ES2172595T3 - Compuestos de 1-acil-4-alifatilaminopiperidina. - Google Patents
Compuestos de 1-acil-4-alifatilaminopiperidina.Info
- Publication number
- ES2172595T3 ES2172595T3 ES95933394T ES95933394T ES2172595T3 ES 2172595 T3 ES2172595 T3 ES 2172595T3 ES 95933394 T ES95933394 T ES 95933394T ES 95933394 T ES95933394 T ES 95933394T ES 2172595 T3 ES2172595 T3 ES 2172595T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- amino
- substituted
- alkylene
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE 1-ACIL-4ALIFATILAMINOPIPERIDINA, DE FORMULA (I), EN LA QUE R{SUB,1} ES UN RADICAL BENZOILO, NAFTOILO, O CICLOALCANOILO, SUSTITUIDO O SIN SUSTITUIR CON ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO Y/O TRIFLUOROMETILO; R{SUB,2} ES CICLOALQUILO O UN RADICAL FENILO O NAFTILO, QUE ESTA SUSTITUIDO O NO SUSTITUIDO POR ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO, NITRO, CIANO Y/O TRIFLUOROMETILO; R{SUB,3} Y R{SUB,4} UNIDOS, SON ALQUILENO INFERIOR O AZA-, OXA-, O TIA-ALQUILENO INFERIOR; O R{SUB,3} ES ALQUILO INFERIOR, ALCOXI INFERIOR-ALQUILO INFERIOR, DIALQUILAMINO INFERIOR-ALQUILO INFERIOR, O UN RADICAL DE FORMULA -(CH{SUB,2}){SUB,N}-C(=O)-R{SUB,5} (IA); Y R{SUB,4} ES HIDROGENO, ALQUILO INFERIOR, O UN RADICAL DE FORMULA -(CH{SUB,2}){SUB,N}C(=O)-R{SUB,5} (IA); R{SUB,5} ES (I) HIDROGENO, ALQUILO O ALQUILO SUSTITUIDO POR HALOGENO, ALCOXI INFERIOR, AMINO O AMINO SUSTITUIDO POR ALQUILO INFERIOR, AMINO-ALQUILO INFERIOR, NONOO DI-ALQUILAMINOALQUILO INFERIOR, ALCANOILO INFERIOR, ALCOXICARBONILO INFERIOR, O ALQUILENO INFERIOR O AZA-, OXA- O TIA-ALQUILENO INFERIOR, (II) HIDROXILO, CICLOALCOXI, ALCOXI INFERIOR O ALCOXI INFERIOR SUSTITUIDO CON ALCOXI INFERIOR, AMINO O AMINO SUSTITUIDO CON ALQUILO INFERIOR, AMINO-ALQUILO INFERIOR, MONO- O DI-ALQUILAMINO INFERIOR-ALQUILO, ALCANOILO INFERIOR, ALCOXICARBONILO INFERIOR, O ALQUILENO INFERIOR, O AZA-, OXA- O TIA-ALQUILENO INFERIOR, O (III) AMINO O AMINO SUSTITUIDO CON ALQUILO INFERIOR, CICLOALQUILO, AMINO-ALQUILO INFERIOR, MONO- O DI-ALQUILAMINOALQUILO INFERIOR, ALCANOILO INFERIOR, ALCOXICARBONILO INFERIOR O ALQUILENO INFERIOR, O AZA-, OXA- O TIA-ALQUILENO INFERIOR; X{SUB,1} ES METILENO, ETILENO, UN ENLACE DIRECTO, UN GRUPO CARBONILO LIBRE O CETALIZADO, O UN GRUPO HIDROXIMETILENO LIBRE O ETERIFICADO; Y N ES 0 O 1; ASI COMO SUS SALES, PROCEDIMIENTOS DE PREPARACION DE LOS COMPUESTOS DESCRITOS EN LA INVENCION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, Y SU UTILIZACION COMO INGREDIENTES FARMACEUTICAMENTE ACTIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH296694 | 1994-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2172595T3 true ES2172595T3 (es) | 2002-10-01 |
Family
ID=4245651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95933394T Expired - Lifetime ES2172595T3 (es) | 1994-09-30 | 1995-09-19 | Compuestos de 1-acil-4-alifatilaminopiperidina. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5935951A (es) |
EP (1) | EP0783490B1 (es) |
JP (1) | JPH10506399A (es) |
AT (1) | ATE212981T1 (es) |
AU (1) | AU3607895A (es) |
CA (1) | CA2198382A1 (es) |
DE (1) | DE69525355T2 (es) |
DK (1) | DK0783490T3 (es) |
ES (1) | ES2172595T3 (es) |
FI (1) | FI971260A0 (es) |
HU (1) | HUT77318A (es) |
NO (1) | NO971383L (es) |
PT (1) | PT783490E (es) |
WO (1) | WO1996010562A1 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW475930B (en) * | 1995-04-24 | 2002-02-11 | Novartis Ag | Novel compound, its use and pharmaceutical composition comprising it |
NZ321575A (en) * | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
TW429256B (en) * | 1995-12-27 | 2001-04-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives |
TW531537B (en) | 1995-12-27 | 2003-05-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives |
GB0025354D0 (en) * | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
DE10112198A1 (de) * | 2001-03-14 | 2002-09-19 | Gruenenthal Gmbh | Substituierte Dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amine |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
EP1472222A1 (en) | 2002-02-08 | 2004-11-03 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases |
GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
NZ552397A (en) | 2004-07-15 | 2011-04-29 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
ATE478075T1 (de) | 2005-03-08 | 2010-09-15 | Janssen Pharmaceutica Nv | Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten |
WO2006123182A2 (en) | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Cyclohexyl sulphones for treatment of cancer |
EP1904069B1 (en) | 2005-07-15 | 2018-06-13 | Albany Molecular Research, Inc. | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
BRPI0616463A2 (pt) | 2005-09-29 | 2011-06-21 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
EP2060563A4 (en) * | 2006-09-08 | 2010-12-22 | Dainippon Sumitomo Pharma Co | CYCLIC AMINOALKYLCARBOXAMIDE DERIVATIVE |
WO2008039327A2 (en) | 2006-09-22 | 2008-04-03 | Merck & Co., Inc. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
AU2008204380B2 (en) | 2007-01-10 | 2013-08-15 | Msd Italia S.R.L. | Amide substituted indazoles as poly(ADP-ribose)polymerase (PARP) inhibitors |
EP2145884B1 (en) | 2007-04-02 | 2014-08-06 | Msd K.K. | Indoledione derivative |
US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
JP2011515343A (ja) | 2008-03-03 | 2011-05-19 | タイガー ファーマテック | チロシンキナーゼ阻害薬 |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
EP2413932A4 (en) | 2009-04-01 | 2012-09-19 | Merck Sharp & Dohme | INHIBITORS OF AKT ACTIVITY |
BRPI1007737A2 (pt) * | 2009-04-20 | 2015-09-01 | Auspex Pharmaceuticals Llc | "composto da fórmula estrutural i, composição farmacêutica, método de tratamento de um distúbio mediano por janus quinase 3, método de preparação de um composto da fórmula estrutural ii, e método de preparação de um composto da fórmula estrutural xii" |
KR20120034644A (ko) | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도 |
NZ596104A (en) | 2009-05-12 | 2014-01-31 | Albany Molecular Res Inc | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
KR20120023072A (ko) | 2009-05-12 | 2012-03-12 | 브리스톨-마이어스 스큅 컴퍼니 | (S)-7-(〔1,2,4〕트리아졸〔1,5-a〕피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린의 결정형 및 이의 용도 |
BR112012008849A2 (pt) | 2009-10-14 | 2015-09-22 | Schering Corp | composto, composição farmacêutica, e, uso de um composto |
EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
JP6043285B2 (ja) | 2010-08-02 | 2016-12-14 | サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. | 低分子干渉核酸(siNA)を用いたカテニン(カドヘリン結合型タンパク質)β1(CTNNB1)遺伝子発現のRNA干渉媒介性阻害 |
HUE044815T2 (hu) | 2010-08-17 | 2019-11-28 | Sirna Therapeutics Inc | Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával |
EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
WO2012036997A1 (en) | 2010-09-16 | 2012-03-22 | Schering Corporation | Fused pyrazole derivatives as novel erk inhibitors |
US9260471B2 (en) | 2010-10-29 | 2016-02-16 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
US20140045847A1 (en) | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
DK2729147T3 (en) | 2011-07-04 | 2017-12-18 | Irbm - Science Park S P A | NK-1 RECEPTOR ANTAGONISTS FOR TREATMENT OF CORNOVA |
WO2013063214A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
US9233979B2 (en) | 2012-09-28 | 2016-01-12 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
BR112015012295A8 (pt) | 2012-11-28 | 2023-03-14 | Merck Sharp & Dohme | Uso de um inibidor de wee1, e, kit para identificar um paciente com câncer |
BR112015013611A2 (pt) | 2012-12-20 | 2017-11-14 | Merck Sharp & Dohme | composto, e, composição farmacêutica |
EP2951180B1 (en) | 2013-01-30 | 2018-05-02 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
RU2020131446A (ru) | 2018-02-26 | 2022-03-28 | Оспедале Сан Раффаэле С.Р.Л. | Антагонисты nk-1 для применения в лечении глазной боли |
EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
EP4117673A1 (en) | 2020-03-11 | 2023-01-18 | Ospedale San Raffaele S.r.l. | Treatment of stem cell deficiency |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8804104D0 (en) * | 1988-02-23 | 1988-03-23 | Glaxo Group Ltd | Chemical compounds |
MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
EP0600952B1 (en) * | 1991-08-20 | 1996-04-17 | MERCK SHARP & DOHME LTD. | Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them |
WO1995011895A1 (en) * | 1993-10-26 | 1995-05-04 | Ciba-Geigy Ag | N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists |
-
1995
- 1995-09-19 JP JP8511331A patent/JPH10506399A/ja not_active Ceased
- 1995-09-19 EP EP95933394A patent/EP0783490B1/en not_active Expired - Lifetime
- 1995-09-19 PT PT95933394T patent/PT783490E/pt unknown
- 1995-09-19 HU HU9701800A patent/HUT77318A/hu unknown
- 1995-09-19 AU AU36078/95A patent/AU3607895A/en not_active Abandoned
- 1995-09-19 US US08/809,277 patent/US5935951A/en not_active Expired - Fee Related
- 1995-09-19 ES ES95933394T patent/ES2172595T3/es not_active Expired - Lifetime
- 1995-09-19 AT AT95933394T patent/ATE212981T1/de not_active IP Right Cessation
- 1995-09-19 DE DE69525355T patent/DE69525355T2/de not_active Expired - Fee Related
- 1995-09-19 WO PCT/EP1995/003681 patent/WO1996010562A1/en active IP Right Grant
- 1995-09-19 DK DK95933394T patent/DK0783490T3/da active
- 1995-09-19 CA CA002198382A patent/CA2198382A1/en not_active Abandoned
-
1997
- 1997-03-24 NO NO971383A patent/NO971383L/no unknown
- 1997-03-26 FI FI971260A patent/FI971260A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1996010562A1 (en) | 1996-04-11 |
NO971383D0 (no) | 1997-03-24 |
JPH10506399A (ja) | 1998-06-23 |
DE69525355D1 (de) | 2002-03-21 |
US5935951A (en) | 1999-08-10 |
HUT77318A (hu) | 1998-03-30 |
EP0783490A1 (en) | 1997-07-16 |
ATE212981T1 (de) | 2002-02-15 |
EP0783490B1 (en) | 2002-02-06 |
FI971260A (fi) | 1997-03-26 |
AU3607895A (en) | 1996-04-26 |
NO971383L (no) | 1997-05-14 |
PT783490E (pt) | 2002-06-28 |
FI971260A0 (fi) | 1997-03-26 |
DK0783490T3 (da) | 2002-05-13 |
MX9702092A (es) | 1997-10-31 |
CA2198382A1 (en) | 1996-04-11 |
DE69525355T2 (de) | 2002-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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