HRP20151340T1 - Derivati tieno[2,3-d] pirimidina i njihova primjena u lijeäśenju aritmije - Google Patents
Derivati tieno[2,3-d] pirimidina i njihova primjena u lijeäśenju aritmije Download PDFInfo
- Publication number
- HRP20151340T1 HRP20151340T1 HRP20151340TT HRP20151340T HRP20151340T1 HR P20151340 T1 HRP20151340 T1 HR P20151340T1 HR P20151340T T HRP20151340T T HR P20151340TT HR P20151340 T HRP20151340 T HR P20151340T HR P20151340 T1 HRP20151340 T1 HR P20151340T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- thieno
- pyrimidine derivatives
- arrhythmia
- Prior art date
Links
- 206010003119 arrhythmia Diseases 0.000 title claims 3
- 230000006793 arrhythmia Effects 0.000 title claims 3
- DDWBRNXDKNIQDY-UHFFFAOYSA-N thieno[2,3-d]pyrimidine Chemical class N1=CN=C2SC=CC2=C1 DDWBRNXDKNIQDY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 3
- 102000004257 Potassium Channel Human genes 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 108020001213 potassium channel Proteins 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (13)
1. Spoj formule (Ia)
[image]
ili njegov farmaceutski prihvatljiv ester ili sol.
2. Spoj iz patentnog zahtjeva 1, naznačen time da je spoj formule (Ib)
[image]
3. Spoj iz patentnog zahtjeva 1, naznačen time da je spoj formule (Ic)
[image]
4. Spoj iz patentnog zahtjeva 1, naznačen time da spoj formule (Ia) sadrži smjesu spojeva formula (Ib) i (Ic).
5. Spoj iz patentnog zahtjeva 4, naznačen time da spoj formule (Ia) sadrži racemsku smjesu spojeva formula (Ib) i (Ic).
6. Spoj iz patentnog zahtjeva 4, naznačen time da spoj formule (Ia) sadrži enantiomerni suvišak spoja formule (Ib).
7. Spoj iz patentnog zahtjeva 4, naznačen time da spoj formule (Ia) sadrži enantiomerni suvišak spoja formule (Ic).
8. Farmaceutski pripravak naznačen time da sadrži najmanje jedan spoj prema bilo kojem od patentnih zahtjeva od 1 do 7 i, po želji jedan ili više farmaceutski prihvatljivih ekscipijenata.
9. Spoj ili pripravak prema bilo kojem od patentnih zahtjeva od 1 do 8 naznačen time da je za upotrebu u terapiji.
10. Spoj ili pripravak prema bilo kojem od patentnih zahtjeva od 1 do 8 naznačen time da je za upotrebu u inhibiranju kalijevog kanala.
11. Spoj ili pripravak prema patentnom zahtjevu 10, naznačen time da je spoj ili pripravak za upotrebu u tretmanu ili prevenciji aritmije.
12. Upotreba spoja prema bilo kojem od patentnih zahtjeva od 1 do 7 naznačena time da je za proizvodnju medikamenta koji se primjenjuje u inhibiranju kalijevog kanala.
13. Upotreba prema patentnom zahtjevu 12 naznačena time da je medikament za upotrebu u tretmanu ili prevenciji aritmije.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1105659.5A GB201105659D0 (en) | 2011-04-01 | 2011-04-01 | Compounds |
| PCT/GB2012/050710 WO2012131379A1 (en) | 2011-04-01 | 2012-03-29 | Thieno [2, 3 -d] pyrimidine derivatives and their use to treat arrhythmia |
| EP12718725.0A EP2694518B1 (en) | 2011-04-01 | 2012-03-29 | Thieno[2,3-d]pyrimidine derivatives and their use to treat arrhythmia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20151340T1 true HRP20151340T1 (hr) | 2016-02-26 |
Family
ID=44071904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151340TT HRP20151340T1 (hr) | 2011-04-01 | 2015-12-08 | Derivati tieno[2,3-d] pirimidina i njihova primjena u lijeäśenju aritmije |
Country Status (42)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014078957A1 (en) * | 2012-11-20 | 2014-05-30 | The Royal Institution For The Advancement Of Learning/Mcgill University | Thienopyrimidine inhibitors of farnesyl and/or geranylgeranyl pyrophosphate synthase |
| AU2016378723B2 (en) | 2015-12-22 | 2021-09-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
| IL310023A (en) | 2017-06-21 | 2024-03-01 | SHY Therapeutics LLC | Compounds interacting with the RAS superfamily for the treatment of cancer, inflammation, RAS pathology and fibrotic diseases |
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| DD226893A1 (de) | 1981-12-15 | 1985-09-04 | Ralf Boehm | Verfahren zur herstellung von arylaminosubstituierten thieno 2,3-d pyrimidinen |
| WO1997007119A1 (en) | 1994-08-26 | 1997-02-27 | Takeda Chemical Industries, Ltd. | Thienopyrimidine derivatives, their production and use |
