HRP20190152T1 - Kombinacija pirolo[2,3-d]pirimidinskih derivata s jednim ili više dodatnih sredstava kao inhibitori kinaza srodnih janus kinazi (jak) - Google Patents

Kombinacija pirolo[2,3-d]pirimidinskih derivata s jednim ili više dodatnih sredstava kao inhibitori kinaza srodnih janus kinazi (jak)

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Publication number
HRP20190152T1
HRP20190152T1 HRP20190152TT HRP20190152T HRP20190152T1 HR P20190152 T1 HRP20190152 T1 HR P20190152T1 HR P20190152T T HRP20190152T T HR P20190152TT HR P20190152 T HRP20190152 T HR P20190152T HR P20190152 T1 HRP20190152 T1 HR P20190152T1
Authority
HR
Croatia
Prior art keywords
janus
jak
pyrrolo
inhibitors
combination
Prior art date
Application number
HRP20190152TT
Other languages
English (en)
Inventor
Matthew Frank Brown
Ashley Edward Fenwick
Mark Edward Flanagan
Andrea GONZALES
Timothy Allan JOHNSON
Neelu Kaila
Mark Joseph Mitton-Fry
Joseph Walter Strohbach
Ruth E. Tenbrink
John David TRZUPEK
Rayomand Jal Unwalla
Michael L. Vazquez
Mihir D. Parikh
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HRP20190152T1 publication Critical patent/HRP20190152T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member

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  • Ophthalmology & Optometry (AREA)
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HRP20190152TT 2013-02-22 2019-01-23 Kombinacija pirolo[2,3-d]pirimidinskih derivata s jednim ili više dodatnih sredstava kao inhibitori kinaza srodnih janus kinazi (jak) HRP20190152T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767947P 2013-02-22 2013-02-22
EP17191163.9A EP3290421B1 (en) 2013-02-22 2014-02-11 Combination of pyrrolo [2, 3 -d]pyrimidine derivatives with one or more additional agents as inhibitors of janus- related kinases (jak)

Publications (1)

Publication Number Publication Date
HRP20190152T1 true HRP20190152T1 (hr) 2019-03-22

Family

ID=50151346

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20171599TT HRP20171599T2 (hr) 2013-02-22 2017-10-19 DERIVATI PIROLO[2,3-d]PIRIMIDINA KAO INHIBITORI JANUS KINAZA (JAK)
HRP20190152TT HRP20190152T1 (hr) 2013-02-22 2019-01-23 Kombinacija pirolo[2,3-d]pirimidinskih derivata s jednim ili više dodatnih sredstava kao inhibitori kinaza srodnih janus kinazi (jak)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20171599TT HRP20171599T2 (hr) 2013-02-22 2017-10-19 DERIVATI PIROLO[2,3-d]PIRIMIDINA KAO INHIBITORI JANUS KINAZA (JAK)

Country Status (47)

Country Link
US (3) US9035074B2 (hr)
EP (2) EP2958921B1 (hr)
JP (2) JP6145179B2 (hr)
KR (1) KR101787858B1 (hr)
CN (2) CN105008362B (hr)
AP (1) AP2015008664A0 (hr)
AR (1) AR094857A1 (hr)
AU (1) AU2014220357B2 (hr)
BR (1) BR112015019634B1 (hr)
CA (1) CA2900703C (hr)
CL (1) CL2015002303A1 (hr)
CR (1) CR20150395A (hr)
CU (1) CU24275B1 (hr)
CY (3) CY1119502T1 (hr)
DK (2) DK2958921T3 (hr)
DO (1) DOP2015000206A (hr)
EA (1) EA027879B1 (hr)
ES (2) ES2647525T3 (hr)
FR (1) FR22C1006I2 (hr)
GE (1) GEP201606600B (hr)
HK (1) HK1213881A1 (hr)
HR (2) HRP20171599T2 (hr)
HU (3) HUE041778T2 (hr)
IL (1) IL240132B (hr)
LT (3) LT2958921T (hr)
MA (1) MA38347A1 (hr)
MD (1) MD4735C1 (hr)
ME (2) ME03301B (hr)
MX (1) MX2015010928A (hr)
MY (1) MY177476A (hr)
NL (1) NL301155I2 (hr)
NO (2) NO3052752T3 (hr)
NZ (1) NZ710411A (hr)
PE (1) PE20151764A1 (hr)
PH (1) PH12015501779B1 (hr)
PL (2) PL2958921T3 (hr)
PT (2) PT2958921T (hr)
RS (2) RS58245B1 (hr)
SG (1) SG11201505816UA (hr)
SI (2) SI3290421T1 (hr)
TN (1) TN2015000355A1 (hr)
TR (1) TR201902525T4 (hr)
TW (1) TWI507408B (hr)
UA (1) UA111804C2 (hr)
UY (1) UY35337A (hr)
WO (1) WO2014128591A1 (hr)
ZA (1) ZA201505454B (hr)

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