NZ776080A - Modified rnai agents - Google Patents

Modified rnai agents

Info

Publication number
NZ776080A
NZ776080A NZ776080A NZ77608012A NZ776080A NZ 776080 A NZ776080 A NZ 776080A NZ 776080 A NZ776080 A NZ 776080A NZ 77608012 A NZ77608012 A NZ 77608012A NZ 776080 A NZ776080 A NZ 776080A
Authority
NZ
New Zealand
Prior art keywords
dsrna
rnai agents
strand
modified rnai
agents
Prior art date
Application number
NZ776080A
Inventor
Muthiah Manoharan
Martin Maier
Kallanthottathil Rajeev
Tracy Zimmermann
Satyanarayana Kuchimanchi
Klaus Charisse
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Priority to NZ797319A priority Critical patent/NZ797319B2/en
Publication of NZ776080A publication Critical patent/NZ776080A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene. The dsRNA duplex comprises one or more motifs of three identical modifications on three consecutive nucleotides in one or both strand, particularly at or near the cleavage site of the strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents and the use of such dsRNA agents in the manufacture of a medicament for delivering a polynucleotide to a specific target in a subject.
NZ776080A 2011-11-18 2012-11-16 Modified rnai agents NZ776080A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ797319A NZ797319B2 (en) 2012-11-16 Modified RNAi agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561710P 2011-11-18 2011-11-18
NZ75880912 2012-11-16

Publications (1)

Publication Number Publication Date
NZ776080A true NZ776080A (en) 2023-05-26

Family

ID=86613248

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ776080A NZ776080A (en) 2011-11-18 2012-11-16 Modified rnai agents

Country Status (1)

Country Link
NZ (1) NZ776080A (en)

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Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 9 YEARS UNTIL 16 NOV 2025 BY IPAN GMBH

Effective date: 20231012