DE69412067T2 - Substituierte spiro-azaringen als tachykinine rezeptor antagonisten - Google Patents
Substituierte spiro-azaringen als tachykinine rezeptor antagonistenInfo
- Publication number
- DE69412067T2 DE69412067T2 DE69412067T DE69412067T DE69412067T2 DE 69412067 T2 DE69412067 T2 DE 69412067T2 DE 69412067 T DE69412067 T DE 69412067T DE 69412067 T DE69412067 T DE 69412067T DE 69412067 T2 DE69412067 T2 DE 69412067T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- receptor antagonists
- tachykinine
- azaringes
- substituted spiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1023393A | 1993-01-28 | 1993-01-28 | |
PCT/US1994/000819 WO1994017045A1 (en) | 1993-01-28 | 1994-01-25 | Spiro-substituted azacycles as tachykinin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69412067D1 DE69412067D1 (de) | 1998-09-03 |
DE69412067T2 true DE69412067T2 (de) | 1999-03-25 |
Family
ID=21744688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69412067T Expired - Fee Related DE69412067T2 (de) | 1993-01-28 | 1994-01-25 | Substituierte spiro-azaringen als tachykinine rezeptor antagonisten |
Country Status (10)
Country | Link |
---|---|
US (1) | US5869496A (de) |
EP (1) | EP0681571B1 (de) |
JP (1) | JPH08505880A (de) |
AT (1) | ATE169001T1 (de) |
AU (1) | AU693087B2 (de) |
CA (1) | CA2154569A1 (de) |
DE (1) | DE69412067T2 (de) |
DK (1) | DK0681571T3 (de) |
ES (1) | ES2119174T3 (de) |
WO (1) | WO1994017045A1 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
US5434158A (en) * | 1994-04-26 | 1995-07-18 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin-3 antagonists |
TW432061B (en) * | 1994-08-09 | 2001-05-01 | Pfizer Res & Dev | Lactams |
GB9421709D0 (en) * | 1994-10-27 | 1994-12-14 | Zeneca Ltd | Therapeutic compounds |
AU715558B2 (en) * | 1995-11-23 | 2000-02-03 | Merck Sharp & Dohme Limited | Spiro-piperidine derivatives and their use as tachykinin antagonists |
RU2135494C1 (ru) | 1995-12-01 | 1999-08-27 | Санкио Компани Лимитед | Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина |
GB9603136D0 (en) * | 1996-02-15 | 1996-04-17 | Merck Sharp & Dohme | Therapeutic agents |
GB9603137D0 (en) * | 1996-02-15 | 1996-04-17 | Merck Sharp & Dohme | Therapeutic agents |
US5756743A (en) * | 1996-04-10 | 1998-05-26 | Hoechst Marion Roussel Inc. | Spiro cyclopent b!indole-piperidines! |
NZ332777A (en) * | 1996-06-21 | 2000-06-23 | Merck Sharp & Dohme | 3,6-bi-phenyl substituted spiro-piperidine derivatives |
US5945428A (en) * | 1996-11-01 | 1999-08-31 | Schering Corporation | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
US5962462A (en) * | 1996-12-13 | 1999-10-05 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
US5783579A (en) * | 1996-12-20 | 1998-07-21 | Schering Corporation | Spiro-substituted azacyclic-substituted piperazino derivatives as neurokinin antagonists |
GB9711114D0 (en) | 1997-05-29 | 1997-07-23 | Merck Sharp & Dohme | Therapeutic agents |
US6013644A (en) * | 1997-12-12 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
HUP0100939A3 (en) | 1998-01-23 | 2002-06-28 | Sankyo Company Ltd Chuo Ku | Spiropiperidine derivatives, medicaments containing them and their use |
MXPA01012694A (es) * | 1999-06-07 | 2003-10-15 | Warner Lambert Co | Analgesicos triciclicos. |
ATE264330T1 (de) * | 1999-07-21 | 2004-04-15 | Astrazeneca Ab | Verbindungen |
WO2002085354A1 (en) | 2001-04-18 | 2002-10-31 | Euro-Celtique S.A. | Spiroindene and spiroindane compounds |
SE0202133D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
AU2003284984B2 (en) * | 2002-10-30 | 2008-10-23 | Merck Sharp & Dohme Corp. | Gamma-aminoamide modulators of chemokine receptor activity |
JPWO2004092179A1 (ja) * | 2003-04-14 | 2006-07-06 | 日本曹達株式会社 | スピロ誘導体、製造法および抗酸化薬 |
TW200524868A (en) | 2003-07-31 | 2005-08-01 | Zeria Pharm Co Ltd | Benzylamine derivatives |
US7091211B2 (en) * | 2003-07-31 | 2006-08-15 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
NZ546834A (en) | 2003-10-01 | 2010-03-26 | Adolor Corp | Spirocyclic heterocyclic derivatives and methods of their use |
GB0328906D0 (en) | 2003-12-12 | 2004-01-14 | Syngenta Participations Ag | Chemical compounds |
US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7230022B2 (en) * | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
US7288563B2 (en) * | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7479496B2 (en) * | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
US7864913B2 (en) * | 2004-02-19 | 2011-01-04 | Kabushiki Kaisha Toshiba | Fast reactor having reflector control system and neutron reflector thereof |
AU2005214274A1 (en) | 2004-02-25 | 2005-09-01 | Sankyo Company, Limited | Indanol derivative |
JO2527B1 (en) * | 2004-04-06 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines |
JO2676B1 (en) * | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
ATE478075T1 (de) * | 2005-03-08 | 2010-09-15 | Janssen Pharmaceutica Nv | Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten |
US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
RU2422446C2 (ru) | 2005-07-19 | 2011-06-27 | Мерк Шарп Энд Домэ Корп. | Производные спирохроманона в качестве ингибиторов ацетил коэнзим а карбоксилазы (асс) |
US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
CA2648831A1 (en) * | 2006-05-05 | 2007-11-15 | Ulrich Reiser | Spiro- (tho) benzopyran-2, 4' -piperidine-and cyclohexane derivatives as inhibitors of specific cell cycle enzymes |
WO2008033299A2 (en) * | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of n-containing spirocompounds for the enhancement of cognitive function |
PE20081559A1 (es) | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
AU2008205642B2 (en) | 2007-01-12 | 2013-06-06 | Msd K.K. | Spirochromanon derivatives |
US8614324B2 (en) * | 2008-10-31 | 2013-12-24 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
US8653068B2 (en) | 2009-10-30 | 2014-02-18 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
US9340558B2 (en) | 2007-11-02 | 2016-05-17 | Pain Therapeutics Inc. | Filamin a binding anti-inflammatory and analgesic |
WO2009108332A1 (en) * | 2008-02-27 | 2009-09-03 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE TYPE 1 |
US8580808B2 (en) * | 2009-10-30 | 2013-11-12 | Pain Therapeutic, Inc. | Filamin A-binding anti-inflammatory analgesic |
WO2010051476A1 (en) * | 2008-10-31 | 2010-05-06 | Pain Therapeutics, Inc. | Filamin a-binding anti-inflammatory analgesic |
US8580809B2 (en) * | 2009-10-30 | 2013-11-12 | Pain Therapeutics, Inc. | Filamin A-binding anti-inflammatory analgesic |
WO2014011917A2 (en) | 2012-07-13 | 2014-01-16 | Pain Therapeutics, Inc. | A method of inhibiting tau phosphorylation |
US9433604B2 (en) | 2013-10-08 | 2016-09-06 | Pain Therapeutics Inc. | Method for inhibiting growth of cancer cells |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4166119A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines |
US4166120A (en) * | 1978-04-14 | 1979-08-28 | American Hoechst Corporation | Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines |
US4420485A (en) * | 1982-09-29 | 1983-12-13 | Hoechst-Roussel Pharmaceuticals Inc. | 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] |
US4452802A (en) * | 1983-08-25 | 1984-06-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Antihypertensive spiro[benzofuran-azalkanes] |
EP0311313B1 (de) * | 1987-10-05 | 1995-05-10 | Yamanouchi Pharmaceutical Co. Ltd. | Heterozyklische Spiroverbindungen und ihre Herstellung |
US5075317A (en) * | 1989-06-21 | 1991-12-24 | Fisons Corporation | Spirofurane derivatives |
FI97540C (fi) * | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
US5091387A (en) * | 1990-03-02 | 1992-02-25 | Merck & Co., Inc. | Spirocyclic oxytocin antagonists |
CA2037287A1 (en) * | 1990-03-02 | 1991-09-03 | Ben E. Evans | Spirocyclic oxytocin antagonists |
EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical preparations containing them |
-
1994
- 1994-01-25 JP JP6517241A patent/JPH08505880A/ja active Pending
- 1994-01-25 AT AT94907866T patent/ATE169001T1/de not_active IP Right Cessation
- 1994-01-25 DK DK94907866T patent/DK0681571T3/da active
- 1994-01-25 WO PCT/US1994/000819 patent/WO1994017045A1/en active IP Right Grant
- 1994-01-25 DE DE69412067T patent/DE69412067T2/de not_active Expired - Fee Related
- 1994-01-25 EP EP94907866A patent/EP0681571B1/de not_active Expired - Lifetime
- 1994-01-25 US US08/481,418 patent/US5869496A/en not_active Expired - Fee Related
- 1994-01-25 AU AU61268/94A patent/AU693087B2/en not_active Ceased
- 1994-01-25 CA CA002154569A patent/CA2154569A1/en not_active Abandoned
- 1994-01-25 ES ES94907866T patent/ES2119174T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1994017045A1 (en) | 1994-08-04 |
DK0681571T3 (da) | 1998-11-23 |
JPH08505880A (ja) | 1996-06-25 |
US5869496A (en) | 1999-02-09 |
AU6126894A (en) | 1994-08-15 |
EP0681571B1 (de) | 1998-07-29 |
ATE169001T1 (de) | 1998-08-15 |
DE69412067D1 (de) | 1998-09-03 |
EP0681571A1 (de) | 1995-11-15 |
ES2119174T3 (es) | 1998-10-01 |
AU693087B2 (en) | 1998-06-25 |
CA2154569A1 (en) | 1994-08-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |