MX368084B - siRNA Y SU USO EN LA PREPARACIÓN DE UN MEDICAMENTO PARA USARSE EN UN MÉTODO PARA EL TRATAMIENTO DE UN TRANSTORNO OCULAR. - Google Patents
siRNA Y SU USO EN LA PREPARACIÓN DE UN MEDICAMENTO PARA USARSE EN UN MÉTODO PARA EL TRATAMIENTO DE UN TRANSTORNO OCULAR.Info
- Publication number
- MX368084B MX368084B MX2015002800A MX2015002800A MX368084B MX 368084 B MX368084 B MX 368084B MX 2015002800 A MX2015002800 A MX 2015002800A MX 2015002800 A MX2015002800 A MX 2015002800A MX 368084 B MX368084 B MX 368084B
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- methods
- sirna
- prevention
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
La presente invención se refiere al uso de siRNA en la preparación de un medicamento para usarse en un método para el tratamiento de un trastorno ocular caracterizado por elevación de la presión intraocular (IOP), empleando dosis que disminuyen la IOP del ojo, que comprende una molécula de siRNA bicatenaria de 19 nucleótidos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2012/052177 WO2014037686A1 (en) | 2012-09-05 | 2012-09-05 | Sirna and their use in methods and compositions for the treatment and/or prevention of eye conditions |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015002800A MX2015002800A (es) | 2015-07-17 |
MX368084B true MX368084B (es) | 2019-09-19 |
Family
ID=46889366
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015002800A MX368084B (es) | 2012-09-05 | 2012-09-05 | siRNA Y SU USO EN LA PREPARACIÓN DE UN MEDICAMENTO PARA USARSE EN UN MÉTODO PARA EL TRATAMIENTO DE UN TRANSTORNO OCULAR. |
Country Status (19)
Country | Link |
---|---|
US (1) | US10011832B2 (es) |
EP (1) | EP2893018B1 (es) |
JP (1) | JP2015533792A (es) |
KR (1) | KR102120060B1 (es) |
CN (1) | CN104781402A (es) |
AU (1) | AU2012389270B2 (es) |
BR (1) | BR112015004452A2 (es) |
CA (1) | CA2883007A1 (es) |
CL (1) | CL2015000538A1 (es) |
EC (1) | ECSP15011105A (es) |
ES (1) | ES2750125T3 (es) |
HK (1) | HK1211983A1 (es) |
IL (1) | IL237403B (es) |
IN (1) | IN2015DN02699A (es) |
MX (1) | MX368084B (es) |
RU (1) | RU2653766C2 (es) |
SG (1) | SG11201501385UA (es) |
WO (1) | WO2014037686A1 (es) |
ZA (1) | ZA201502181B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2653766C2 (ru) | 2012-09-05 | 2018-05-14 | Силентис С.А.У. | КиРНК И ИХ ИСПОЛЬЗОВАНИЕ В СПОСОБАХ И КОМПОЗИЦИЯХ ДЛЯ ЛЕЧЕНИЯ И/ИЛИ ПРОФИЛАКТИКИ ГЛАЗНЫХ ЗАБОЛЕВАНИЙ |
US10011837B2 (en) | 2014-03-04 | 2018-07-03 | Sylentis Sau | SiRNAs and their use in methods and compositions for the treatment and/or prevention of eye conditions |
Family Cites Families (66)
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US4343794A (en) | 1980-05-06 | 1982-08-10 | Mt. Sinai | Method of reducing intraocular pressure with salts of vanadic acid |
US4652586A (en) | 1980-11-07 | 1987-03-24 | The General Hospital Corporation | Selective beta-2 adrenergic antagonists for the treatment of glaucoma |
SU986484A1 (ru) * | 1981-07-20 | 1983-01-07 | Каунасский Политехнический Институт Им.Антанаса Снечкуса | Дозатор жидкости |
US4617299A (en) | 1983-12-19 | 1986-10-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
US5242943A (en) | 1984-03-28 | 1993-09-07 | William J. Louis | 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them |
US4812448A (en) | 1984-10-22 | 1989-03-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
US4757089A (en) | 1985-06-14 | 1988-07-12 | Massachusetts Eye And Ear Infirmary | Increasing aqueous humor outflow |
US5075323A (en) | 1988-08-24 | 1991-12-24 | Aktiebolaget Hassle | Compounds including omeprazole in the treatment of glaucoma |
US5260059A (en) | 1989-04-14 | 1993-11-09 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University | Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor |
