ATE495176T1 - Spiroindolinon-derivate - Google Patents
Spiroindolinon-derivateInfo
- Publication number
- ATE495176T1 ATE495176T1 AT07726742T AT07726742T ATE495176T1 AT E495176 T1 ATE495176 T1 AT E495176T1 AT 07726742 T AT07726742 T AT 07726742T AT 07726742 T AT07726742 T AT 07726742T AT E495176 T1 ATE495176 T1 AT E495176T1
- Authority
- AT
- Austria
- Prior art keywords
- spiroindolinone derivatives
- spiroindolinone
- derivatives
- agents
- spiroindolinones
- Prior art date
Links
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78195806P | 2006-03-13 | 2006-03-13 | |
| US89998707P | 2007-02-07 | 2007-02-07 | |
| PCT/EP2007/052220 WO2007104714A1 (en) | 2006-03-13 | 2007-03-09 | Spiroindolinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495176T1 true ATE495176T1 (de) | 2011-01-15 |
Family
ID=38176544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07726742T ATE495176T1 (de) | 2006-03-13 | 2007-03-09 | Spiroindolinon-derivate |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1996591B1 (de) |
| JP (1) | JP2009530236A (de) |
| KR (1) | KR101052706B1 (de) |
| AT (1) | ATE495176T1 (de) |
| AU (1) | AU2007224452A1 (de) |
| BR (1) | BRPI0708883A2 (de) |
| CA (1) | CA2644758A1 (de) |
| DE (1) | DE602007011902D1 (de) |
| IL (1) | IL193620A0 (de) |
| WO (1) | WO2007104714A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070213341A1 (en) * | 2006-03-13 | 2007-09-13 | Li Chen | Spiroindolinone derivatives |
| US8134001B2 (en) | 2007-12-14 | 2012-03-13 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US7776875B2 (en) * | 2007-12-19 | 2010-08-17 | Hoffman-La Roche Inc. | Spiroindolinone derivatives |
| US7928233B2 (en) | 2009-02-10 | 2011-04-19 | Hoffmann-La Roche Inc. | Spiroindolinone pyridine derivatives |
| US8217051B2 (en) | 2009-02-17 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US8076482B2 (en) | 2009-04-23 | 2011-12-13 | Hoffmann-La Roche Inc. | 3,3′-spiroindolinone derivatives |
| US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
| US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
| US8217044B2 (en) | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
| FR2967072B1 (fr) | 2010-11-05 | 2013-03-29 | Univ Dundee | Procede pour ameliorer la production de virus et semences vaccinales influenza |
| DK2684880T3 (en) | 2011-03-10 | 2018-05-22 | Daiichi Sankyo Co Ltd | DISPIROPYRROLIDINE DERIVATIVES |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| EP2935263B1 (de) | 2012-12-20 | 2018-12-05 | Merck Sharp & Dohme Corp. | Substituierte imidazopyridine als hdm2 inhibitoren |
| EP3131544B1 (de) * | 2014-04-17 | 2018-12-12 | The Regents of the University of Michigan | Mdm2-hemmer und therapeutische verfahren damit |
| JP6503386B2 (ja) | 2014-07-03 | 2019-04-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体 |
| ES2739697T3 (es) | 2014-08-21 | 2020-02-03 | Boehringer Ingelheim Int | Nuevos compuestos y derivados de espiro[3H-indol-3,2-pirrolidin]-2(1H)-ona como inhibidores de MDM2-p53 |
| EP3260119B1 (de) | 2015-02-20 | 2023-11-15 | Daiichi Sankyo Company, Limited | Kombinationsverfahren zur behandlung von krebs |
| US10485794B2 (en) | 2015-04-13 | 2019-11-26 | Daiichi Sankyo Company, Limited | Treatment method by combined use of MDM2 inhibitor and BTK inhibitor |
