DE69504198T2 - Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten - Google Patents

Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten

Info

Publication number
DE69504198T2
DE69504198T2 DE69504198T DE69504198T DE69504198T2 DE 69504198 T2 DE69504198 T2 DE 69504198T2 DE 69504198 T DE69504198 T DE 69504198T DE 69504198 T DE69504198 T DE 69504198T DE 69504198 T2 DE69504198 T2 DE 69504198T2
Authority
DE
Germany
Prior art keywords
substituted alkyl
diamine derivatives
alkyl diamine
tachykinin antagonists
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69504198T
Other languages
English (en)
Other versions
DE69504198D1 (de
Inventor
Timothy Burkholder
Elizabeth Kudlacz
Tieu-Binh Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69504198D1 publication Critical patent/DE69504198D1/de
Application granted granted Critical
Publication of DE69504198T2 publication Critical patent/DE69504198T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
DE69504198T 1994-06-20 1995-05-19 Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten Expired - Fee Related DE69504198T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/262,209 US5597845A (en) 1994-06-20 1994-06-20 Substituted alkyldiamine derivatives
PCT/US1995/006317 WO1995035279A1 (en) 1994-06-20 1995-05-19 Substituted alkyldiamine derivatives and their use as tachykinin antagonists

Publications (2)

Publication Number Publication Date
DE69504198D1 DE69504198D1 (de) 1998-09-24
DE69504198T2 true DE69504198T2 (de) 1999-04-29

Family

ID=22996631

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69504198T Expired - Fee Related DE69504198T2 (de) 1994-06-20 1995-05-19 Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten

Country Status (20)

Country Link
US (1) US5597845A (de)
EP (1) EP0767783B1 (de)
JP (1) JP3920916B2 (de)
KR (1) KR100371981B1 (de)
CN (1) CN1083429C (de)
AT (1) ATE169905T1 (de)
AU (1) AU691619B2 (de)
CA (1) CA2193348C (de)
DE (1) DE69504198T2 (de)
DK (1) DK0767783T3 (de)
ES (1) ES2121389T3 (de)
FI (1) FI115135B (de)
HU (1) HUT75965A (de)
IL (1) IL114185A (de)
MX (1) MX9606654A (de)
NO (1) NO307458B1 (de)
NZ (1) NZ287291A (de)
TW (1) TW442451B (de)
WO (1) WO1995035279A1 (de)
ZA (1) ZA954947B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW541295B (en) * 1999-01-05 2003-07-11 Nippon Zoki Pharmaceutical Co A novel substituted alkylteraamine derivative for use as tachykinin antagonist
US6613801B2 (en) * 2000-05-30 2003-09-02 Transtech Pharma, Inc. Method for the synthesis of compounds of formula I and their uses thereof
AU2002245591B2 (en) 2001-03-05 2007-05-17 Transtech Pharma, Inc. Carboxamide derivatives as therapeutic agents
WO2002069965A1 (en) 2001-03-05 2002-09-12 Transtech Pharma, Inc. Benzimidazole derivatives as therapeutic agents
EP1482931B1 (de) 2002-03-05 2011-10-19 TransTech Pharma, Inc. Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
US20090263370A1 (en) * 2006-11-30 2009-10-22 Guoliang Tao Methods for treating tachykinin-mediated diseases with cholinesterase
EP2470510B1 (de) 2009-09-30 2014-05-14 TransTech Pharma, LLC Substituierte imidazol-derivate für die behandlung von alzheimers krankheit.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
ES2153841T3 (es) * 1992-08-13 2001-03-16 Warner Lambert Co Antagonistas de la taciquinina.

Also Published As

Publication number Publication date
ES2121389T3 (es) 1998-11-16
JP3920916B2 (ja) 2007-05-30
NO965469L (no) 1997-02-19
AU691619B2 (en) 1998-05-21
HUT75965A (en) 1997-05-28
ATE169905T1 (de) 1998-09-15
FI115135B (fi) 2005-03-15
US5597845A (en) 1997-01-28
CA2193348A1 (en) 1995-12-28
NZ287291A (en) 1998-10-28
NO965469D0 (no) 1996-12-19
EP0767783A1 (de) 1997-04-16
IL114185A (en) 1999-07-14
ZA954947B (en) 1996-01-31
FI965097A0 (fi) 1996-12-18
WO1995035279A1 (en) 1995-12-28
DK0767783T3 (da) 1999-05-25
IL114185A0 (de) 1995-10-31
DE69504198D1 (de) 1998-09-24
JPH10501551A (ja) 1998-02-10
FI965097A (fi) 1996-12-18
MX9606654A (es) 1997-12-31
EP0767783B1 (de) 1998-08-19
AU2596195A (en) 1996-01-15
TW442451B (en) 2001-06-23
CA2193348C (en) 1999-08-24
CN1155883A (zh) 1997-07-30
NO307458B1 (no) 2000-04-10
HU9603540D0 (en) 1997-02-28
CN1083429C (zh) 2002-04-24
KR100371981B1 (ko) 2003-06-12

Similar Documents

Publication Publication Date Title
MX9707879A (es) Derivados de piperazina sustituidos novedosos que tienen actividad antagonista de receptor de taquinina.
BR9610277A (pt) Derivados de piperazino como antagonistas de neurowuinina
DE69616480T2 (de) Piperidinderivate als neurokininantagonisten
DE69725457D1 (de) Piperazinderivate als neurokinin-antagonisten
DE69629023D1 (de) Piperazino-derivative als neurokininantagonisten
BG105710A (en) 5ht1 antagonists for antidepressant therapy
DE69504198T2 (de) Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten
CA2269128A1 (en) Piperazino derivatives as neurokinin antagonists
TR199901395T2 (xx) Yeni karboksi ikameli siklik karboksamid t�revleri.
CA2215333A1 (en) Heterocyclic substituted piperazinone derivatives as tachykinin receptor antagonists
CA2275527A1 (en) Novel heterocyclic substituted pyrrolidine amide derivatives
ATE265418T1 (de) Neue substituierte 3-phenoxy- und 3- phenylalkyloxy-2-phenyl-propylamine
CA2329075A1 (en) Carboxy substituted carboxamide derivatives as tachykinin receptor antagonists

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR

8339 Ceased/non-payment of the annual fee