HK1193096A1 - 噻吩並 嘧啶衍生物及其用於治療心律失常的用途 - Google Patents

噻吩並 嘧啶衍生物及其用於治療心律失常的用途

Info

Publication number
HK1193096A1
HK1193096A1 HK14106566.5A HK14106566A HK1193096A1 HK 1193096 A1 HK1193096 A1 HK 1193096A1 HK 14106566 A HK14106566 A HK 14106566A HK 1193096 A1 HK1193096 A1 HK 1193096A1
Authority
HK
Hong Kong
Prior art keywords
thieno
pyrimidine derivatives
treat arrhythmia
arrhythmia
treat
Prior art date
Application number
HK14106566.5A
Other languages
English (en)
Inventor
Derek Edward John
John Ford
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44071904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1193096(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xention Ltd filed Critical Xention Ltd
Publication of HK1193096A1 publication Critical patent/HK1193096A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK14106566.5A 2011-04-01 2014-06-30 噻吩並 嘧啶衍生物及其用於治療心律失常的用途 HK1193096A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1105659.5A GB201105659D0 (en) 2011-04-01 2011-04-01 Compounds
PCT/GB2012/050710 WO2012131379A1 (en) 2011-04-01 2012-03-29 Thieno [2, 3 -d] pyrimidine derivatives and their use to treat arrhythmia

Publications (1)

Publication Number Publication Date
HK1193096A1 true HK1193096A1 (zh) 2014-09-12

Family

ID=44071904

Family Applications (2)

Application Number Title Priority Date Filing Date
HK14106566.5A HK1193096A1 (zh) 2011-04-01 2014-06-30 噻吩並 嘧啶衍生物及其用於治療心律失常的用途
HK14107118.6A HK1193806A1 (zh) 2011-04-01 2014-07-14 噻吩並 嘧啶衍生物及其用於治療心律失常的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK14107118.6A HK1193806A1 (zh) 2011-04-01 2014-07-14 噻吩並 嘧啶衍生物及其用於治療心律失常的用途

Country Status (42)

Country Link
US (1) US9249155B2 (zh)
EP (1) EP2694518B1 (zh)
JP (1) JP5826374B2 (zh)
KR (1) KR20140023332A (zh)
CN (1) CN103492392B (zh)
AP (1) AP2013007198A0 (zh)
AR (1) AR088735A1 (zh)
AU (1) AU2012235882B2 (zh)
BR (1) BR112013025236A2 (zh)
CA (1) CA2831493A1 (zh)
CL (1) CL2013002789A1 (zh)
CO (1) CO6801756A2 (zh)
CR (1) CR20130488A (zh)
CU (1) CU24173B1 (zh)
CY (1) CY1117025T1 (zh)
DK (1) DK2694518T3 (zh)
EA (1) EA201301111A1 (zh)
EC (1) ECSP13012988A (zh)
ES (1) ES2558563T3 (zh)
GB (1) GB201105659D0 (zh)
GT (1) GT201300225A (zh)
HK (2) HK1193096A1 (zh)
HR (1) HRP20151340T1 (zh)
HU (1) HUE028438T2 (zh)
IL (1) IL228555A0 (zh)
MA (1) MA35064B1 (zh)
ME (1) ME02314B (zh)
MX (1) MX335937B (zh)
NI (1) NI201300100A (zh)
PE (1) PE20141021A1 (zh)
PL (1) PL2694518T3 (zh)
PT (1) PT2694518E (zh)
RS (1) RS54458B1 (zh)
RU (1) RU2013148627A (zh)
SG (1) SG193578A1 (zh)
SI (1) SI2694518T1 (zh)
SM (1) SMT201500322B (zh)
TN (1) TN2013000377A1 (zh)
TW (1) TWI516265B (zh)
UA (1) UA110131C2 (zh)
WO (1) WO2012131379A1 (zh)
ZA (1) ZA201307085B (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150307532A1 (en) * 2012-11-20 2015-10-29 The Royal Institution For The Advancement Of Learning/Mcgill University Thienopyrimidine inhibitors of farnesyl and/or geranylgeranyl pyrophosphate synthase
JP7114076B2 (ja) 2015-12-22 2022-08-08 シャイ・セラピューティクス・エルエルシー がん及び炎症性疾患の処置のための化合物
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物
MX2019014875A (es) 2017-06-21 2021-01-29 SHY Therapeutics LLC Compuestos que interaccionan con la superfamilia ras para el tratamiento de cancer, enfermedades inflamatorias, rasopatias y enfermedad fibrotica.

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH317906A (de) 1953-09-16 1956-12-15 Sandoz Ag Verfahren zur Herstellung von 1-Amino-4-oxyanthrachinonsulfonsäuren
AU521790B2 (en) 1977-05-23 1982-04-29 Ici Australia Limited Process for eradication of ticks
US4196207A (en) 1977-05-23 1980-04-01 Ici Australia Limited Process for controlling eradicating or preventing infestations of animals by Ixodid ticks
DD226893A1 (de) 1981-12-15 1985-09-04 Ralf Boehm Verfahren zur herstellung von arylaminosubstituierten thieno 2,3-d pyrimidinen
IL112569A (en) 1994-02-10 1999-12-22 Wyeth John & Brother Ltd Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation
IL112568A0 (en) 1994-02-10 1995-05-26 Wyeth John & Brother Ltd Substituted quinolines, their preparation and pharmaceutical compositions containing them
IL112566A (en) 1994-02-10 2000-10-31 Wyeth John & Brother Ltd Substituted quinolinones and pharmaceutical compositions containing them
IL112567A (en) 1994-02-10 2000-02-29 Wyeth John & Brother Ltd Substituted quinolines their preparation and pharmaceutical compositions containing them
CA2227384A1 (en) 1995-08-17 1997-02-27 Toshifumi Watanabe Thienopyrimidine derivatives, their production and use
AU713573B2 (en) 1996-07-26 1999-12-02 Nissan Chemical Industries Ltd. Chroman derivatives
US6083986A (en) 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US5969017A (en) 1996-10-31 1999-10-19 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US5935945A (en) 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
RU2116309C1 (ru) 1997-02-13 1998-07-27 Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского 4-[(бензо-2,1,3-тиадиазолил-4)амино]-5,6,7,8-тетрагидробензотиено [2,3-d]пиримидин, обладающий противогельминтной активностью при ларвальном альвеолярном эхинококкозе
US6333337B1 (en) 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
CA2334258A1 (en) 1998-06-05 1999-12-09 Icagen, Inc. Potassium channel inhibitors
AU5444499A (en) 1998-09-01 2000-03-21 Nissan Chemical Industries Ltd. Benzoxazine derivatives
US6194458B1 (en) 1998-10-30 2001-02-27 Merck & Co., Inc. Benzamide potassium channel inhibitors
DE19929076A1 (de) 1999-06-25 2000-12-28 Aventis Pharma Gmbh Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
SK3292002A3 (en) 1999-09-17 2003-04-01 Nissan Chemical Ind Ltd Benzopyran derivative
US6555574B1 (en) 1999-09-24 2003-04-29 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
US6531495B1 (en) 1999-10-02 2003-03-11 Aventis Pharma Deutschland Gmbh 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them
DE19947457A1 (de) 1999-10-02 2001-04-05 Aventis Pharma Gmbh 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
AU7453900A (en) 1999-10-05 2001-05-10 Nissan Chemical Industries Ltd. 4-oxybenzopyran derivative
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
AU781365B2 (en) 1999-12-21 2005-05-19 Icagen, Inc. Potassium channel inhibitors
JP4854909B2 (ja) 2000-09-20 2012-01-18 メルク・シャープ・エンド・ドーム・コーポレイション イソキノリノン系カリウムチャンネル阻害剤
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10059418A1 (de) 2000-11-30 2002-06-20 Aventis Pharma Gmbh Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10060807A1 (de) 2000-12-07 2002-06-20 Aventis Pharma Gmbh Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10061876A1 (de) 2000-12-12 2002-06-20 Aventis Pharma Gmbh Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10104802A1 (de) 2001-02-02 2002-08-08 Merck Patent Gmbh Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (1)
CA2437085A1 (en) 2001-02-02 2002-08-15 Merck Patent Gesellschaft Mit Beschraenkter Haftung Pharmaceutical formulation comprising pyrazolo[4,3-d]pyrimidines and endothelin receptor antagonists or thienopyrimidines and endothelin receptor antagonists
TW589305B (en) 2001-02-14 2004-06-01 Nissan Chemical Ind Ltd 4-aminobenzopyran derivatives
DE10121003A1 (de) 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10121002A1 (de) 2001-04-28 2002-11-14 Aventis Pharma Gmbh Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen
DE10128331A1 (de) 2001-06-12 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
CN1279036C (zh) 2001-06-25 2006-10-11 日产化学工业株式会社 抗心律失常的取代的苯并吡喃衍生物
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
ES2324536T7 (es) 2003-06-11 2012-03-16 Xention Limited Derivados de tenopirimidina como inhibidores de los canales de potasio.
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
CN1845918A (zh) * 2003-07-02 2006-10-11 沃泰克斯药物股份有限公司 可用作电压-门控离子通道调节剂的嘧啶
US7557111B2 (en) 2004-01-06 2009-07-07 Taisho Pharmaceutical Co., Ltd. Substituted thieno[3,2-d]pyrimidines as CRF receptor antagonists
WO2006004658A2 (en) 2004-06-29 2006-01-12 Amgen Inc. Furanopyrimidines
JP5173429B2 (ja) 2004-12-09 2013-04-03 ゼンション・リミテッド 化合物
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
WO2007084815A2 (en) 2006-01-19 2007-07-26 Janssen Pharmaceutica, N.V. Substituted thienopyrimidine kinase inhibitors
EP2043654A2 (en) * 2006-06-12 2009-04-08 Vertex Pharmaceuticals, Inc. Thienopyrimidines useful as modulators of ion channels
DE102009039893B4 (de) 2009-09-03 2012-03-29 Bundesanstalt für Materialforschung und -Prüfung (BAM) Verwendung eines Brennstoffs in einem selbstunterhaltenden pulsierenden Sauerstoff-Brennstoff-Verbrennungsprozess

