MX2014014832A - Pirrolopirimidona y pirrolopiridona, inhibidores de tanquirasa. - Google Patents

Pirrolopirimidona y pirrolopiridona, inhibidores de tanquirasa.

Info

Publication number
MX2014014832A
MX2014014832A MX2014014832A MX2014014832A MX2014014832A MX 2014014832 A MX2014014832 A MX 2014014832A MX 2014014832 A MX2014014832 A MX 2014014832A MX 2014014832 A MX2014014832 A MX 2014014832A MX 2014014832 A MX2014014832 A MX 2014014832A
Authority
MX
Mexico
Prior art keywords
pyrrolopyrimidone
pyrrolopyridone
tankyrase
inhibitors
compounds
Prior art date
Application number
MX2014014832A
Other languages
English (en)
Inventor
Johannes Cornelius Hermann
Nancy-Ellen Haynes
Nathan Robert Scott
Kyungjin Kim
Mark Zak
Yi Lin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014014832A publication Critical patent/MX2014014832A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Se proporcionan compuestos de la fórmula (I): (ver Fórmula) en la que Q, R1 y R2 tienen los significados aquí definidos. Los compuestos tienen actividad como agentes anticancerosos.
MX2014014832A 2012-06-07 2013-06-05 Pirrolopirimidona y pirrolopiridona, inhibidores de tanquirasa. MX2014014832A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261656650P 2012-06-07 2012-06-07
PCT/EP2013/061525 WO2013182580A1 (en) 2012-06-07 2013-06-05 Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase

Publications (1)

Publication Number Publication Date
MX2014014832A true MX2014014832A (es) 2015-02-12

Family

ID=48628628

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014014832A MX2014014832A (es) 2012-06-07 2013-06-05 Pirrolopirimidona y pirrolopiridona, inhibidores de tanquirasa.

Country Status (13)

Country Link
US (1) US8722661B2 (es)
EP (1) EP2858995A1 (es)
JP (1) JP2015522557A (es)
KR (1) KR20150005711A (es)
CN (1) CN104350056A (es)
AR (1) AR091271A1 (es)
BR (1) BR112014030416A2 (es)
CA (1) CA2873723A1 (es)
HK (1) HK1202112A1 (es)
MX (1) MX2014014832A (es)
RU (1) RU2014151004A (es)
TW (1) TW201402576A (es)
WO (1) WO2013182580A1 (es)

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CN104395314A (zh) * 2012-06-20 2015-03-04 霍夫曼-拉罗奇有限公司 端锚聚合酶抑制剂吡咯并吡嗪酮
CA2922469A1 (en) 2013-09-11 2015-03-19 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
CN106459057B (zh) 2014-04-10 2019-06-07 湖北生物医药产业技术研究院有限公司 作为PARP抑制剂的4H-吡唑并[1,5-α]苯并咪唑化合物的类似物
KR101739003B1 (ko) * 2014-07-11 2017-05-23 에스티팜 주식회사 신규한 트리아졸로피리미디논 또는 트리아졸로피리디논 유도체, 및 이들의 용도
WO2016006974A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel triazolopyrimidinone or triazolopyridinone derivatives, and use thereof
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
CN107286169B (zh) * 2016-04-05 2020-11-24 北京四环制药有限公司 端锚聚合酶抑制剂
NZ749946A (en) * 2016-06-30 2023-11-24 Yakult Honsha Kk Novel compound or pharmaceutically acceptable salt thereof
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
JP7288161B2 (ja) 2017-12-27 2023-06-07 国立研究開発法人理化学研究所 新規ジヒドロキナゾリノン系化合物又はその薬理学的に許容される塩、及び細胞増殖阻害剤
US20210060016A1 (en) 2017-12-27 2021-03-04 Japanese Foundation For Cancer Research Anticancer agent
WO2023101048A1 (ko) * 2021-12-01 2023-06-08 에스티팜 주식회사 트리아졸로피리미디논 유도체의 제조방법

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AP1411A (en) * 1998-06-02 2005-05-10 Osi Pharm Inc Pyrrolo[2,3d] pyrimidine compositions and their use.
US6878716B1 (en) * 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
EP1731520A1 (en) * 1999-12-02 2006-12-13 OSI Pharmaceuticals, Inc. Pyrrolo[2,3-d]pyrimidine derivatives which are antagonists of adenosine A1, A2A, and A3
AU3540101A (en) * 2000-01-07 2001-07-16 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
PL363245A1 (en) * 2000-12-01 2004-11-15 Osi Pharmaceuticals, Inc. Compounds specific to adenosine a1
WO2002094790A1 (fr) * 2001-05-23 2002-11-28 Mitsubishi Pharma Corporation Compose heterocyclique condense et son utilisation medicale
CN100374441C (zh) * 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
AU2005259190B2 (en) * 2004-06-30 2011-05-12 Janssen Pharmaceutica N.V. Quinazolinedione derivatives as PARP inhibitors
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Also Published As

Publication number Publication date
CA2873723A1 (en) 2013-12-12
AR091271A1 (es) 2015-01-21
KR20150005711A (ko) 2015-01-14
US20130331375A1 (en) 2013-12-12
RU2014151004A (ru) 2016-08-10
HK1202112A1 (en) 2015-09-18
TW201402576A (zh) 2014-01-16
BR112014030416A2 (pt) 2017-06-27
US8722661B2 (en) 2014-05-13
WO2013182580A1 (en) 2013-12-12
EP2858995A1 (en) 2015-04-15
JP2015522557A (ja) 2015-08-06
CN104350056A (zh) 2015-02-11

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