MA38347A1 - Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak) - Google Patents

Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak)

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Publication number
MA38347A1
MA38347A1 MA38347A MA38347A MA38347A1 MA 38347 A1 MA38347 A1 MA 38347A1 MA 38347 A MA38347 A MA 38347A MA 38347 A MA38347 A MA 38347A MA 38347 A1 MA38347 A1 MA 38347A1
Authority
MA
Morocco
Prior art keywords
jak
pyrrolo
inhibitors
pyrimidine derivatives
janus kinases
Prior art date
Application number
MA38347A
Other languages
English (en)
Inventor
Matthew Frank Brown
Ashley Edward Fenwick
Mark Edward Flanagan
Andrea Gonzales
Timothy Allan Johnson
Neelu Kaila
Mark J Mitton-Fry
Joseph Walter Strohbach
Ruth E Tenbrink
John David Trzupek
Rayomand Jal Unwalla
Michael L Vazquez
D Parikh Mihir
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA38347A1 publication Critical patent/MA38347A1/fr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member

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Abstract

La présente invention concerne des dérivés de pyrrolo[2,3-d]pyrimidine, leur utilisation en tant qu'inhibiteurs de janus kinase (jak), et des compositions pharmaceutiques les contenant.
MA38347A 2013-02-22 2014-02-11 Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak) MA38347A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767947P 2013-02-22 2013-02-22
PCT/IB2014/058889 WO2014128591A1 (fr) 2013-02-22 2014-02-11 Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak)

Publications (1)

Publication Number Publication Date
MA38347A1 true MA38347A1 (fr) 2017-10-31

Family

ID=50151346

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38347A MA38347A1 (fr) 2013-02-22 2014-02-11 Dérivés de pyrrolo[2,3-d]pyrimidine en tant qu'inhibiteurs de janus kinases (jak)

Country Status (47)

Country Link
US (3) US9035074B2 (fr)
EP (2) EP3290421B1 (fr)
JP (2) JP6145179B2 (fr)
KR (1) KR101787858B1 (fr)
CN (2) CN107089985B (fr)
AP (1) AP2015008664A0 (fr)
AR (1) AR094857A1 (fr)
AU (1) AU2014220357B2 (fr)
BR (1) BR112015019634B1 (fr)
CA (1) CA2900703C (fr)
CL (1) CL2015002303A1 (fr)
CR (1) CR20150395A (fr)
CU (1) CU24275B1 (fr)
CY (3) CY1119502T1 (fr)
DK (2) DK3290421T3 (fr)
DO (1) DOP2015000206A (fr)
EA (1) EA027879B1 (fr)
ES (2) ES2647525T3 (fr)
FR (1) FR22C1006I2 (fr)
GE (1) GEP201606600B (fr)
HK (1) HK1213881A1 (fr)
HR (2) HRP20171599T2 (fr)
HU (3) HUE041778T2 (fr)
IL (1) IL240132B (fr)
LT (3) LT2958921T (fr)
MA (1) MA38347A1 (fr)
MD (1) MD4735C1 (fr)
ME (2) ME02904B (fr)
MX (1) MX2015010928A (fr)
MY (1) MY177476A (fr)
NL (1) NL301155I2 (fr)
NO (2) NO3052752T3 (fr)
NZ (1) NZ710411A (fr)
PE (1) PE20151764A1 (fr)
PH (1) PH12015501779B1 (fr)
PL (2) PL2958921T3 (fr)
PT (2) PT2958921T (fr)
RS (2) RS58245B1 (fr)
SG (1) SG11201505816UA (fr)
SI (2) SI2958921T1 (fr)
TN (1) TN2015000355A1 (fr)
TR (1) TR201902525T4 (fr)
TW (1) TWI507408B (fr)
UA (1) UA111804C2 (fr)
UY (1) UY35337A (fr)
WO (1) WO2014128591A1 (fr)
ZA (1) ZA201505454B (fr)

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ES2797376T3 (es) 2013-01-24 2020-12-02 Palvella Therapeutics Inc Composiciones para la administración transdérmica de inhibidores de mTOR
ES2709824T3 (es) 2013-02-22 2019-04-17 Samumed Llc Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina
AP2015008664A0 (en) * 2013-02-22 2015-08-31 Pfizer Pyrrolo [2,3-D] pyrimidine derivatives as inhibitors of janus-related kinases (JAK)
WO2016024185A1 (fr) * 2014-08-12 2016-02-18 Pfizer Inc. Dérivés de pyrrolo[2,3-d]pyrimidine utiles pour inhiber la janus kinase
RU2727039C2 (ru) 2014-08-20 2020-07-17 СЭМЬЮМЕД, ЭлЭлСи Гамма-дикетоны для лечения и профилактики старения кожи и морщин
EA036063B1 (ru) * 2015-05-29 2020-09-22 Уси Форчун Фармасьютикал Ко., Лтд Ингибитор янус-киназы
US11773106B2 (en) 2015-10-16 2023-10-03 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
AU2016340167B2 (en) 2015-10-16 2021-06-24 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
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WO2017143014A1 (fr) * 2016-02-16 2017-08-24 Brian Kim Inhibiteurs de jak et leurs utilisations
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CN108794480A (zh) * 2017-04-28 2018-11-13 天津药物研究院有限公司 吡咯并嘧啶类化合物、其制备方法和用途
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US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
JP2021530463A (ja) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物および使用方法
US10815240B2 (en) 2018-07-06 2020-10-27 Pfizer Inc. Manufacturing process and intermediates for a pyrrolo[2,3-d]pyrimidine compound and use thereof
US10744136B2 (en) 2018-11-05 2020-08-18 Avista Pharma Solutions, Inc. Sulfonamide derivatives as JAK inhibitors
PL3915989T3 (pl) * 2019-01-30 2023-12-11 Felicamed Biotechnology Co., Ltd Inhibitor jak i sposób jego otrzymywania
CN113646310A (zh) 2019-02-15 2021-11-12 辉瑞公司 结晶性的嘧啶基-3,8-二氮杂双环[3.2.1]辛烷基甲酮化合物及其用途
WO2020182159A1 (fr) 2019-03-14 2020-09-17 上海华汇拓医药科技有限公司 Inhibiteur de kinase jak, son procédé de préparation et ses applications dans le domaine de la médecine
WO2020261041A1 (fr) * 2019-06-27 2020-12-30 Glenmark Life Sciences Limited Procédé pour la préparation d'abrocitinib
CN114667148A (zh) * 2019-09-11 2022-06-24 辉瑞公司 用jak抑制剂治疗汗腺炎
AU2021248720A1 (en) 2020-04-04 2022-11-03 Pfizer Inc. Methods of treating coronavirus disease 2019
CN113637018A (zh) 2020-04-27 2021-11-12 苏州晶云药物科技股份有限公司 磺酰胺类化合物的晶型及其制备方法
EP4157845A1 (fr) * 2020-05-28 2023-04-05 Pfizer Inc. Dérivés de pyrrolo [2,3-d] pyrimidine
CN116917285A (zh) * 2020-09-11 2023-10-20 高德美控股有限公司 新型jak抑制剂化合物、其合成方法及其用途
CN116847850A (zh) 2021-02-02 2023-10-03 辉瑞公司 治疗慢性手部湿疹的给药方案
KR20230019801A (ko) * 2021-08-02 2023-02-09 한국화학연구원 신규한 피롤로 피리미딘 유도체 화합물, 이의 제조방법, 및 이를 유효성분으로 포함하는 대사성 간질환의 예방 또는 치료용 약학적 조성물
CN118255769A (zh) * 2022-12-28 2024-06-28 格格巫（珠海）生物科技有限公司 一种立体异构体的制备方法及中间体

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