DOP2006000233A - Inhibidores de cinasa - Google Patents

Inhibidores de cinasa

Info

Publication number
DOP2006000233A
DOP2006000233A DO2006000233A DO2006000233A DOP2006000233A DO P2006000233 A DOP2006000233 A DO P2006000233A DO 2006000233 A DO2006000233 A DO 2006000233A DO 2006000233 A DO2006000233 A DO 2006000233A DO P2006000233 A DOP2006000233 A DO P2006000233A
Authority
DO
Dominican Republic
Prior art keywords
kinase inhibitors
formula
pharmaceutically acceptable
acceptable salt
present
Prior art date
Application number
DO2006000233A
Other languages
English (en)
Inventor
Alfonso De Dios
De Uralde Garmendia Beatriz Lopez
Mary Margaret Mader
Mark Andrew Pobanz
Chuan Nmn Shih
Boyu Zhong
Cristina Garcia-Paredes
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43298632&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2006000233(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DOP2006000233A publication Critical patent/DOP2006000233A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona inhibidores de cinasa de Fórmula I: Fórmula I en donde R1, R2 y X son como se describen en este documento, o una sal del mismo farmacéuticamente aceptable
DO2006000233A 2005-10-28 2006-10-20 Inhibidores de cinasa DOP2006000233A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05380240 2005-10-28
US75020005P 2005-12-14 2005-12-14
EP06380097 2006-04-26
US82196406P 2006-08-10 2006-08-10

Publications (1)

Publication Number Publication Date
DOP2006000233A true DOP2006000233A (es) 2007-06-15

Family

ID=43298632

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2006000233A DOP2006000233A (es) 2005-10-28 2006-10-20 Inhibidores de cinasa

Country Status (13)

Country Link
US (1) US7582638B2 (es)
EP (1) EP1943244A1 (es)
JP (1) JP2009513639A (es)
KR (1) KR101013303B1 (es)
AR (1) AR058128A1 (es)
AU (1) AU2006309174B2 (es)
BR (1) BRPI0617828A2 (es)
CA (1) CA2627670A1 (es)
DO (1) DOP2006000233A (es)
EA (1) EA015123B1 (es)
PE (1) PE20070640A1 (es)
TW (1) TW200800194A (es)
WO (1) WO2007053346A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101636397B (zh) * 2007-04-13 2012-06-13 中国人民解放军军事医学科学院毒物药物研究所 脲类化合物、其制备方法及其医药用途
EP2039676A1 (en) * 2007-09-19 2009-03-25 Huntsman International Llc Process for the production of di-and polyamines of the diphenylmethane series
EP2578582A1 (en) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
JP2014528404A (ja) 2011-10-03 2014-10-27 レスピバート・リミテツド ｐ３８ＭＡＰキナーゼ阻害剤としての１−ピラゾリル−３−（４−（（２−アニリノピリミジン−４−イル）オキシ）ナフタレン−１−イル）尿素
GB201214750D0 (en) 2012-08-17 2012-10-03 Respivert Ltd Compounds
EP2925742B1 (en) 2012-11-16 2016-10-26 Respivert Limited Kinase inhibitors
EP2970190A1 (en) 2013-03-14 2016-01-20 Respivert Limited Kinase inhibitors
RU2019133646A (ru) 2017-03-30 2021-04-30 Ф. Хоффманн-Ля Рош Аг Изохинолины в качестве ингибиторов hpk1
NZ762856A (en) 2017-10-05 2020-07-31 Fulcrum Therapeutics Inc P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73492C2 (en) * 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
JP2005538975A (ja) * 2002-07-03 2005-12-22 アステックス テクノロジー リミテッド ｐ３８ＭＡＰキナーゼ阻害薬としての３−（ヘテロ）アリールメトキシピリジン類およびそれらの類縁体
EP1609789A1 (en) 2004-06-23 2005-12-28 Eli Lilly And Company Ureido-pyrazole derivatives and their use as kinase inhibitors
DK1761520T3 (da) * 2004-06-23 2008-10-27 Lilly Co Eli Kinaseinhibitorer

Also Published As

Publication number Publication date
AU2006309174A1 (en) 2007-05-10
KR20080053514A (ko) 2008-06-13
US7582638B2 (en) 2009-09-01
WO2007053346A1 (en) 2007-05-10
EA200801200A1 (ru) 2008-08-29
JP2009513639A (ja) 2009-04-02
EA015123B1 (ru) 2011-06-30
PE20070640A1 (es) 2007-08-10
AU2006309174B2 (en) 2011-10-13
CA2627670A1 (en) 2007-05-10
BRPI0617828A2 (pt) 2011-08-09
US20080275056A1 (en) 2008-11-06
KR101013303B1 (ko) 2011-02-09
AR058128A1 (es) 2008-01-23
TW200800194A (en) 2008-01-01
EP1943244A1 (en) 2008-07-16

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