JO3794B1 - المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون - Google Patents
المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتونInfo
- Publication number
- JO3794B1 JO3794B1 JOP/2016/0256A JOP20160256A JO3794B1 JO 3794 B1 JO3794 B1 JO 3794B1 JO P20160256 A JOP20160256 A JO P20160256A JO 3794 B1 JO3794 B1 JO 3794B1
- Authority
- JO
- Jordan
- Prior art keywords
- bruton
- inhibitors
- tyrosine kinase
- polycyclic compounds
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
الاختراع الحالي موجه لمركبات الصيغة (I) وأساليب استخدامها وتحضيرها، فضلاً عن التركيبات التي تتكون منها مركبات الصيغة (I). (I)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562265836P | 2015-12-10 | 2015-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3794B1 true JO3794B1 (ar) | 2021-01-31 |
Family
ID=57681784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2016/0256A JO3794B1 (ar) | 2015-12-10 | 2016-12-08 | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US10717745B2 (ar) |
| EP (2) | EP3386991B1 (ar) |
| JP (2) | JP6835846B2 (ar) |
| KR (1) | KR102103395B1 (ar) |
| CN (2) | CN113121562B (ar) |
| AR (1) | AR107042A1 (ar) |
| AU (1) | AU2016366541B2 (ar) |
| BR (1) | BR112018011526B1 (ar) |
| CA (1) | CA3007990C (ar) |
| CY (1) | CY1123263T1 (ar) |
| DK (1) | DK3386991T3 (ar) |
| EA (1) | EA035168B1 (ar) |
| ES (1) | ES2805835T3 (ar) |
| HR (1) | HRP20201193T1 (ar) |
| HU (1) | HUE049502T2 (ar) |
| IL (1) | IL259863B (ar) |
| JO (1) | JO3794B1 (ar) |
| LT (1) | LT3386991T (ar) |
| MA (2) | MA43409B1 (ar) |
| MD (1) | MD3386991T2 (ar) |
| ME (1) | ME03803B (ar) |
| MX (1) | MX2018007075A (ar) |
| PL (1) | PL3386991T3 (ar) |
| PT (1) | PT3386991T (ar) |
| RS (1) | RS60604B1 (ar) |
| SI (1) | SI3386991T1 (ar) |
| TW (1) | TWI729047B (ar) |
| UY (1) | UY37015A (ar) |
| WO (1) | WO2017100662A1 (ar) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3794B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
| JO3793B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | مثبطات تيروزين كاينيز بروتون وأساليب استخدامها |
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| WO2018170220A1 (en) * | 2017-03-15 | 2018-09-20 | Janssen Sciences Ireland Uc | Methods of selective aryl- and heteroaryl-nitrogen bond formation |
| CN108164397B (zh) * | 2018-01-18 | 2020-11-13 | 暨南大学 | 一类邻苯二酚衍生物及其制备方法 |
| AU2019284472B2 (en) | 2018-06-11 | 2024-05-30 | Amgen Inc. | KRAS G12C inhibitors for treating cancer |
| CN114945576B (zh) * | 2020-01-07 | 2023-10-13 | 南京明德新药研发有限公司 | 氘代噻吩并吡啶类化合物 |
| KR20230154232A (ko) | 2021-03-03 | 2023-11-07 | 얀센 파마슈티카 엔브이 | Malt1 억제제 및 btk 억제제를 사용하는 병용 치료 |
| MX2023014435A (es) | 2021-06-04 | 2024-03-08 | Janssen Pharmaceutica Nv | Inhibidores de la tirosina quinasa de bruton y métodos de su uso. |
| MX2023015147A (es) | 2021-06-30 | 2024-04-01 | Janssen Pharmaceutica Nv | Inhibidores de la tirosina quinasa de bruton y métodos de su uso. |
| MX2024001840A (es) | 2021-08-09 | 2024-02-28 | Janssen Pharmaceutica Nv | Composiciones para usar en el tratamiento de neoplasias de celulas b. |
| WO2023156599A1 (en) * | 2022-02-18 | 2023-08-24 | Janssen Pharmaceutica Nv | Synthesis of bruton's tyrosine kinase inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3112415A1 (de) | 1981-03-28 | 1982-10-07 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur chlorierung von cyclischen amiden und cyclischen vinylogen amiden |
| US5430150A (en) | 1992-12-16 | 1995-07-04 | American Cyanamid Company | Retroviral protease inhibitors |
| US5300478A (en) | 1993-01-28 | 1994-04-05 | Zeneca Limited | Substituted fused pyrazolo compounds |
| JP2008513463A (ja) | 2004-09-15 | 2008-05-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | チアゾロピリジンキナーゼ阻害剤 |
| WO2006118749A1 (en) * | 2005-05-04 | 2006-11-09 | Janssen Pharmaceutica, N.V. | Thia-tetraazaacenaphthylene kinase inhibitors |
| WO2007019191A2 (en) | 2005-08-08 | 2007-02-15 | Janssen Pharmaceutica, N.V. | Thiazolopyrimidine kinase inhibitors |