RU2039539C1 (ru) * | 1990-09-27 | 1995-07-20 | Менчел Йехошуа | Насадка для установки на флаконе с лекарственной жидкостью и устройство для распределения глазной жидкости |
US6372249B1 (en) | 1991-12-16 | 2002-04-16 | Baylor College Of Medicine | Senscent cell-derived inhibitors of DNA synthesis |
US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
US5545626A (en) | 1994-01-19 | 1996-08-13 | The Trustees Of Columbia University In The City Of New York | Method of treating glaucoma with oligonucleotides |
US5585401A (en) | 1994-12-09 | 1996-12-17 | The Reents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
US20020055536A1 (en) | 1996-09-26 | 2002-05-09 | Dewitte Robert S. | System and method for structure-based drug design that includes accurate prediction of binding free energy |
US6489307B1 (en) | 1998-09-14 | 2002-12-03 | University Of Florida | Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use |
EP1147204A1 (en) | 1999-01-28 | 2001-10-24 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
US6365576B1 (en) | 1999-06-24 | 2002-04-02 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method for inhibiting herpes infection |
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US20040209832A1 (en) | 2001-11-30 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US20030148987A1 (en) | 2001-12-21 | 2003-08-07 | Morris David J. | Selective 11beta-HSD inhibitors and methods of use thereof |
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-
2012
- 2012-09-05 RU RU2015112131A patent/RU2653766C2/ru active
- 2012-09-05 CN CN201280076706.5A patent/CN104781402A/zh active Pending
- 2012-09-05 JP JP2015530486A patent/JP2015533792A/ja active Pending
- 2012-09-05 KR KR1020157008532A patent/KR102120060B1/ko active IP Right Grant
- 2012-09-05 SG SG11201501385UA patent/SG11201501385UA/en unknown
- 2012-09-05 EP EP12762372.6A patent/EP2893018B1/en active Active
- 2012-09-05 WO PCT/GB2012/052177 patent/WO2014037686A1/en active Application Filing
- 2012-09-05 ES ES12762372T patent/ES2750125T3/es active Active
- 2012-09-05 BR BR112015004452A patent/BR112015004452A2/pt not_active Application Discontinuation
- 2012-09-05 AU AU2012389270A patent/AU2012389270B2/en active Active
- 2012-09-05 US US14/425,466 patent/US10011832B2/en active Active
- 2012-09-05 MX MX2015002800A patent/MX368084B/es active IP Right Grant
- 2012-09-05 IN IN2699DEN2015 patent/IN2015DN02699A/en unknown
- 2012-09-05 CA CA2883007A patent/CA2883007A1/en not_active Abandoned
-
2015
- 2015-02-25 IL IL23740315A patent/IL237403B/en active IP Right Grant
- 2015-03-04 CL CL2015000538A patent/CL2015000538A1/es unknown
- 2015-03-23 EC ECIEPI201511105A patent/ECSP15011105A/es unknown
- 2015-03-30 ZA ZA2015/02181A patent/ZA201502181B/en unknown
-
2016
- 2016-01-05 HK HK16100040.2A patent/HK1211983A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2012389270A1 (en) | 2015-02-26 |
ZA201502181B (en) | 2016-01-27 |
US20150259677A1 (en) | 2015-09-17 |
RU2653766C2 (ru) | 2018-05-14 |
ECSP15011105A (es) | 2015-12-31 |
IN2015DN02699A (es) | 2015-09-04 |
JP2015533792A (ja) | 2015-11-26 |
KR102120060B1 (ko) | 2020-06-09 |
KR20150048880A (ko) | 2015-05-07 |
EP2893018B1 (en) | 2019-07-24 |
AU2012389270B2 (en) | 2018-11-08 |
WO2014037686A1 (en) | 2014-03-13 |
CL2015000538A1 (es) | 2015-07-31 |
BR112015004452A2 (pt) | 2017-08-08 |
CN104781402A (zh) | 2015-07-15 |
IL237403B (en) | 2019-11-28 |
HK1211983A1 (en) | 2016-06-03 |
ES2750125T3 (es) | 2020-03-25 |
US10011832B2 (en) | 2018-07-03 |
RU2015112131A (ru) | 2016-10-27 |
SG11201501385UA (en) | 2015-03-30 |
CA2883007A1 (en) | 2014-03-13 |
IL237403A0 (en) | 2015-04-30 |
MX2015002800A (es) | 2015-07-17 |
EP2893018A1 (en) | 2015-07-15 |
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Legal Events
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FG | Grant or registration |