AR058071A1 - Derivados de dihidropirazolo (3,4-e)(1,4)diazepina. procesos de obtencion y composiciones farmaceuticas. - Google Patents
Derivados de dihidropirazolo (3,4-e)(1,4)diazepina. procesos de obtencion y composiciones farmaceuticas.Info
- Publication number
- AR058071A1 AR058071A1 ARP060104273A ARP060104273A AR058071A1 AR 058071 A1 AR058071 A1 AR 058071A1 AR P060104273 A ARP060104273 A AR P060104273A AR P060104273 A ARP060104273 A AR P060104273A AR 058071 A1 AR058071 A1 AR 058071A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- alkoxy
- halogen
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procesos para preparar dichos compuestos, el uso de dichos compuestos en el tratamiento de un estado de enfermedad mediado por PDE 4, y composiciones farmacéuticas que los contienen. Reivindicacion 1: Un compuesto caracterizado porque responde a la formula (1) donde R1 es un anillo carbocíclico o heterocíclico e 5 o 6 miembros, saturado o no saturado; cuando R1 es arilo o heteroarilo entonces dicho arilo o heteroarilo se sustituye opcionalmente como se muestra a continuacion; cuando R1 es un carbociclo no aromático o heterociclilo no aromático entonces dicho anillo esta opcionalmente sustituido con alquilo C1-6; R2 es alquilo C1-4, alcoxi C1-4 o alquiltio C1-4; R3 es H o alquilo C1-4; R4 es alquilo C1-6 (opcionalmente sustituido con CO2R26 o C(O)NR27R28), arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; R25 es H o fenilo opcionalmente sustituido; los anillos arilo, heteroarilo y fenilo mencionados se sustituyen opcionalmente en forma independiente con: halogeno, ciano, nitro, hidroxi, S(O)qR5, OC(O)NR6R7, NR8R9, NR10C(O)R11, NR12C(O)NR13R14, S(O)2NR15R16, NR17S(O)2R18, C(O)NR19R20, C(O)R21, CO2R22, NR23CO2R24, alquilo C1-6, haloalquilo C1-6 alcoxi C1-6-alquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alcoxi C1-6-alcoxi C1-6, alquiltio C1-6, O(CH2)nO, fenilalquilo C1-6, fenoxialquilo C1-6 o fenilalcoxi C1-6; los anillos fenilo de los ultimos tres sustituyentes se sustituyen opcionalmente con halogeno, alquilo C1-4, alcoxi C1-4, CF3 o OCF3; n es 1, 2 o 3; q es 0, 1 o 2; R6 y R7, R13 y R14, R15 y R16, o R19 y R20 se pueden unir para formar, con e N al cual están unidos, un anillo de 5 o 6 miembros; R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24 y R26 son, en forma independiente, alquilo C1-6, (opcionalmente sustituido con halogeno, hidroxi o alcoxi C1-6) o fenilo (él mismo opcionalmente sustituido con halogeno, alquilo C1-4, alcoxi C1-4, CF3 o OCF3); R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R19, R20, R21, R22, R23 y R26 pueden también ser H; R27 es H o alquilo C1-6; R28 es H o alquilo C1-6 (opcionalmente sustituido con NH2, NH(alquilo C1-6) o N(alquil C1-6)2); o un N-oxido de los mismos; o una sal aceptable para uso farmacéutico de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0502176 | 2005-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058071A1 true AR058071A1 (es) | 2008-01-23 |
Family
ID=37906399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104273A AR058071A1 (es) | 2005-10-03 | 2006-09-28 | Derivados de dihidropirazolo (3,4-e)(1,4)diazepina. procesos de obtencion y composiciones farmaceuticas. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090054413A1 (es) |
| EP (1) | EP1931672A1 (es) |
| JP (1) | JP2009510159A (es) |
| AR (1) | AR058071A1 (es) |
| TW (1) | TW200745106A (es) |
| UY (1) | UY29821A1 (es) |
| WO (1) | WO2007040435A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2694506T3 (es) * | 2009-03-12 | 2018-12-21 | Cumberland Pharmaceuticals Inc. | Administración de ibuprofeno por vía intravenosa |
| BRPI1012980A2 (pt) * | 2009-05-19 | 2016-03-29 | Vivia Biotech Sl | dispositivo e métodos para analisar a capacidade de resposta celular e a resposta de células neoplásticas a drogas |
| US8871810B2 (en) | 2009-07-15 | 2014-10-28 | Cumberland Pharmaceuticals Inc. | Treating critically ill patients with intravenous ibuprofen |
| US9072710B2 (en) | 2012-03-16 | 2015-07-07 | Cumberland Pharmaceuticals Inc. | Injectable ibuprofen formulation |
| US9072661B2 (en) | 2012-03-16 | 2015-07-07 | Cumberland Pharmaceuticals Inc. | Injectable ibuprofen formulation |
| US11065257B2 (en) | 2016-12-12 | 2021-07-20 | Leo Pharma A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
| ES2875128T3 (es) * | 2016-12-12 | 2021-11-08 | Union Therapeutics As | Pirazoloazepin-8-onas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| US10793580B2 (en) | 2016-12-12 | 2020-10-06 | Leo Pharma A/S | Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors |
| TWI812739B (zh) * | 2018-06-21 | 2023-08-21 | 景凱生物科技股份有限公司 | Nadph氧化酶抑制劑、含其的醫藥組合物、及其應用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20021151A3 (cs) * | 1999-10-11 | 2003-03-12 | Pfizer Inc. | 5-(2-substituovaný-5-heterocyklylsulfonylpyrid-3-yl)-dihydropyrazolo[4,3-d]-pyrimidin-7-ony jako inhibitory fosfodiesterasy |
| FR2803299B1 (fr) * | 2000-01-05 | 2004-09-17 | Warner Lambert Co | NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| KR100358083B1 (ko) * | 2000-02-17 | 2002-10-25 | 에스케이케미칼주식회사 | 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도 |
| GB0113344D0 (en) * | 2001-06-01 | 2001-07-25 | Bayer Ag | Novel heterocycles 3 |
| DE60222931T2 (de) * | 2001-12-13 | 2008-07-10 | Asubio Pharma Co., Ltd. | Pyrazolopyrimidinonderivate mit pde7-hemmender wirkung |
-
2006
- 2006-09-28 AR ARP060104273A patent/AR058071A1/es not_active Application Discontinuation
- 2006-09-28 TW TW095135979A patent/TW200745106A/zh unknown
- 2006-09-29 UY UY29821A patent/UY29821A1/es not_active Application Discontinuation
- 2006-10-02 WO PCT/SE2006/001111 patent/WO2007040435A1/en active Application Filing
- 2006-10-02 EP EP06799711A patent/EP1931672A1/en not_active Withdrawn
- 2006-10-02 JP JP2008534481A patent/JP2009510159A/ja active Pending
- 2006-10-02 US US12/088,552 patent/US20090054413A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| UY29821A1 (es) | 2007-05-31 |
| TW200745106A (en) | 2007-12-16 |
| JP2009510159A (ja) | 2009-03-12 |
| US20090054413A1 (en) | 2009-02-26 |
| WO2007040435A1 (en) | 2007-04-12 |
| EP1931672A1 (en) | 2008-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |