LT2958921T - Pirolo[2, 3 -d]pirimidino dariniai, kaip janus kinazės (jak) inhibitoriai - Google Patents

Pirolo[2, 3 -d]pirimidino dariniai, kaip janus kinazės (jak) inhibitoriai

Info

Publication number
LT2958921T
LT2958921T LTEP14705887.9T LT14705887T LT2958921T LT 2958921 T LT2958921 T LT 2958921T LT 14705887 T LT14705887 T LT 14705887T LT 2958921 T LT2958921 T LT 2958921T
Authority
LT
Lithuania
Prior art keywords
jak
pyrrolo
inhibitors
pyrimidine derivatives
janus kinases
Prior art date
Application number
LTEP14705887.9T
Other languages
English (en)
Inventor
Matthew Frank Brown
Ashley Edward Fenwick
Mark Edward Flanagan
Andrea GONZALES
Timothy Allan JOHNSON
Neelu Kaila
Mark J. Mitton-Fry
Joseph Walter Strohbach
Ruth E. Tenbrink
John David TRZUPEK
Rayomand Jal Unwalla
Michael L. Vazquez
Mihir D. PARIKH
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of LT2958921T publication Critical patent/LT2958921T/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
LTEP14705887.9T 2013-02-22 2014-02-11 Pirolo[2, 3 -d]pirimidino dariniai, kaip janus kinazės (jak) inhibitoriai LT2958921T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767947P 2013-02-22 2013-02-22
PCT/IB2014/058889 WO2014128591A1 (en) 2013-02-22 2014-02-11 Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak)

Publications (1)

Publication Number Publication Date
LT2958921T true LT2958921T (lt) 2017-11-27

Family

ID=50151346

Family Applications (3)

Application Number Title Priority Date Filing Date
LTEP17191163.9T LT3290421T (lt) 2013-02-22 2014-02-11 Pirolo [2, 3 -d]pirimidino darinių derinys su vienu arba daugiau papildomų agentų, kaip janus kinazės (jak) inhibitorių
LTEP14705887.9T LT2958921T (lt) 2013-02-22 2014-02-11 Pirolo[2, 3 -d]pirimidino dariniai, kaip janus kinazės (jak) inhibitoriai
LTPA2022502C LTPA2022502I1 (lt) 2013-02-22 2022-01-26

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP17191163.9T LT3290421T (lt) 2013-02-22 2014-02-11 Pirolo [2, 3 -d]pirimidino darinių derinys su vienu arba daugiau papildomų agentų, kaip janus kinazės (jak) inhibitorių

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTPA2022502C LTPA2022502I1 (lt) 2013-02-22 2022-01-26

Country Status (47)

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US (3) US9035074B2 (lt)
EP (2) EP2958921B1 (lt)
JP (2) JP6145179B2 (lt)
KR (1) KR101787858B1 (lt)
CN (2) CN105008362B (lt)
AP (1) AP2015008664A0 (lt)
AR (1) AR094857A1 (lt)
AU (1) AU2014220357B2 (lt)
BR (1) BR112015019634B1 (lt)
CA (1) CA2900703C (lt)
CL (1) CL2015002303A1 (lt)
CR (1) CR20150395A (lt)
CU (1) CU24275B1 (lt)
CY (2) CY1119502T1 (lt)
DK (2) DK3290421T3 (lt)
DO (1) DOP2015000206A (lt)
EA (1) EA027879B1 (lt)
ES (2) ES2647525T3 (lt)
FR (1) FR22C1006I2 (lt)
GE (1) GEP201606600B (lt)
HK (1) HK1213881A1 (lt)
HR (2) HRP20171599T2 (lt)
HU (3) HUE041778T2 (lt)
IL (1) IL240132B (lt)
LT (3) LT3290421T (lt)
MA (1) MA38347A1 (lt)
MD (1) MD4735C1 (lt)
ME (2) ME02904B (lt)
MX (1) MX2015010928A (lt)
MY (1) MY177476A (lt)
NL (1) NL301155I2 (lt)
NO (1) NO3052752T3 (lt)
NZ (1) NZ710411A (lt)
PE (1) PE20151764A1 (lt)
PH (1) PH12015501779B1 (lt)
PL (2) PL2958921T3 (lt)
PT (2) PT2958921T (lt)
RS (2) RS58245B1 (lt)
SG (1) SG11201505816UA (lt)
SI (2) SI3290421T1 (lt)
TN (1) TN2015000355A1 (lt)
TR (1) TR201902525T4 (lt)
TW (1) TWI507408B (lt)
UA (1) UA111804C2 (lt)
UY (1) UY35337A (lt)
WO (1) WO2014128591A1 (lt)
ZA (1) ZA201505454B (lt)

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CN114667148A (zh) * 2019-09-11 2022-06-24 辉瑞公司 用jak抑制剂治疗汗腺炎
CN115715194A (zh) 2020-04-04 2023-02-24 辉瑞公司 治疗冠状病毒疾病2019的方法
CN113637018A (zh) 2020-04-27 2021-11-12 苏州晶云药物科技股份有限公司 磺酰胺类化合物的晶型及其制备方法
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