| WO2007092879A2 (en) | 2006-02-08 | 2007-08-16 | Janssen Pharmaceutica, N.V. | Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors |
| EP2201840B1 (en) | 2006-09-22 | 2011-11-02 | Pharmacyclics, Inc. | Inhibitors of Bruton's Tyrosine Kinase |
| EP2365970B1 (en) * | 2008-11-12 | 2018-03-21 | Gilead Connecticut, Inc. | Pyridazinones and their use as btk inhibitors |
| WO2011024869A1 (ja) * | 2009-08-26 | 2011-03-03 | 武田薬品工業株式会社 | 縮合複素環誘導体およびその用途 |
| WO2011133609A2 (en) | 2010-04-19 | 2011-10-27 | The Translational Genomics Research Institute | Methods and kits to predict therapeutic outcome of btk inhibitors |
| US20140249105A1 (en) | 2011-07-25 | 2014-09-04 | Diverchim | Novel ceramide analogues, processes for preparing same and uses thereof |
| PE20151652A1 (es) | 2013-03-15 | 2015-11-12 | Janssen Pharmaceutica Nv | Proceso e intermedios para preparar un medicamento |
| CN108947913A (zh) * | 2013-12-11 | 2018-12-07 | 比奥根Ma公司 | 可用于治疗人类肿瘤学、神经病学和免疫学疾病的联芳基化合物 |
| JO3793B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | مثبطات تيروزين كاينيز بروتون وأساليب استخدامها |
| JO3794B1 (ar) | 2015-12-10 | 2021-01-31 | Janssen Pharmaceutica Nv | المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون |
| WO2018103060A1 (en) | 2016-12-09 | 2018-06-14 | Janssen Pharmaceutica Nv | Inhibitors of bruton's tyrosine kinase and methods of their use |
| WO2018103058A1 (en) | 2016-12-09 | 2018-06-14 | Janssen Pharmaceutica Nv | Inhibitors of bruton's tyrosine kinase and methods of their use |
-
2016
- 2016-12-08 JO JOP/2016/0256A patent/JO3794B1/ar active
- 2016-12-09 MD MDE20180978T patent/MD3386991T2/ro unknown
- 2016-12-09 EA EA201891378A patent/EA035168B1/ru unknown
- 2016-12-09 AU AU2016366541A patent/AU2016366541B2/en active Active
- 2016-12-09 TW TW105140760A patent/TWI729047B/zh active
- 2016-12-09 MX MX2018007075A patent/MX2018007075A/es unknown
- 2016-12-09 PT PT168201069T patent/PT3386991T/pt unknown
- 2016-12-09 CN CN202110404024.3A patent/CN113121562B/zh active Active
- 2016-12-09 MA MA43409A patent/MA43409B1/fr unknown
- 2016-12-09 ME MEP-2020-155A patent/ME03803B/me unknown
- 2016-12-09 EP EP16820106.9A patent/EP3386991B1/en active Active
- 2016-12-09 PL PL16820106T patent/PL3386991T3/pl unknown
- 2016-12-09 EP EP20177012.0A patent/EP3719022A1/en active Pending
- 2016-12-09 CN CN201680072125.2A patent/CN108884106A/zh active Pending
- 2016-12-09 DK DK16820106.9T patent/DK3386991T3/da active
- 2016-12-09 LT LTEP16820106.9T patent/LT3386991T/lt unknown
- 2016-12-09 HU HUE16820106A patent/HUE049502T2/hu unknown
- 2016-12-09 RS RS20200884A patent/RS60604B1/sr unknown
- 2016-12-09 SI SI201630825T patent/SI3386991T1/sl unknown
- 2016-12-09 UY UY0001037015A patent/UY37015A/es active IP Right Grant
- 2016-12-09 ES ES16820106T patent/ES2805835T3/es active Active
- 2016-12-09 KR KR1020187018900A patent/KR102103395B1/ko active IP Right Grant
- 2016-12-09 BR BR112018011526-6A patent/BR112018011526B1/pt active IP Right Grant
- 2016-12-09 MA MA053110A patent/MA53110A/fr unknown
- 2016-12-09 US US15/374,905 patent/US10717745B2/en active Active
- 2016-12-09 JP JP2018530000A patent/JP6835846B2/ja active Active
- 2016-12-09 CA CA3007990A patent/CA3007990C/en active Active
- 2016-12-09 WO PCT/US2016/065954 patent/WO2017100662A1/en active Application Filing
- 2016-12-12 AR ARP160103789A patent/AR107042A1/es unknown
-
2018
- 2018-06-07 IL IL259863A patent/IL259863B/en active IP Right Grant
-
2019
- 2019-05-15 US US16/413,453 patent/US10934310B2/en active Active
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2020
- 2020-05-13 US US15/931,437 patent/US11319329B2/en active Active
- 2020-07-30 HR HRP20201193TT patent/HRP20201193T1/hr unknown
- 2020-08-18 CY CY20201100769T patent/CY1123263T1/el unknown
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2021
- 2021-02-04 JP JP2021016602A patent/JP7072690B2/ja active Active
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2022
- 2022-03-25 US US17/705,225 patent/US12065446B2/en active Active
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