MX2018013216A - Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6). - Google Patents

Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).

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Publication number
MX2018013216A
MX2018013216A MX2018013216A MX2018013216A MX2018013216A MX 2018013216 A MX2018013216 A MX 2018013216A MX 2018013216 A MX2018013216 A MX 2018013216A MX 2018013216 A MX2018013216 A MX 2018013216A MX 2018013216 A MX2018013216 A MX 2018013216A
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MX
Mexico
Prior art keywords
compositions
methods
inhibiting expression
tmprss6 gene
tmprss6
Prior art date
Application number
MX2018013216A
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English (en)
Inventor
David Bumcrot
Brian Bettencourt
Ivanka Toudjarska
Original Assignee
Alnylam Pharmaceuticals Inc
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Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2018013216A publication Critical patent/MX2018013216A/es

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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

La invención se refiere a composiciones de ácido ribonucleico de doble hebra (ARNdh) que se dirigen al gen TMPRSS6, y a métodos de uso de las composiciones de ARNdh para inhibir la expresión de TMPRSS6.
MX2018013216A 2011-03-29 2013-09-27 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6). MX2018013216A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161468830P 2011-03-29 2011-03-29
US201161568942P 2011-12-09 2011-12-09

Publications (1)

Publication Number Publication Date
MX2018013216A true MX2018013216A (es) 2022-08-24

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Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016013802A MX360349B (es) 2011-03-29 2012-03-28 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).
MX2013011177A MX343008B (es) 2011-03-29 2012-03-28 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).
MX2018013216A MX2018013216A (es) 2011-03-29 2013-09-27 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).

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Application Number Title Priority Date Filing Date
MX2016013802A MX360349B (es) 2011-03-29 2012-03-28 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).
MX2013011177A MX343008B (es) 2011-03-29 2012-03-28 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).

Country Status (13)

Country Link
US (4) US9175290B2 (es)
EP (2) EP3674409A1 (es)
JP (5) JP6108628B2 (es)
KR (4) KR102271245B1 (es)
CN (2) CN103813810B (es)
AU (4) AU2012236700B2 (es)
BR (1) BR112013025006B1 (es)
CA (2) CA3217805A1 (es)
MX (3) MX360349B (es)
PH (1) PH12017501501A1 (es)
RU (1) RU2702501C2 (es)
SG (2) SG193923A1 (es)
WO (1) WO2012135246A2 (es)

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EP2776564B1 (en) * 2011-11-07 2019-10-02 Ionis Pharmaceuticals, Inc. Modulation of tmprss6 expression
AR096203A1 (es) 2013-05-06 2015-12-16 Alnylam Pharmaceuticals Inc Dosificaciones y métodos para administrar moléculas de ácido nucleico formuladas en lípidos
KR102365809B1 (ko) * 2013-05-22 2022-02-23 알닐람 파마슈티칼스 인코포레이티드 Ｔｍｐｒｓｓ6 조성물 및 이의 사용 방법
EP3052626A1 (en) 2013-10-02 2016-08-10 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the lect2 gene
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WO2016161429A1 (en) * 2015-04-03 2016-10-06 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating tmprss6 expression
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CN110177544A (zh) 2016-11-29 2019-08-27 普尔泰克健康有限公司 用于递送治疗剂的外泌体
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WO2019105419A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
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EP3719126A4 (en) 2017-12-01 2021-10-20 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING NUCLEIC ACID, ASSOCIATED PREPARATION PROCESS AND USE
JP7436030B2 (ja) 2017-12-29 2024-02-21 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 複合体及びその調製方法と使用
EP3598995A1 (en) * 2018-07-26 2020-01-29 Silence Therapeutics GmbH Products and compositions
CN111655849A (zh) 2018-08-21 2020-09-11 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
CN111655297A (zh) 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
CN111973619B (zh) * 2019-05-23 2024-01-30 苏州瑞博生物技术股份有限公司 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
IL307926A (en) 2021-04-26 2023-12-01 Alnylam Pharmaceuticals Inc Transmembrane assemblies, serine 6 ((TMPRSS6 IRNA) and methods of using them
WO2022229150A1 (en) 2021-04-27 2022-11-03 Silence Therapeutics Gmbh Sirna targeting tmprss6 for the treawtment of myeloproliferative disorders
TW202400193A (zh) 2022-06-24 2024-01-01 丹麥商諾佛 儂迪克股份有限公司 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
WO2024060649A1 (zh) * 2022-09-29 2024-03-28 广州必贝特医药股份有限公司 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用

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