SG10201804960RA - Complement component irna compositions and methods of use thereof - Google Patents

Complement component irna compositions and methods of use thereof

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Publication number
SG10201804960RA
SG10201804960RA SG10201804960RA SG10201804960RA SG10201804960RA SG 10201804960R A SG10201804960R A SG 10201804960RA SG 10201804960R A SG10201804960R A SG 10201804960RA SG 10201804960R A SG10201804960R A SG 10201804960RA SG 10201804960R A SG10201804960R A SG 10201804960RA
Authority
SG
Singapore
Prior art keywords
complement component
methods
irna
compositions
gene
Prior art date
Application number
SG10201804960RA
Inventor
Anna Borodovsky
Brian Bettencourt
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of SG10201804960RA publication Critical patent/SG10201804960RA/en

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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

COMPLEMENT COMPONENT IRNA COMPOSITIONS AND METHODS OF USE THEREOF The invention relates to iRNA, e.g., double- stranded ribonucleic acid (dsRNA), compositions targeting the complement factor B (CFB) gene, the complement component C3 gene, and the complement component C9 gene and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of CFB, C9 and/or C3 and to treat subjects having a complement component-associated disease, e.g., paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. [Figure 1]
SG10201804960RA 2013-12-12 2014-12-12 Complement component irna compositions and methods of use thereof SG10201804960RA (en)

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KR101141544B1 (en) 2009-03-13 2012-05-03 한국과학기술원 Multi-conjugate of siRNA and preparing method thereof
AU2014362262B2 (en) 2013-12-12 2021-05-13 Alnylam Pharmaceuticals, Inc. Complement component iRNA compositions and methods of use thereof
PE20170010A1 (en) * 2014-05-01 2017-03-04 Ionis Pharmaceuticals Inc COMPOSITIONS AND METHODS TO MODULATE THE EXPRESSION OF THE COMPLEMENT FACTOR B
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