MA34732B1 - Spiro-oxindoles antagonistes de mdm2 - Google Patents
Spiro-oxindoles antagonistes de mdm2Info
- Publication number
- MA34732B1 MA34732B1 MA36005A MA36005A MA34732B1 MA 34732 B1 MA34732 B1 MA 34732B1 MA 36005 A MA36005 A MA 36005A MA 36005 A MA36005 A MA 36005A MA 34732 B1 MA34732 B1 MA 34732B1
- Authority
- MA
- Morocco
- Prior art keywords
- oxindoles
- mdm2
- spiro
- antagonists
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des composés, des compositions, et des procédés dans le domaine de la chimie médicinale. Les composés et compositions présentement décrits concernent des spiro-oxindoles qui ont une fonction d'antagonistes de l'interaction entre p53 et MDM2, et leur utilisation en tant qu'agents thérapeutiques pour le traitement du cancer et d'autres maladies.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41309410P | 2010-11-12 | 2010-11-12 | |
US201161451958P | 2011-03-11 | 2011-03-11 | |
US201161451968P | 2011-03-11 | 2011-03-11 | |
US201161470992P | 2011-04-01 | 2011-04-01 | |
PCT/US2011/060300 WO2012065022A2 (fr) | 2010-11-12 | 2011-11-11 | Spiro-oxindoles antagonistes de mdm2 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34732B1 true MA34732B1 (fr) | 2013-12-03 |
Family
ID=46048358
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36005A MA34732B1 (fr) | 2010-11-12 | 2013-06-10 | Spiro-oxindoles antagonistes de mdm2 |
Country Status (26)
Country | Link |
---|---|
US (2) | US8680132B2 (fr) |
EP (1) | EP2638046A4 (fr) |
JP (1) | JP2014500870A (fr) |
KR (1) | KR101929188B1 (fr) |
CN (1) | CN103298818B (fr) |
AR (1) | AR083849A1 (fr) |
AU (1) | AU2011326395B2 (fr) |
CA (1) | CA2817585A1 (fr) |
CO (1) | CO6721010A2 (fr) |
CR (1) | CR20130271A (fr) |
DO (1) | DOP2013000104A (fr) |
EA (1) | EA201390682A1 (fr) |
EC (1) | ECSP13012678A (fr) |
GT (1) | GT201300118A (fr) |
IL (1) | IL226275A0 (fr) |
MA (1) | MA34732B1 (fr) |
MX (1) | MX2013005238A (fr) |
NI (1) | NI201300041A (fr) |
NZ (1) | NZ611866A (fr) |
PE (1) | PE20140408A1 (fr) |
SG (1) | SG190230A1 (fr) |
TW (1) | TWI535723B (fr) |
UA (1) | UA109464C2 (fr) |
UY (1) | UY33725A (fr) |
WO (1) | WO2012065022A2 (fr) |
ZA (1) | ZA201304042B (fr) |
Families Citing this family (56)
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CA2682174C (fr) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Polypeptides cousus |
PE20121282A1 (es) * | 2009-11-12 | 2012-10-12 | Univ Michigan | Antagonistas de espiro-oxindol de mdm2 |
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AU2012226890B2 (en) | 2011-03-10 | 2016-10-06 | Daiichi Sankyo Company, Limited | Dispiropyrrolidine derivative |
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WO2014115077A1 (fr) | 2013-01-22 | 2014-07-31 | Novartis Ag | Composés de purinone substitués |
EP3004109A1 (fr) | 2013-05-27 | 2016-04-13 | Novartis AG | Dérivés imidazopyrrolidinone et leur utilisation dans le traitement de maladies |
MX2015016421A (es) | 2013-05-28 | 2016-03-03 | Novartis Ag | Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades. |
US9714249B2 (en) | 2013-05-28 | 2017-07-25 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease |
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AU2015211021B2 (en) | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
AU2015247646B2 (en) | 2014-04-17 | 2019-06-06 | The Regents Of The University Of Michigan | MDM2 inhibitors and therapeutic methods using the same |
TW201613576A (en) * | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
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EP3498712B1 (fr) | 2016-08-08 | 2024-01-03 | Jiangsu Yayo Biotechnology Co. Ltd | Composé de carbonate de polyéthylène glycol d'indolone spirocyclique, composition, procédé de préparation et utilisation de celui-ci |
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WO2009151069A1 (fr) | 2008-06-12 | 2009-12-17 | 第一三共株式会社 | Dérivé d’imidazothiazole ayant une structure cyclique de 4,7-diazaspiro[2.5]octane |
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PE20121282A1 (es) * | 2009-11-12 | 2012-10-12 | Univ Michigan | Antagonistas de espiro-oxindol de mdm2 |
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US20120046306A1 (en) | 2010-08-18 | 2012-02-23 | David Joseph Bartkovitz | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists |
US20120071499A1 (en) | 2010-09-20 | 2012-03-22 | Xin-Jie Chu | Substituted Spiro[3H-Indole-3,6'(5'H)-[1H]Pyrrolo[1,2c]Imidazole-1',2(1H,2'H)-diones |
AU2012253339B2 (en) | 2011-05-11 | 2016-03-31 | Sanofi | Spiro-oxindole MDM2 antagonists |
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2011
- 2011-11-11 NZ NZ61186611A patent/NZ611866A/en not_active IP Right Cessation
- 2011-11-11 TW TW100141225A patent/TWI535723B/zh not_active IP Right Cessation
- 2011-11-11 KR KR1020137015168A patent/KR101929188B1/ko active IP Right Grant
- 2011-11-11 SG SG2013035894A patent/SG190230A1/en unknown
- 2011-11-11 WO PCT/US2011/060300 patent/WO2012065022A2/fr active Application Filing
- 2011-11-11 CA CA2817585A patent/CA2817585A1/fr not_active Abandoned
- 2011-11-11 CN CN201180064853.6A patent/CN103298818B/zh not_active Expired - Fee Related
- 2011-11-11 UY UY0001033725A patent/UY33725A/es not_active Application Discontinuation
- 2011-11-11 EA EA201390682A patent/EA201390682A1/ru unknown
- 2011-11-11 MX MX2013005238A patent/MX2013005238A/es active IP Right Grant
- 2011-11-11 UA UAA201307447A patent/UA109464C2/uk unknown
- 2011-11-11 US US13/294,315 patent/US8680132B2/en not_active Expired - Fee Related
- 2011-11-11 AU AU2011326395A patent/AU2011326395B2/en not_active Ceased
- 2011-11-11 AR ARP110104223A patent/AR083849A1/es unknown
- 2011-11-11 EP EP11840490.4A patent/EP2638046A4/fr not_active Withdrawn
- 2011-11-11 JP JP2013538923A patent/JP2014500870A/ja not_active Ceased
- 2011-11-11 PE PE2013001063A patent/PE20140408A1/es not_active Application Discontinuation
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2013
- 2013-05-09 IL IL226275A patent/IL226275A0/en unknown
- 2013-05-09 GT GT201300118A patent/GT201300118A/es unknown
- 2013-05-09 NI NI201300041A patent/NI201300041A/es unknown
- 2013-05-10 DO DO2013000104A patent/DOP2013000104A/es unknown
- 2013-06-02 EC ECSP13012678 patent/ECSP13012678A/es unknown
- 2013-06-03 ZA ZA2013/04042A patent/ZA201304042B/en unknown
- 2013-06-07 CR CR20130271A patent/CR20130271A/es unknown
- 2013-06-10 MA MA36005A patent/MA34732B1/fr unknown
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2014
- 2014-01-31 US US14/170,101 patent/US9302120B2/en not_active Expired - Fee Related
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