MD4735B1 - Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK) - Google Patents

Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK)

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Publication number
MD4735B1
MD4735B1 MDA20150073A MD20150073A MD4735B1 MD 4735 B1 MD4735 B1 MD 4735B1 MD A20150073 A MDA20150073 A MD A20150073A MD 20150073 A MD20150073 A MD 20150073A MD 4735 B1 MD4735 B1 MD 4735B1
Authority
MD
Moldova
Prior art keywords
pyrimidine derivatives
jak
pyrrolo
inhibitors
janus
Prior art date
Application number
MDA20150073A
Other languages
English (en)
Russian (ru)
Other versions
MD20150073A2 (ro
MD4735C1 (ro
Inventor
Мэттью Фрэнк Браун
Эшли Эдвард ФЕНВИК
Марк Эдвард Флэнаган
Андреа Гонсалес
Тимоти Аллан Джонсон
Неелу КАЙЛА
Марк Дж. Миттон-Фрай
Джозеф Уолтер Стробах
Рут Е. Тенбринк
Джон Дэвид Тшупек
Райоманд Джал Унвалла
Майкл Л. Васкес
Михир Д. Парих
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20150073A2 publication Critical patent/MD20150073A2/ro
Publication of MD4735B1 publication Critical patent/MD4735B1/ro
Publication of MD4735C1 publication Critical patent/MD4735C1/ro

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

Invenţia se referă la derivaţi ai pirolo[2,3-d]pirimidinei farmaceutic activi. Conform invenţiei, se revendică derivaţi ai pirolo[2,3-d]pirimidinei cu formula IA: De asemenea, se revendică utilizarea lor în calitate de inhibitori de Kinaze Janus (JAK) şi compoziţii farmaceutice care îi conţin.
MDA20150073A 2013-02-22 2014-02-11 Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK) MD4735C1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767947P 2013-02-22 2013-02-22
PCT/IB2014/058889 WO2014128591A1 (en) 2013-02-22 2014-02-11 Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak)

Publications (3)

Publication Number Publication Date
MD20150073A2 MD20150073A2 (ro) 2016-01-31
MD4735B1 true MD4735B1 (ro) 2020-12-31
MD4735C1 MD4735C1 (ro) 2021-07-31

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MDA20150073A MD4735C1 (ro) 2013-02-22 2014-02-11 Derivaţi ai pirolo[2,3-d]pirimidinei ca inhibitori de Kinaze Janus-asociate (JAK)

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US (3) US9035074B2 (ro)
EP (2) EP3290421B1 (ro)
JP (2) JP6145179B2 (ro)
KR (1) KR101787858B1 (ro)
CN (2) CN107089985B (ro)
AP (1) AP2015008664A0 (ro)
AR (1) AR094857A1 (ro)
AU (1) AU2014220357B2 (ro)
BR (1) BR112015019634B1 (ro)
CA (1) CA2900703C (ro)
CL (1) CL2015002303A1 (ro)
CR (1) CR20150395A (ro)
CU (1) CU24275B1 (ro)
CY (3) CY1119502T1 (ro)
DK (2) DK3290421T3 (ro)
DO (1) DOP2015000206A (ro)
EA (1) EA027879B1 (ro)
ES (2) ES2713052T3 (ro)
FR (1) FR22C1006I2 (ro)
GE (1) GEP201606600B (ro)
HK (1) HK1213881A1 (ro)
HR (2) HRP20171599T2 (ro)
HU (3) HUE041778T2 (ro)
IL (1) IL240132B (ro)
LT (3) LT2958921T (ro)
MA (1) MA38347A1 (ro)
MD (1) MD4735C1 (ro)
ME (2) ME02904B (ro)
MX (1) MX2015010928A (ro)
MY (1) MY177476A (ro)
NL (1) NL301155I2 (ro)
NO (1) NO3052752T3 (ro)
NZ (1) NZ710411A (ro)
PE (1) PE20151764A1 (ro)
PH (1) PH12015501779A1 (ro)
PL (2) PL3290421T3 (ro)
PT (2) PT2958921T (ro)
RS (2) RS56503B1 (ro)
SG (1) SG11201505816UA (ro)
SI (2) SI3290421T1 (ro)
TN (1) TN2015000355A1 (ro)
TR (1) TR201902525T4 (ro)
TW (1) TWI507408B (ro)
UA (1) UA111804C2 (ro)
UY (1) UY35337A (ro)
WO (1) WO2014128591A1 (ro)
ZA (1) ZA201505454B (ro)

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JP7096592B2 (ja) 2016-02-16 2022-07-06 ワシントン・ユニバーシティ Ｊａｋ阻害剤およびこれらの利用
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KR20230125813A (ko) 2021-02-02 2023-08-29 화이자 인코포레이티드 만성 손 습진의 치료를 위한 투여 요법
WO2023014049A1 (ko) * 2021-08-02 2023-02-09 한국화학연구원 신규한 피롤로 피리미딘 유도체 화합물, 이의 제조방법, 및 이를 유효성분으로 포함하는 대사성 간질환의 예방 또는 치료용 약학적 조성물
CN118255769A (zh) * 2022-12-28 2024-06-28 格格巫（珠海）生物科技有限公司 一种立体异构体的制备方法及中间体

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