AR058128A1 - Compuesto de pirazolil carbamato y formulacion farmaceutica que lo comprende - Google Patents
Compuesto de pirazolil carbamato y formulacion farmaceutica que lo comprendeInfo
- Publication number
- AR058128A1 AR058128A1 ARP060104596A ARP060104596A AR058128A1 AR 058128 A1 AR058128 A1 AR 058128A1 AR P060104596 A ARP060104596 A AR P060104596A AR P060104596 A ARP060104596 A AR P060104596A AR 058128 A1 AR058128 A1 AR 058128A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- group
- 4alkyl
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Preferentemente, el compuesto es: 1-{1-[1-(1-metil-ciclopropancarbonil)-piperidin-4-iloxi]-isoquinolin-4-il}-3-[5-(1-dimetil-ciclopropil)-2-p-tolil-2H-pirazol-3-il]urea. Composicion farmacéutica que lo comprende. Se emplea como inhibidor de cinasa p38, especialmente en el tratamiento de dolencias derivadas de excesiva produccion de citosina tales como necrosis de tumores, neoplasmas, metástasis o artritis reumatoide. Reivindicacion 1: Un compuesto de pirazolil carbamato caracterizado porque es de formula (1) donde X se selecciona del grupo que consiste de formulas (2) y (3); R1 es alquilo C1-4, cicloalquilo C3-4 opcionalmente sustituido con uno o dos sustituyentes seleccionados del grupo de alcoxi C1-4, metilo y trifluorometilo; 1 alquilhalo C1-4, R2 es un fenilo opcionalmente sustituido con alquilo C1-4, o piridinilo, opcionalmente sustituido con alquilo C1-4; R3 es amino, alquilo C1-4, alcoxi C1-4, alquilhalo C1-4, cicloalquilo C3-4 opcionalmente sustituido con un primer sustituyente seleccionado del grupo que consiste de: metilo, trifluorometilo o halo; fenilo o tienilo, cada uno opcionalmente sustituido con un primer sustituyentes seleccionado del grupo que consiste de; halo, alquilo C1-4, y alcoxi C1-4, y opcionalmente además sustituido con un segundo sustituyente seleccionado de halo; o una sal del mismo farmacéuticamente aceptable.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05380240 | 2005-10-28 | ||
| US75020005P | 2005-12-14 | 2005-12-14 | |
| EP06380097 | 2006-04-26 | ||
| US82196406P | 2006-08-10 | 2006-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058128A1 true AR058128A1 (es) | 2008-01-23 |
Family
ID=43298632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104596A AR058128A1 (es) | 2005-10-28 | 2006-10-20 | Compuesto de pirazolil carbamato y formulacion farmaceutica que lo comprende |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7582638B2 (es) |
| EP (1) | EP1943244A1 (es) |
| JP (1) | JP2009513639A (es) |
| KR (1) | KR101013303B1 (es) |
| AR (1) | AR058128A1 (es) |
| AU (1) | AU2006309174B2 (es) |
| BR (1) | BRPI0617828A2 (es) |
| CA (1) | CA2627670A1 (es) |
| DO (1) | DOP2006000233A (es) |
| EA (1) | EA015123B1 (es) |
| PE (1) | PE20070640A1 (es) |
| TW (1) | TW200800194A (es) |
| WO (1) | WO2007053346A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008125014A1 (fr) * | 2007-04-13 | 2008-10-23 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. | Composés d'urée, leurs procédés de préparation et leurs utilisations pharmaceutiques |
| EP2039676A1 (en) * | 2007-09-19 | 2009-03-25 | Huntsman International Llc | Process for the production of di-and polyamines of the diphenylmethane series |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| ES2583853T3 (es) | 2011-10-03 | 2016-09-22 | Respivert Limited | 1-Pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il)ureas como inhibidores de p38 MAP cinasa |
| GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
| WO2014076484A1 (en) | 2012-11-16 | 2014-05-22 | Respivert Limited | Kinase inhibitors |
| WO2014140582A1 (en) | 2013-03-14 | 2014-09-18 | Respivert Limited | Kinase inhibitors |
| CA3054161A1 (en) | 2017-03-30 | 2018-10-04 | F. Hoffmann-La Roche Ag | Isoquinolines as inhibitors of hpk1 |
| BR112020006677A2 (pt) | 2017-10-05 | 2020-10-06 | Fulcrum Therapeutics, Inc. | uso de inibidores p38 para reduzir a expressão de dux4 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73492C2 (en) * | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
| US20060063782A1 (en) * | 2002-07-03 | 2006-03-23 | Murray Christopher W | 3-Hetero arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors |
| EP1609789A1 (en) * | 2004-06-23 | 2005-12-28 | Eli Lilly And Company | Ureido-pyrazole derivatives and their use as kinase inhibitors |
| SI1761520T1 (sl) * | 2004-06-23 | 2008-10-31 | Lilly Co Eli | Inhibitorji kinaze |
-
2006
- 2006-10-20 PE PE2006001274A patent/PE20070640A1/es not_active Application Discontinuation
- 2006-10-20 TW TW095138681A patent/TW200800194A/zh unknown
- 2006-10-20 AR ARP060104596A patent/AR058128A1/es unknown
- 2006-10-20 DO DO2006000233A patent/DOP2006000233A/es unknown
- 2006-10-23 KR KR1020087010067A patent/KR101013303B1/ko not_active IP Right Cessation
- 2006-10-23 BR BRPI0617828-6A patent/BRPI0617828A2/pt not_active IP Right Cessation
- 2006-10-23 EP EP06817284A patent/EP1943244A1/en not_active Withdrawn
- 2006-10-23 JP JP2008537837A patent/JP2009513639A/ja not_active Withdrawn
- 2006-10-23 AU AU2006309174A patent/AU2006309174B2/en not_active Expired - Fee Related
- 2006-10-23 EA EA200801200A patent/EA015123B1/ru not_active IP Right Cessation
- 2006-10-23 WO PCT/US2006/041266 patent/WO2007053346A1/en active Application Filing
- 2006-10-23 CA CA002627670A patent/CA2627670A1/en not_active Abandoned
- 2006-10-23 US US12/089,420 patent/US7582638B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0617828A2 (pt) | 2011-08-09 |
| US7582638B2 (en) | 2009-09-01 |
| AU2006309174A1 (en) | 2007-05-10 |
| JP2009513639A (ja) | 2009-04-02 |
| EA015123B1 (ru) | 2011-06-30 |
| TW200800194A (en) | 2008-01-01 |
| WO2007053346A1 (en) | 2007-05-10 |
| CA2627670A1 (en) | 2007-05-10 |
| KR101013303B1 (ko) | 2011-02-09 |
| US20080275056A1 (en) | 2008-11-06 |
| EP1943244A1 (en) | 2008-07-16 |
| PE20070640A1 (es) | 2007-08-10 |
| EA200801200A1 (ru) | 2008-08-29 |
| AU2006309174B2 (en) | 2011-10-13 |
| KR20080053514A (ko) | 2008-06-13 |
| DOP2006000233A (es) | 2007-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |