MA35064B1 - Dérivés de thiéno[2,3-d]pyrimidine et leur utilisation pour traiter l'arythmie - Google Patents
Dérivés de thiéno[2,3-d]pyrimidine et leur utilisation pour traiter l'arythmieInfo
- Publication number
- MA35064B1 MA35064B1 MA36364A MA36364A MA35064B1 MA 35064 B1 MA35064 B1 MA 35064B1 MA 36364 A MA36364 A MA 36364A MA 36364 A MA36364 A MA 36364A MA 35064 B1 MA35064 B1 MA 35064B1
- Authority
- MA
- Morocco
- Prior art keywords
- thieno
- pyrimidine derivatives
- treating arrhythmia
- arrhythmia
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés thiénopyrimidine qui sont des inhibiteurs de canaux potassiques. Elle concerne également des compositions pharmaceutiques comprenant les composés et leur utilisation dans le traitement de l'arythmie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1105659.5A GB201105659D0 (en) | 2011-04-01 | 2011-04-01 | Compounds |
PCT/GB2012/050710 WO2012131379A1 (fr) | 2011-04-01 | 2012-03-29 | Dérivés de thiéno[2,3-d]pyrimidine et leur utilisation pour traiter l'arythmie |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35064B1 true MA35064B1 (fr) | 2014-04-03 |
Family
ID=44071904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36364A MA35064B1 (fr) | 2011-04-01 | 2012-03-29 | Dérivés de thiéno[2,3-d]pyrimidine et leur utilisation pour traiter l'arythmie |
Country Status (42)
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014078957A1 (fr) * | 2012-11-20 | 2014-05-30 | The Royal Institution For The Advancement Of Learning/Mcgill University | Inhibiteurs thiénopyrimidine de farnésyl et/ou de géranylgéranyl pyrophosphate synthase |
SG11201804901WA (en) | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
WO2018237084A1 (fr) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Composés interagissant avec la superfamille ras destinés à être utilisés dans le traitement de cancers, de maladies inflammatoires, de rasopathies et de maladies fibrotiques |
Family Cites Families (50)
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CH317906A (de) | 1953-09-16 | 1956-12-15 | Sandoz Ag | Verfahren zur Herstellung von 1-Amino-4-oxyanthrachinonsulfonsäuren |
AU521790B2 (en) | 1977-05-23 | 1982-04-29 | Ici Australia Limited | Process for eradication of ticks |
ZA782648B (en) | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
DD226893A1 (de) | 1981-12-15 | 1985-09-04 | Ralf Boehm | Verfahren zur herstellung von arylaminosubstituierten thieno 2,3-d pyrimidinen |
IL112568A0 (en) | 1994-02-10 | 1995-05-26 | Wyeth John & Brother Ltd | Substituted quinolines, their preparation and pharmaceutical compositions containing them |
IL112569A (en) | 1994-02-10 | 1999-12-22 | Wyeth John & Brother Ltd | Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation |
IL112567A (en) | 1994-02-10 | 2000-02-29 | Wyeth John & Brother Ltd | Substituted quinolines their preparation and pharmaceutical compositions containing them |
IL112566A (en) | 1994-02-10 | 2000-10-31 | Wyeth John & Brother Ltd | Substituted quinolinones and pharmaceutical compositions containing them |
EP0846119B1 (fr) | 1995-08-17 | 2002-11-13 | Takeda Chemical Industries, Ltd. | Derives de thienopyrimidine, leur fabrication et leurs applications comme antagonistes de l'endotheline |
US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
EP0934296B1 (fr) | 1996-07-26 | 2003-06-04 | Nissan Chemical Industries, Limited | Derives de chromane |
US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
RU2116309C1 (ru) | 1997-02-13 | 1998-07-27 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | 4-[(бензо-2,1,3-тиадиазолил-4)амино]-5,6,7,8-тетрагидробензотиено [2,3-d]пиримидин, обладающий противогельминтной активностью при ларвальном альвеолярном эхинококкозе |
US6333337B1 (en) | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
EP1082315A1 (fr) | 1998-06-05 | 2001-03-14 | Icagen, Inc. | Inhibiteurs des canaux de potassium |
AU5444499A (en) | 1998-09-01 | 2000-03-21 | Nissan Chemical Industries Ltd. | Benzoxazine derivatives |
US6194458B1 (en) | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
DE19929076A1 (de) | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
EP1212314B1 (fr) | 1999-09-17 | 2005-11-30 | Nissan Chemical Industries, Ltd. | Derives de benzopyranne |
US6555574B1 (en) | 1999-09-24 | 2003-04-29 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
US6531495B1 (en) | 1999-10-02 | 2003-03-11 | Aventis Pharma Deutschland Gmbh | 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them |
DE19947457A1 (de) | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
EP1218367A1 (fr) | 1999-10-05 | 2002-07-03 | Nissan Chemical Industries, Ltd. | Derive de 4-oxybenzopyranne |
US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
CA2393756A1 (fr) | 1999-12-21 | 2001-06-28 | Aimee D. Reed | Inhibiteurs des canaux potassiques |
CA2421819C (fr) | 2000-09-20 | 2010-03-09 | Merck & Co., Inc. | Isoquinolinone en tant qu'inhibiteurs du canal potassique |
DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10059418A1 (de) | 2000-11-30 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
