10-15
NO20023249L (no) 2002-09-04
PE20011041A1 (es) 2001-10-12
WO2001049689A3 (fr) 2001-12-20
CZ20022222A3 (cs) 2003-05-14
JP2003519233A (ja) 2003-06-17
EP1248787A2 (fr) 2002-10-16
CA2396315A1 (fr) 2001-07-12
MXPA02006618A (es) 2002-09-30
AP2002002572A0 (en) 2002-09-30
ES2226978T3 (es) 2005-04-01
NO20023249D0 (no) 2002-07-04
EA005071B1 (ru) 2004-10-28
NZ519520A (en) 2004-02-27
IS6437A (is) 2002-06-19

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FR2803299B1 (fr) NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION

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