| HRP20210960T1 (hr) | 2015-10-09 | 2021-09-03 | Boehringer Ingelheim International Gmbh | Spojevi i derivati spiro[3h-indol-3,2’-pirolidin]-2(1h)-ona kao inhibitori mdm2-p53 |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| EP3527226A4 (de) | 2016-10-17 | 2020-06-17 | Daiichi Sankyo Company, Limited | Kombinationstherapieverfahren mit mdm2-inhibitor und dna-methyltransferase-inhibitor |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200200118T2 (tr) * | 1999-07-21 | 2002-12-23 | Astrazeneca Ab | Yeni bileşimler |
-
2007
- 2007-03-09 CA CA002644758A patent/CA2644758A1/en not_active Abandoned
- 2007-03-09 BR BRPI0708883-3A patent/BRPI0708883A2/pt not_active IP Right Cessation
- 2007-03-09 AU AU2007224452A patent/AU2007224452A1/en not_active Abandoned
- 2007-03-09 EP EP07726742A patent/EP1996591B1/de not_active Not-in-force
- 2007-03-09 WO PCT/EP2007/052220 patent/WO2007104714A1/en not_active Ceased
- 2007-03-09 AT AT07726742T patent/ATE495176T1/de active
- 2007-03-09 KR KR1020087022506A patent/KR101052706B1/ko not_active Expired - Fee Related
- 2007-03-09 DE DE602007011902T patent/DE602007011902D1/de active Active
- 2007-03-09 JP JP2008558791A patent/JP2009530236A/ja not_active Ceased
-
2008
- 2008-08-21 IL IL193620A patent/IL193620A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009530236A (ja) | 2009-08-27 |
| WO2007104714A1 (en) | 2007-09-20 |
| KR20080094727A (ko) | 2008-10-23 |
| DE602007011902D1 (de) | 2011-02-24 |
| KR101052706B1 (ko) | 2011-08-01 |
| IL193620A0 (en) | 2009-05-04 |
| CA2644758A1 (en) | 2007-09-20 |
| AU2007224452A1 (en) | 2007-09-20 |
| BRPI0708883A2 (pt) | 2011-06-14 |
| EP1996591B1 (de) | 2011-01-12 |
| EP1996591A1 (de) | 2008-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602007011902D1 (de) | Spiroindolinon-derivate | |
| TW200801000A (en) | Spiroindolinone derivatives | |
| BRPI0820699A2 (pt) | derivados de espieoindolina | |
| BRPI0821255A2 (pt) | Derivados de espiroindolinona | |
| MX2012009186A (es) | Pirrolidina-2-carboxamidas sustituidas. | |
| MY160424A (en) | Substituted pyrrolidine-2-carboxyamides. | |
| MX2007004699A (es) | Derivados de indol y bencimidazol. | |
| MX2011008176A (es) | Derivados de 3,3'-espiroindolinona como agentes anticancerigenos. | |
| NO20083630L (no) | Nye pyridinderivater | |
| MX2009009774A (es) | Derivados de quinolina como fungicidas. | |
| PH12012501905A1 (en) | Quinoline derivatives and their use as fungicides | |
| TW200612958A (en) | Substituted imidazole derivatives | |
| MX2012003982A (es) | Pirrolidinas n-substituidas. | |
| BRPI0717266A2 (pt) | Derivados de oxindol | |
| EA201200049A1 (ru) | 1,3-дизамещенные производные имидазолидин-2-она в качестве ингибиторов cyp 17 | |
| TNSN08178A1 (en) | Triazolopyridine derivatives as inhibitors of lipases and phospholipases | |
| MX2011007886A (es) | Derivado de espiroindolinona piridina. | |
| ATE528290T1 (de) | Spiroindolinon-derivate | |
| BRPI0511433A (pt) | derivados de quinolina substituìda como inibidores de cinesina mitótica | |
| TN2009000178A1 (en) | Substituted pyrazole and triazole compounds as ksp inhibitors | |
| NO20084543L (no) | Benzimidazolderivater | |
| MX2009003169A (es) | Derivados de sulfonamida. | |
| TW200800951A (en) | Substituted imidazole compounds as KSP inhibitors | |
| ATE469647T1 (de) | Thienoä3,2-cüpyridin-7-carbonsäure-derivate | |
| EA200970692A1 (ru) | Способы улучшения стабильности стероидных производных |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1996591 Country of ref document: EP |