DE10060807A1 (de) | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
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DE10104802A1 (de) | 2001-02-02 | 2002-08-08 | Merck Patent Gmbh | Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (1) |
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DE10121003A1 (de) | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
DE10128331A1 (de) | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
DE60206505T2 (de) | 2001-06-25 | 2006-07-06 | Nissan Chemical Industries, Ltd. | Substituierte benzopyranderivate gegen arrhytmie |
TW200307539A (en) | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
EP1641803B3 (fr) * | 2003-06-11 | 2010-12-08 | Xention Limited | Utilisation de derives de la thienopyrimidine comme inhibiteurs des canaux potassiques |
GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
ZA200600197B (en) * | 2003-07-02 | 2007-06-27 | Vertex Pharma | Pyrimidines useful as modulators of voltage-gated ion channels |
WO2005066182A1 (fr) | 2004-01-06 | 2005-07-21 | Taisho Pharmaceutical Co., Ltd. | Derives de thienopyrimidine et de thienopyridine substitues par un groupe amino cyclique |
AU2005260077A1 (en) | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
JP5173429B2 (ja) | 2004-12-09 | 2013-04-03 | ゼンション・リミテッド | 化合物 |
US20080108611A1 (en) | 2006-01-19 | 2008-05-08 | Battista Kathleen A | Substituted thienopyrimidine kinase inhibitors |
EP2043654A2 (fr) | 2006-06-12 | 2009-04-08 | Vertex Pharmaceuticals, Inc. | Thiénopyrimidines utiles en tant que modulateurs de canaux ioniques |
DE102009039893B4 (de) | 2009-09-03 | 2012-03-29 | Bundesanstalt für Materialforschung und -Prüfung (BAM) | Verwendung eines Brennstoffs in einem selbstunterhaltenden pulsierenden Sauerstoff-Brennstoff-Verbrennungsprozess |
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2011
- 2011-04-01 GB GBGB1105659.5A patent/GB201105659D0/en not_active Ceased
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2012
- 2012-03-29 HU HUE12718725A patent/HUE028438T2/en unknown
- 2012-03-29 PL PL12718725T patent/PL2694518T3/pl unknown
- 2012-03-29 AP AP2013007198A patent/AP2013007198A0/xx unknown
- 2012-03-29 US US14/008,776 patent/US9249155B2/en not_active Expired - Fee Related
- 2012-03-29 WO PCT/GB2012/050710 patent/WO2012131379A1/fr active Application Filing
- 2012-03-29 AU AU2012235882A patent/AU2012235882B2/en not_active Ceased
- 2012-03-29 CN CN201280016323.9A patent/CN103492392B/zh not_active Expired - Fee Related
- 2012-03-29 ES ES12718725.0T patent/ES2558563T3/es active Active
- 2012-03-29 PT PT127187250T patent/PT2694518E/pt unknown
- 2012-03-29 ME MEP-2015-219A patent/ME02314B/me unknown
- 2012-03-29 RS RS20150833A patent/RS54458B1/en unknown
- 2012-03-29 BR BR112013025236A patent/BR112013025236A2/pt not_active IP Right Cessation
- 2012-03-29 CU CUP2013000124A patent/CU24173B1/es unknown
- 2012-03-29 EP EP12718725.0A patent/EP2694518B1/fr active Active
- 2012-03-29 MX MX2013011301A patent/MX335937B/es unknown
- 2012-03-29 SI SI201230406T patent/SI2694518T1/sl unknown
- 2012-03-29 MA MA36364A patent/MA35064B1/fr unknown
- 2012-03-29 CA CA2831493A patent/CA2831493A1/fr not_active Abandoned
- 2012-03-29 PE PE2013002093A patent/PE20141021A1/es not_active Application Discontinuation
- 2012-03-29 KR KR1020137028742A patent/KR20140023332A/ko not_active Application Discontinuation
- 2012-03-29 UA UAA201312693A patent/UA110131C2/ru unknown
- 2012-03-29 SG SG2013071147A patent/SG193578A1/en unknown
- 2012-03-29 EA EA201301111A patent/EA201301111A1/ru unknown
- 2012-03-29 DK DK12718725.0T patent/DK2694518T3/en active
- 2012-03-29 RU RU2013148627/04A patent/RU2013148627A/ru not_active Application Discontinuation
- 2012-03-29 JP JP2014501722A patent/JP5826374B2/ja not_active Expired - Fee Related
- 2012-03-30 TW TW101111540A patent/TWI516265B/zh not_active IP Right Cessation
- 2012-03-30 AR ARP120101121A patent/AR088735A1/es unknown
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2013
- 2013-09-19 ZA ZA2013/07085A patent/ZA201307085B/en unknown
- 2013-09-24 TN TNP2013000377A patent/TN2013000377A1/fr unknown
- 2013-09-26 CR CR20130488A patent/CR20130488A/es not_active Application Discontinuation
- 2013-09-26 GT GT201300225A patent/GT201300225A/es unknown
- 2013-09-27 CL CL2013002789A patent/CL2013002789A1/es unknown
- 2013-09-29 IL IL228555A patent/IL228555A0/en unknown
- 2013-09-30 NI NI201300100A patent/NI201300100A/es unknown
- 2013-10-23 EC ECSP13012988 patent/ECSP13012988A/es unknown
- 2013-10-24 CO CO13252150A patent/CO6801756A2/es active IP Right Grant
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2014
- 2014-06-30 HK HK14106566.5A patent/HK1193096A1/zh not_active IP Right Cessation
- 2014-07-14 HK HK14107118.6A patent/HK1193806A1/zh not_active IP Right Cessation
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2015
- 2015-12-07 CY CY20151101110T patent/CY1117025T1/el unknown
- 2015-12-08 HR HRP20151340TT patent/HRP20151340T1/hr unknown
- 2015-12-22 SM SM201500322T patent/SMT201500322B/it unknown
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