PE20140408A1 - Derivados espiro-oxindol como antagonistas de mdm2 - Google Patents

Derivados espiro-oxindol como antagonistas de mdm2

Info

Publication number
PE20140408A1
PE20140408A1 PE2013001063A PE2013001063A PE20140408A1 PE 20140408 A1 PE20140408 A1 PE 20140408A1 PE 2013001063 A PE2013001063 A PE 2013001063A PE 2013001063 A PE2013001063 A PE 2013001063A PE 20140408 A1 PE20140408 A1 PE 20140408A1
Authority
PE
Peru
Prior art keywords
alkyl
mdm2
spiro
antagonists
oxindol
Prior art date
Application number
PE2013001063A
Other languages
English (en)
Inventor
Shaomeng Wang
Yujun Zhao
Wei Sun
Sanjeev Kumar
Lance Leopold
Laurent Debussche
Cedric Barriere
Jean-Christophe Carry
Kwame Amaning
Ming Guo
Original Assignee
Univ Michigan
Ascenta Licensing Corp
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, Ascenta Licensing Corp, Sanofi Sa filed Critical Univ Michigan
Publication of PE20140408A1 publication Critical patent/PE20140408A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN DERIVADO ESPIRO-OXINDOL DE FORMULA (XII), DONDE R1a, R1b, R1c Y R1d SON H, F Y Cl; R2 ES ARALQUILO O UN FENILO SUSTITUIDO; R25a, R25b, R25c, R25d Y R25e SON H, F O Cl; R3 ES ALQUILO C1-C8, ARILO, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, ENTRE OTROS; R5 ES CICLOBUTANOL, ETILCICLOHEXANOL, ENTRE OTROS; X ES O, S Y NR'; Y ES O, S Y NR''; R' ES H, ALQUILO C1-C4, ENTRE OTROS; R'' ES H, ALQUILO C1-C4, COCH3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (a), (b), (c), ENTRE OTROS; TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD ANTAGONISTA DE LA INTERACCION ENTRE p53 Y MDM2 Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS CELULARES TALES COMO EL CANCER
PE2013001063A 2010-11-12 2011-11-11 Derivados espiro-oxindol como antagonistas de mdm2 PE20140408A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41309410P 2010-11-12 2010-11-12
US201161451968P 2011-03-11 2011-03-11
US201161451958P 2011-03-11 2011-03-11
US201161470992P 2011-04-01 2011-04-01

Publications (1)

Publication Number Publication Date
PE20140408A1 true PE20140408A1 (es) 2014-04-10

Family

ID=46048358

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013001063A PE20140408A1 (es) 2010-11-12 2011-11-11 Derivados espiro-oxindol como antagonistas de mdm2

Country Status (26)

Country Link
US (2) US8680132B2 (es)
EP (1) EP2638046A4 (es)
JP (1) JP2014500870A (es)
KR (1) KR101929188B1 (es)
CN (1) CN103298818B (es)
AR (1) AR083849A1 (es)
AU (1) AU2011326395B2 (es)
CA (1) CA2817585A1 (es)
CO (1) CO6721010A2 (es)
CR (1) CR20130271A (es)
DO (1) DOP2013000104A (es)
EA (1) EA201390682A1 (es)
EC (1) ECSP13012678A (es)
GT (1) GT201300118A (es)
IL (1) IL226275A0 (es)
MA (1) MA34732B1 (es)
MX (1) MX2013005238A (es)
NI (1) NI201300041A (es)
NZ (1) NZ611866A (es)
PE (1) PE20140408A1 (es)
SG (1) SG190230A1 (es)
TW (1) TWI535723B (es)
UA (1) UA109464C2 (es)
UY (1) UY33725A (es)
WO (1) WO2012065022A2 (es)
ZA (1) ZA201304042B (es)

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