DE60000328D1 - Camptothecin Analoge Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen - Google Patents

Camptothecin Analoge Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Info

Publication number
DE60000328D1
DE60000328D1 DE60000328T DE60000328T DE60000328D1 DE 60000328 D1 DE60000328 D1 DE 60000328D1 DE 60000328 T DE60000328 T DE 60000328T DE 60000328 T DE60000328 T DE 60000328T DE 60000328 D1 DE60000328 D1 DE 60000328D1
Authority
DE
Germany
Prior art keywords
alkyl
aryl
groups
cycloalkyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60000328T
Other languages
English (en)
Other versions
DE60000328T2 (de
Inventor
Gilbert Lavielle
Patrick Hautefaye
Alain Pierre
Ghanem Atassi
John Hickman
Bernard Cimetiere
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Application granted granted Critical
Publication of DE60000328D1 publication Critical patent/DE60000328D1/de
Publication of DE60000328T2 publication Critical patent/DE60000328T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60000328T 1999-11-18 2000-11-09 Camptothecin Analoge Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen Expired - Lifetime DE60000328T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9914499A FR2801309B1 (fr) 1999-11-18 1999-11-18 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE60000328D1 true DE60000328D1 (de) 2002-09-19
DE60000328T2 DE60000328T2 (de) 2003-04-17

Family

ID=9552253

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60000328T Expired - Lifetime DE60000328T2 (de) 1999-11-18 2000-11-09 Camptothecin Analoge Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Country Status (23)

Country Link
US (1) US6509345B2 (de)
EP (1) EP1101765B1 (de)
JP (1) JP3545332B2 (de)
KR (1) KR100460785B1 (de)
CN (2) CN1304395C (de)
AT (1) ATE222253T1 (de)
AU (1) AU772609B2 (de)
BR (1) BR0005486A (de)
CA (1) CA2325776C (de)
DE (1) DE60000328T2 (de)
DK (1) DK1101765T3 (de)
EA (1) EA003206B1 (de)
ES (1) ES2180501T3 (de)
FR (1) FR2801309B1 (de)
HK (2) HK1036803A1 (de)
HU (1) HUP0004573A3 (de)
MX (1) MXPA00011238A (de)
NO (1) NO318464B1 (de)
NZ (1) NZ508248A (de)
PL (1) PL202231B1 (de)
PT (1) PT1101765E (de)
SI (1) SI1101765T1 (de)
ZA (1) ZA200006730B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1436293B1 (de) 2001-10-05 2006-02-01 F. Hoffmann-La Roche Ag Polycyclische verbindungen mit antitumor-wirkung
US7071204B2 (en) * 2003-06-30 2006-07-04 Research Triangle Institute Camptothecin analogs having an E-ring ketone
FR2889527A1 (fr) * 2005-08-05 2007-02-09 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892417B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a sept chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892418B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a six chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US8410045B2 (en) 2006-03-30 2013-04-02 Drais Pharmaceuticals, Inc. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
CN103288842B (zh) * 2012-02-24 2016-01-13 中国人民解放军第二军医大学 氟取代e环喜树碱类似物及其作为药物的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829793B2 (ja) * 1975-02-07 1983-06-24 日本ケミフア （株） ７−アルコキシカルボニル−８−メチルインドリジノ〔１，２−ｂ〕キノリン−９（１１Ｈ）−オンの製法
JPS58435B2 (ja) * 1975-12-23 1983-01-06 カメタニ テツジ ルテカルピンノセイホウ
GB8513460D0 (en) * 1985-05-29 1985-07-03 Glaxo Group Ltd Chemical compounds
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH06509175A (ja) * 1991-07-22 1994-10-13 アボツト・ラボラトリーズ 医療用自動分析装置用試薬処理システム
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
EP0835258B1 (de) * 1995-06-21 2002-09-25 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Camptothecinanaloge, verfahren zur ihrer herstellung, ihre verwendungals arzneimittel und diese enthaltende pharmazeutische zusammenfassungen
UA57757C2 (uk) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds