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| IL112569A (en) | 1994-02-10 | 1999-12-22 | Wyeth John & Brother Ltd | Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation |
| IL112567A (en) | 1994-02-10 | 2000-02-29 | Wyeth John & Brother Ltd | Substituted quinolines their preparation and pharmaceutical compositions containing them |
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| RU2116309C1 (ru) | 1997-02-13 | 1998-07-27 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | 4-[(бензо-2,1,3-тиадиазолил-4)амино]-5,6,7,8-тетрагидробензотиено [2,3-d]пиримидин, обладающий противогельминтной активностью при ларвальном альвеолярном эхинококкозе |
| US6333337B1 (en) | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
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| WO2000012492A1 (en) | 1998-09-01 | 2000-03-09 | Nissan Chemical Industries, Ltd. | Benzoxazine derivatives |
| US6194458B1 (en) | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
| DE19929076A1 (de) | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
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| DE19947457A1 (de) | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
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-
2011
- 2011-04-01 GB GBGB1105659.5A patent/GB201105659D0/en not_active Ceased
-
2012
- 2012-03-29 CU CUP2013000124A patent/CU24173B1/es unknown
- 2012-03-29 WO PCT/GB2012/050710 patent/WO2012131379A1/en active Application Filing
- 2012-03-29 KR KR1020137028742A patent/KR20140023332A/ko not_active Application Discontinuation
- 2012-03-29 AU AU2012235882A patent/AU2012235882B2/en not_active Ceased
- 2012-03-29 EA EA201301111A patent/EA201301111A1/ru unknown
- 2012-03-29 PE PE2013002093A patent/PE20141021A1/es not_active Application Discontinuation
- 2012-03-29 UA UAA201312693A patent/UA110131C2/ru unknown
- 2012-03-29 EP EP12718725.0A patent/EP2694518B1/en active Active
- 2012-03-29 HU HUE12718725A patent/HUE028438T2/en unknown
- 2012-03-29 SG SG2013071147A patent/SG193578A1/en unknown
- 2012-03-29 US US14/008,776 patent/US9249155B2/en not_active Expired - Fee Related
- 2012-03-29 JP JP2014501722A patent/JP5826374B2/ja not_active Expired - Fee Related
- 2012-03-29 CN CN201280016323.9A patent/CN103492392B/zh not_active Expired - Fee Related
- 2012-03-29 BR BR112013025236A patent/BR112013025236A2/pt not_active IP Right Cessation
- 2012-03-29 RS RS20150833A patent/RS54458B1/en unknown
- 2012-03-29 ME MEP-2015-219A patent/ME02314B/me unknown
- 2012-03-29 SI SI201230406T patent/SI2694518T1/sl unknown
- 2012-03-29 MA MA36364A patent/MA35064B1/fr unknown
- 2012-03-29 MX MX2013011301A patent/MX335937B/es unknown
- 2012-03-29 CA CA2831493A patent/CA2831493A1/en not_active Abandoned
- 2012-03-29 PT PT127187250T patent/PT2694518E/pt unknown
- 2012-03-29 AP AP2013007198A patent/AP2013007198A0/xx unknown
- 2012-03-29 DK DK12718725.0T patent/DK2694518T3/en active
- 2012-03-29 ES ES12718725.0T patent/ES2558563T3/es active Active
- 2012-03-29 PL PL12718725T patent/PL2694518T3/pl unknown
- 2012-03-29 RU RU2013148627/04A patent/RU2013148627A/ru not_active Application Discontinuation
- 2012-03-30 TW TW101111540A patent/TWI516265B/zh not_active IP Right Cessation
- 2012-03-30 AR ARP120101121A patent/AR088735A1/es unknown
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2013
- 2013-09-19 ZA ZA2013/07085A patent/ZA201307085B/en unknown
- 2013-09-24 TN TNP2013000377A patent/TN2013000377A1/fr unknown
- 2013-09-26 CR CR20130488A patent/CR20130488A/es not_active Application Discontinuation
- 2013-09-26 GT GT201300225A patent/GT201300225A/es unknown
- 2013-09-27 CL CL2013002789A patent/CL2013002789A1/es unknown
- 2013-09-29 IL IL228555A patent/IL228555A0/en unknown
- 2013-09-30 NI NI201300100A patent/NI201300100A/es unknown
- 2013-10-23 EC ECSP13012988 patent/ECSP13012988A/es unknown
- 2013-10-24 CO CO13252150A patent/CO6801756A2/es active IP Right Grant
-
2014
- 2014-06-30 HK HK14106566.5A patent/HK1193096A1/zh not_active IP Right Cessation
- 2014-07-14 HK HK14107118.6A patent/HK1193806A1/zh not_active IP Right Cessation
-
2015
- 2015-12-07 CY CY20151101110T patent/CY1117025T1/el unknown
- 2015-12-08 HR HRP20151340TT patent/HRP20151340T1/hr unknown
- 2015-12-22 SM SM201500322T patent/SMT201500322B/it unknown
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