ATE495176T1 - Spiroindolinon-derivate - Google Patents

Spiroindolinon-derivate

Info

Publication number
ATE495176T1
ATE495176T1 AT07726742T AT07726742T ATE495176T1 AT E495176 T1 ATE495176 T1 AT E495176T1 AT 07726742 T AT07726742 T AT 07726742T AT 07726742 T AT07726742 T AT 07726742T AT E495176 T1 ATE495176 T1 AT E495176T1
Authority
AT
Austria
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
agents
spiroindolinones
Prior art date
Application number
AT07726742T
Other languages
English (en)
Inventor
Qingjie Ding
Jin-Jun Liu
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE495176T1 publication Critical patent/ATE495176T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT07726742T 2006-03-13 2007-03-09 Spiroindolinon-derivate ATE495176T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78195806P 2006-03-13 2006-03-13
US89998707P 2007-02-07 2007-02-07
PCT/EP2007/052220 WO2007104714A1 (en) 2006-03-13 2007-03-09 Spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
ATE495176T1 true ATE495176T1 (de) 2011-01-15

Family

ID=38176544

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07726742T ATE495176T1 (de) 2006-03-13 2007-03-09 Spiroindolinon-derivate

Country Status (10)

Country Link
EP (1) EP1996591B1 (de)
JP (1) JP2009530236A (de)
KR (1) KR101052706B1 (de)
AT (1) ATE495176T1 (de)
AU (1) AU2007224452A1 (de)
BR (1) BRPI0708883A2 (de)
CA (1) CA2644758A1 (de)
DE (1) DE602007011902D1 (de)
IL (1) IL193620A0 (de)
WO (1) WO2007104714A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070213341A1 (en) * 2006-03-13 2007-09-13 Li Chen Spiroindolinone derivatives
US8134001B2 (en) * 2007-12-14 2012-03-13 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US7928233B2 (en) 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
FR2967072B1 (fr) 2010-11-05 2013-03-29 Univ Dundee Procede pour ameliorer la production de virus et semences vaccinales influenza
TR201807311T4 (tr) 2011-03-10 2018-06-21 Daiichi Sankyo Co Ltd Dispiropirolidin derivesi.
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
ES2707305T3 (es) 2012-12-20 2019-04-03 Merck Sharp & Dohme Imidazopiridinas sustituidas como inhibidores de HDM2
KR102389552B1 (ko) * 2014-04-17 2022-04-22 더 리젠츠 오브 더 유니버시티 오브 미시간 Mdm2 저해제 및 이 저해제를 사용하는 치료 방법
JP6503386B2 (ja) 2014-07-03 2019-04-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体
CA2956129C (en) 2014-08-21 2022-10-25 Boehringer Ingelheim International Gmbh New spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
CN107427501B (zh) 2015-02-20 2023-12-01 第一三共株式会社 通过联合使用治疗癌症的方法
KR20170134462A (ko) 2015-04-13 2017-12-06 다이이찌 산쿄 가부시키가이샤 Mdm2 저해제와 btk 저해제의 병용 치료법
PL3359542T3 (pl) 2015-10-09 2021-09-20 Boehringer Ingelheim International Gmbh Związki i pochodne spiro[3h-indolo-3,2’-pirolidyno]-2(1h)-onowe jako inhibitory mdm2-p53
EP3458101B1 (de) 2016-05-20 2020-12-30 H. Hoffnabb-La Roche Ag Protac-antikörper-konjugate und verfahren zur verwendung
WO2018074387A1 (ja) 2016-10-17 2018-04-26 第一三共株式会社 Ｍｄｍ２阻害剤とｄｎａメチルトランスフェラーゼ阻害剤との併用治療法
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2002203A3 (cs) * 1999-07-21 2002-08-14 Astrazeneca Ab Spirooxindolové deriváty

Also Published As

Publication number Publication date
CA2644758A1 (en) 2007-09-20
IL193620A0 (en) 2009-05-04
KR20080094727A (ko) 2008-10-23
JP2009530236A (ja) 2009-08-27
AU2007224452A1 (en) 2007-09-20
WO2007104714A1 (en) 2007-09-20
EP1996591B1 (de) 2011-01-12
EP1996591A1 (de) 2008-12-03
DE602007011902D1 (de) 2011-02-24
KR101052706B1 (ko) 2011-08-01
BRPI0708883A2 (pt) 2011-06-14

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