EA201490993A1 - МОДИФИЦИРОВАННЫЕ СРЕДСТВА РНКи - Google Patents

МОДИФИЦИРОВАННЫЕ СРЕДСТВА РНКи

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Publication number
EA201490993A1
EA201490993A1 EA201490993A EA201490993A EA201490993A1 EA 201490993 A1 EA201490993 A1 EA 201490993A1 EA 201490993 A EA201490993 A EA 201490993A EA 201490993 A EA201490993 A EA 201490993A EA 201490993 A1 EA201490993 A1 EA 201490993A1
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EA
Eurasian Patent Office
Prior art keywords
dsrna
target gene
inhibiting
expression
rna
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EA201490993A
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English (en)
Inventor
Каллантхоттатхил Г. Раджив
Трэйси Циммерманн
Мутхиах Манохаран
Мартин Майер
Сатиянараяна Кучиманчи
Клаус Хариссе
Original Assignee
Элнилэм Фармасьютикалз, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47295193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490993(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Publication of EA201490993A1 publication Critical patent/EA201490993A1/ru

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

Abstract

Один аспект настоящего изобретения относится к дуплексному средству двухцепочечной РНКи (дцРНК), способному ингибировать экспрессию гена-мишени. Дуплекс дцРНК содержит один или несколько мотивов из трех идентичных модификаций на трех последовательных нуклеотидах в одной или обеих цепях, в частности в сайте расщепления цепи или вблизи него. Другие аспекты изобретения относятся к фармацевтическим композициям, содержащим такие средства дцРНК, подходящих для терапевтического применения, и способам ингибирования экспрессии гена-мишени путем введения таких средств дцРНК, например, для лечения различных болезненных состояний.
EA201490993A 2011-11-18 2012-11-16 МОДИФИЦИРОВАННЫЕ СРЕДСТВА РНКи EA201490993A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561710P 2011-11-18 2011-11-18
PCT/US2012/065601 WO2013074974A2 (en) 2011-11-18 2012-11-16 Modified rnai agents

Publications (1)

Publication Number Publication Date
EA201490993A1 true EA201490993A1 (ru) 2014-09-30

Family

ID=47295193

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490993A EA201490993A1 (ru) 2011-11-18 2012-11-16 МОДИФИЦИРОВАННЫЕ СРЕДСТВА РНКи

Country Status (20)

Country Link
US (5) US9796974B2 (ru)
EP (3) EP2780454A2 (ru)
JP (4) JP2015502931A (ru)
KR (3) KR20230074615A (ru)
CN (3) CN104105790A (ru)
AR (1) AR121312A2 (ru)
CA (1) CA2856289A1 (ru)
DK (1) DK3366775T3 (ru)
EA (1) EA201490993A1 (ru)
ES (1) ES2923787T3 (ru)
HK (1) HK1200191A1 (ru)
HR (1) HRP20220908T8 (ru)
IL (2) IL303831A (ru)
IN (1) IN2014CN03465A (ru)
LT (1) LT3366775T (ru)
MX (2) MX359548B (ru)
NZ (1) NZ797319A (ru)
SG (1) SG11201402382XA (ru)
SI (1) SI3366775T1 (ru)
WO (1) WO2013074974A2 (ru)

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