Also Published As

Publication number Publication date
KR20140023332A (ko) 2014-02-26
UA110131C2 (ru) 2015-11-25
CU24173B1 (es) 2016-04-25
CR20130488A (es) 2013-12-06
ZA201307085B (en) 2015-04-29
SMT201500322B (it) 2016-02-25
WO2012131379A1 (en) 2012-10-04
HK1193806A1 (zh) 2014-10-03
AR088735A1 (es) 2014-07-02
CN103492392A (zh) 2014-01-01
EP2694518A1 (en) 2014-02-12
ME02314B (me) 2016-06-20
BR112013025236A2 (pt) 2019-09-24
US9249155B2 (en) 2016-02-02
CL2013002789A1 (es) 2014-07-18
IL228555A0 (en) 2013-12-31
RS54458B1 (en) 2016-06-30
US20140206703A1 (en) 2014-07-24
AU2012235882B2 (en) 2015-08-06
ES2558563T3 (es) 2016-02-05
NZ615621A (en) 2015-01-30
EP2694518B1 (en) 2015-10-07
SI2694518T1 (sl) 2016-02-29
GB201105659D0 (en) 2011-05-18
RU2013148627A (ru) 2015-05-10
TN2013000377A1 (en) 2015-01-20
CO6801756A2 (es) 2013-11-29
NI201300100A (es) 2014-01-07
CN103492392B (zh) 2015-11-25
TW201244720A (en) 2012-11-16
GT201300225A (es) 2014-12-30
CU20130124A7 (es) 2014-01-29
EA201301111A1 (ru) 2014-02-28
CA2831493A1 (en) 2012-10-04
ECSP13012988A (es) 2013-12-31
MX2013011301A (es) 2014-04-16
CY1117025T1 (el) 2017-04-05
AU2012235882A1 (en) 2013-05-02
TWI516265B (zh) 2016-01-11
DK2694518T3 (en) 2015-11-09
PE20141021A1 (es) 2014-08-30
MX335937B (es) 2016-01-04
MA35064B1 (fr) 2014-04-03
PT2694518E (pt) 2016-02-05
SG193578A1 (en) 2013-10-30
HRP20151340T1 (hr) 2016-02-26
AP2013007198A0 (en) 2013-10-31
JP5826374B2 (ja) 2015-12-02
PL2694518T3 (pl) 2016-03-31
JP2014509637A (ja) 2014-04-21
HUE028438T2 (en) 2017-02-28

Similar Documents

Publication Publication Date Title
HRP20180771T1 (hr) Derivati pirolo[3,2-d]pirimidina za liječenje virusnih infekcija i drugih bolesti
HK1222659A1 (zh) 吡咯並 嘧啶衍生物,它們的製備方法和它們作爲激酶抑制劑的用途
IL227526A0 (en) Derivatives of 6-cyclobutyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidine-4-one and their use as a9pde inhibitors
HK1204987A1 (zh) 用於治療、改善或預防病毒疾病的 -氧代- -二氫-吡唑並 嘧啶衍生物
AP3417A (en) Pyrazolo [1,5-a] pyrimidines as antiviral agents
PT2794611T (pt) Pirazolo[1,5-a]pirimidinas como agentes antivirais
EP2751112A4 (en) SUBSTITUTED PYRAZOLO [3,4-D] PYRIMIDINES AND USES THEREOF
AP2012006631A0 (en) 6-Cycloalkyl-1, 5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivatives and their use as PDE9A inhibitors
HK1176236A1 (zh) 噻唑並 嘧啶以及它們作為農用化學品的用途
AP2013007147A0 (en) Use of substituted 2,3-dihydroimidazo[1,2-C]quinyzolines
HK1200447A1 (zh) -吡咯並 吡啶衍生物及它們作為激酶抑制劑的用途
EP2739627A4 (en) 2,3-DIHYDROIMIDAZO [1,2-C] PYRIMIDIN-5 (1H) -ONE COMPOUNDS AND USE AS INHIBITORS OF LP-PLA2
ZA201406323B (en) Triazolo[4,5-d]pyrimidine derivatives
HK1209740A1 (zh) 二噁烯並-和噁嗪- 嘧啶 抑制劑化合物及使用方法
ZA201307511B (en) Pyrido [2,3-b] pyrazine derivatives and their therapeutical uses
HK1193806A1 (zh) 噻吩並 嘧啶衍生物及其用於治療心律失常的用途
HK1205504A1 (zh) 取代的吡唑並 吡啶、其製備及作為藥物的應用
EP2835372A4 (en) THIOPHENE [2, 3-D] PYRIMIDINE DERIVATIVE AND METHOD OF PREPARATION AND USE
ZA201402226B (en) 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d] pyrimidine derivatives, their manufacture and their use as antiviral active substances

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200331