Also Published As

Publication number Publication date
CN1304395C (zh) 2007-03-14
MXPA00011238A (es) 2002-05-23
HUP0004573A2 (hu) 2001-09-28
AU772609B2 (en) 2004-05-06
SI1101765T1 (en) 2002-12-31
EP1101765A3 (de) 2001-10-04
CA2325776C (fr) 2007-02-20
ES2180501T3 (es) 2003-02-16
DK1101765T3 (da) 2002-12-16
AU7168300A (en) 2001-05-24
HU0004573D0 (de) 2001-02-28
FR2801309A1 (fr) 2001-05-25
PT1101765E (pt) 2002-11-29
JP2001151776A (ja) 2001-06-05
HUP0004573A3 (en) 2002-06-28
HK1071892A1 (en) 2005-08-05
EP1101765B1 (de) 2002-08-14
HK1036803A1 (en) 2002-01-18
US20020077325A1 (en) 2002-06-20
CN1158282C (zh) 2004-07-21
FR2801309B1 (fr) 2002-01-04
US6509345B2 (en) 2003-01-21
PL202231B1 (pl) 2009-06-30
EA003206B1 (ru) 2003-02-27
EA200001084A1 (ru) 2001-06-25
NO318464B1 (no) 2005-03-21
PL343949A1 (en) 2001-05-21
KR20010051779A (ko) 2001-06-25
BR0005486A (pt) 2001-08-07
ATE222253T1 (de) 2002-08-15
NZ508248A (en) 2001-08-31
JP3545332B2 (ja) 2004-07-21
CN1301701A (zh) 2001-07-04
ZA200006730B (en) 2001-05-31
CA2325776A1 (fr) 2001-05-18
DE60000328T2 (de) 2003-04-17
EP1101765A2 (de) 2001-05-23
NO20005807L (no) 2001-05-21
CN1552712A (zh) 2004-12-08
KR100460785B1 (ko) 2004-12-09
NO20005807D0 (no) 2000-11-17

Similar Documents

Publication Publication Date Title
HK1071892A1 (en) New camptothecin analogue compounds, a process fortheir preparation and pharmaceutical compositions containing them
CO5031253A1 (es) Antagonistas receptores y5 de neuropeptidos composiciones farmaceuticas que las contienen
ATE186548T1 (de) Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
AR031526A1 (es) Nuevas fenilpiperazinas, composiciones farmaceuticas que las contienen, metodos para preparar los compuestos y las composiciones y uso de los compuestos en la preparacion de un medicamento.
ATE266664T1 (de) Pyridinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE69717044T2 (de) Flavone-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
DE69801400D1 (de) Chromenderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
CY1106396T1 (el) Γραμμικες ή κυκλικες ουριες, μεθοδος παρασκευης αυτων και φαρμακευτικες συνθεσεις οι οποιες τις πepιεχουν
HUP0004546A2 (hu) N-fenilamid- és N-piridilamid-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
DE69803894T2 (de) Heterozyclische Verbindungen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
ATE291577T1 (de) Cyanoindol-derivate als inhibitoren der wiederaufnahme von serotonin, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
ATE215080T1 (de) 1,2-dithiolan derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
ATE216392T1 (de) 7-oxo-2,3,7,14-tetrahydro-1h-benzo(b)pyrano(3,2 h)acridincarboxylatderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE69702580D1 (de) Hydrochinon-Derivate und deren pharmazeutische Verwendung
ATE242201T1 (de) Substituierte dimere verbindungen verfahren zu deren herstellung und deren pharmazeutischen zusammensetzungen
ATE195936T1 (de) Bis-imide derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitung
DE69706206T2 (de) Von Neurokininen abgeleitete Pseudopeptide, Verfahren für ihre Herstellung und sie enthaltende pharmazeutische Zubereitungen
UY28119A1 (es) Nuevos derivados que contienen fosforo
HUP9903319A3 (en) 2-hetaroylcyclohexane-1,3-dione derivatives, use thereof and herbicide compositions containing these compounds
DE69407227D1 (de) Die Verwendung von 2-Phenylmethylene-1-3'-(amino)-2-(hydroxy)-propoxy-imino-cyclohexane-Derivaten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition