MX2021009761A - Compuesto de pirimidinil-3,8-diazabiciclo [3.2.1]octanilmetanona cristalina y uso de este. - Google Patents

Compuesto de pirimidinil-3,8-diazabiciclo [3.2.1]octanilmetanona cristalina y uso de este.

Info

Publication number
MX2021009761A
MX2021009761A MX2021009761A MX2021009761A MX2021009761A MX 2021009761 A MX2021009761 A MX 2021009761A MX 2021009761 A MX2021009761 A MX 2021009761A MX 2021009761 A MX2021009761 A MX 2021009761A MX 2021009761 A MX2021009761 A MX 2021009761A
Authority
MX
Mexico
Prior art keywords
diazabicyclo
octanylmethanone
pyrimidinyl
crystalline
compound
Prior art date
Application number
MX2021009761A
Other languages
English (en)
Inventor
Xiaojing Yang
Amanda Patrice Surajhie Samuel
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2021009761A publication Critical patent/MX2021009761A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención divulga una forma cristalina novedosa de ((S)-2,2- difluorociclopropil)-((1R,5S)-3-(2-((1-metil-1H-pirazol- 4-il)amino)pirimidin-4-il)-3,8- diazabiciclo[3.2.1]octan-8-il)meta nona base libre, una composición farmacéutica que la contiene, preparaciones de esta y sus usos.
MX2021009761A 2019-02-15 2020-02-12 Compuesto de pirimidinil-3,8-diazabiciclo [3.2.1]octanilmetanona cristalina y uso de este. MX2021009761A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962806180P 2019-02-15 2019-02-15
PCT/IB2020/051128 WO2020165788A1 (en) 2019-02-15 2020-02-12 Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof

Publications (1)

Publication Number Publication Date
MX2021009761A true MX2021009761A (es) 2021-12-15

Family

ID=69726639

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021009761A MX2021009761A (es) 2019-02-15 2020-02-12 Compuesto de pirimidinil-3,8-diazabiciclo [3.2.1]octanilmetanona cristalina y uso de este.

Country Status (13)

Country Link
US (1) US20220144846A1 (es)
EP (1) EP3924355A1 (es)
JP (1) JP2020138960A (es)
KR (1) KR20210114470A (es)
CN (1) CN113646310A (es)
AR (1) AR118099A1 (es)
AU (1) AU2020222083B2 (es)
BR (1) BR112021015951A2 (es)
CA (1) CA3130034C (es)
MX (1) MX2021009761A (es)
SG (1) SG11202108863WA (es)
TW (1) TWI820301B (es)
WO (1) WO2020165788A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021249367A1 (zh) * 2020-06-09 2021-12-16 苏州晶云药物科技股份有限公司 二氮杂双环类化合物的对甲苯磺酸盐新晶型及其制备方法
CN114835717A (zh) * 2021-02-01 2022-08-02 杭州领业医药科技有限公司 Brepocitinib甲苯磺酸盐的晶型及其制备方法和用途
CN113461687B (zh) * 2021-08-10 2022-04-19 四川大学华西医院 2,8-氮杂-[4,5]十螺环酮衍生物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
DK2958921T3 (da) 2013-02-22 2017-11-06 Pfizer Pyrrolo[2,3-D]pyrimidin-derivater som hæmmere af Janus kinaser (JAK)
NO2721710T3 (es) * 2014-08-21 2018-03-31

Also Published As

Publication number Publication date
EP3924355A1 (en) 2021-12-22
JP2020138960A (ja) 2020-09-03
AR118099A1 (es) 2021-09-15
AU2020222083B2 (en) 2022-11-17
TW202045511A (zh) 2020-12-16
SG11202108863WA (en) 2021-09-29
CA3130034A1 (en) 2020-08-20
CN113646310A (zh) 2021-11-12
CA3130034C (en) 2023-12-19
BR112021015951A2 (pt) 2021-10-05
US20220144846A1 (en) 2022-05-12
TWI820301B (zh) 2023-11-01
WO2020165788A1 (en) 2020-08-20
KR20210114470A (ko) 2021-09-23
AU2020222083A1 (en) 2021-09-02

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