ATE528290T1 - Spiroindolinon-derivate - Google Patents
Spiroindolinon-derivateInfo
- Publication number
- ATE528290T1 ATE528290T1 AT09722134T AT09722134T ATE528290T1 AT E528290 T1 ATE528290 T1 AT E528290T1 AT 09722134 T AT09722134 T AT 09722134T AT 09722134 T AT09722134 T AT 09722134T AT E528290 T1 ATE528290 T1 AT E528290T1
- Authority
- AT
- Austria
- Prior art keywords
- spiroindolinone derivatives
- spiroindolinone
- derivatives
- compounds
- general formulas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3779908P | 2008-03-19 | 2008-03-19 | |
| PCT/EP2009/052737 WO2009115425A1 (en) | 2008-03-19 | 2009-03-09 | Spiroindolinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE528290T1 true ATE528290T1 (de) | 2011-10-15 |
Family
ID=40595697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09722134T ATE528290T1 (de) | 2008-03-19 | 2009-03-09 | Spiroindolinon-derivate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7723372B2 (de) |
| EP (1) | EP2265583B1 (de) |
| JP (1) | JP2011515353A (de) |
| KR (1) | KR20100121521A (de) |
| CN (1) | CN101977898A (de) |
| AT (1) | ATE528290T1 (de) |
| AU (1) | AU2009226866A1 (de) |
| BR (1) | BRPI0909333A2 (de) |
| CA (1) | CA2716979A1 (de) |
| ES (1) | ES2373857T3 (de) |
| IL (1) | IL208025A0 (de) |
| MX (1) | MX2010009927A (de) |
| WO (1) | WO2009115425A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104876938A (zh) | 2009-11-12 | 2015-09-02 | 密歇根大学董事会 | 螺-吲哚酮mdm2拮抗剂 |
| PE20140408A1 (es) | 2010-11-12 | 2014-04-10 | Univ Michigan | Derivados espiro-oxindol como antagonistas de mdm2 |
| TR201807311T4 (tr) | 2011-03-10 | 2018-06-21 | Daiichi Sankyo Co Ltd | Dispiropirolidin derivesi. |
| CN102180828A (zh) * | 2011-03-31 | 2011-09-14 | 四川大学 | 手性吲哚啉酮螺五环骨架化合物及不对称合成 |
| MX346375B (es) | 2011-05-11 | 2017-03-16 | Univ Michigan Regents | Antagonistas de espiro-oxindol de mdm2. |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| CN103172555B (zh) * | 2012-12-07 | 2014-07-09 | 山东绿叶制药有限公司 | 升麻中分离的吲哚生物碱化合物、制备方法及其用途 |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| EP3511334A1 (de) * | 2018-01-16 | 2019-07-17 | Adamed sp. z o.o. | 1,2,3',5'-tetrahydro-2'h-spiro[indol-3,1'-pyrrolo[3,4-c]pyrrol] -2,3'-dion-verbindungen als therapeutische mittel, die tp53 aktivieren |
| WO2022183006A1 (en) | 2021-02-25 | 2022-09-01 | Mayo Foundation For Medical Education And Research | Compounds for programmable protein degradation and methods of use for the disease treatment |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5114937A (en) * | 1989-11-28 | 1992-05-19 | Warner-Lambert Company | Renin inhibiting nonpeptides |
| FR2740136B1 (fr) | 1995-10-24 | 1998-01-09 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
| GB9819860D0 (en) * | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
| AU2006216780B8 (en) * | 2005-02-22 | 2010-04-22 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and uses thereof |
| US7495007B2 (en) * | 2006-03-13 | 2009-02-24 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US20070213341A1 (en) * | 2006-03-13 | 2007-09-13 | Li Chen | Spiroindolinone derivatives |
| US7638548B2 (en) * | 2006-11-09 | 2009-12-29 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US20080188506A1 (en) | 2007-02-07 | 2008-08-07 | Qingjie Ding | Spiroindolinone derivatives |
| US7553833B2 (en) | 2007-05-17 | 2009-06-30 | Hoffmann-La Roche Inc. | 3,3-spiroindolinone derivatives |
| US7834179B2 (en) | 2007-05-23 | 2010-11-16 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
-
2009
- 2009-02-18 US US12/372,926 patent/US7723372B2/en not_active Expired - Fee Related
- 2009-03-09 AT AT09722134T patent/ATE528290T1/de not_active IP Right Cessation
- 2009-03-09 EP EP09722134A patent/EP2265583B1/de not_active Not-in-force
- 2009-03-09 MX MX2010009927A patent/MX2010009927A/es active IP Right Grant
- 2009-03-09 CN CN2009801094982A patent/CN101977898A/zh active Pending
- 2009-03-09 JP JP2011500149A patent/JP2011515353A/ja active Pending
- 2009-03-09 AU AU2009226866A patent/AU2009226866A1/en not_active Abandoned
- 2009-03-09 CA CA2716979A patent/CA2716979A1/en not_active Abandoned
- 2009-03-09 BR BRPI0909333A patent/BRPI0909333A2/pt not_active IP Right Cessation
- 2009-03-09 KR KR1020107021030A patent/KR20100121521A/ko not_active Ceased
- 2009-03-09 ES ES09722134T patent/ES2373857T3/es active Active
- 2009-03-09 WO PCT/EP2009/052737 patent/WO2009115425A1/en not_active Ceased
-
2010
- 2010-09-06 IL IL208025A patent/IL208025A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009115425A1 (en) | 2009-09-24 |
| CN101977898A (zh) | 2011-02-16 |
| IL208025A0 (en) | 2010-12-30 |
| MX2010009927A (es) | 2010-09-30 |
| US20090239889A1 (en) | 2009-09-24 |
| EP2265583B1 (de) | 2011-10-12 |
| ES2373857T3 (es) | 2012-02-09 |
| US7723372B2 (en) | 2010-05-25 |
| EP2265583A1 (de) | 2010-12-29 |
| BRPI0909333A2 (pt) | 2019-09-24 |
| AU2009226866A1 (en) | 2009-09-24 |
| KR20100121521A (ko) | 2010-11-17 |
| JP2011515353A (ja) | 2011-05-19 |
| CA2716979A1 (en) | 2009-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |