ATE169905T1 - Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten - Google Patents

Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten

Info

Publication number
ATE169905T1
ATE169905T1 AT95920539T AT95920539T ATE169905T1 AT E169905 T1 ATE169905 T1 AT E169905T1 AT 95920539 T AT95920539 T AT 95920539T AT 95920539 T AT95920539 T AT 95920539T AT E169905 T1 ATE169905 T1 AT E169905T1
Authority
AT
Austria
Prior art keywords
antagonists
derivatives
tachykine
alkyldiminine
substituted
Prior art date
Application number
AT95920539T
Other languages
English (en)
Inventor
Timothy P Burkholder
Elizabeth Kudlacz
Tieu-Binh Le
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE169905T1 publication Critical patent/ATE169905T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT95920539T 1994-06-20 1995-05-19 Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten ATE169905T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/262,209 US5597845A (en) 1994-06-20 1994-06-20 Substituted alkyldiamine derivatives

Publications (1)

Publication Number Publication Date
ATE169905T1 true ATE169905T1 (de) 1998-09-15

Family

ID=22996631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920539T ATE169905T1 (de) 1994-06-20 1995-05-19 Substituierte alkyldiaminderivate und ihre verwendung als tachykinin antagonisten

Country Status (20)

Country Link
US (1) US5597845A (de)
EP (1) EP0767783B1 (de)
JP (1) JP3920916B2 (de)
KR (1) KR100371981B1 (de)
CN (1) CN1083429C (de)
AT (1) ATE169905T1 (de)
AU (1) AU691619B2 (de)
CA (1) CA2193348C (de)
DE (1) DE69504198T2 (de)
DK (1) DK0767783T3 (de)
ES (1) ES2121389T3 (de)
FI (1) FI115135B (de)
HU (1) HUT75965A (de)
IL (1) IL114185A (de)
MX (1) MX9606654A (de)
NO (1) NO307458B1 (de)
NZ (1) NZ287291A (de)
TW (1) TW442451B (de)
WO (1) WO1995035279A1 (de)
ZA (1) ZA954947B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW541295B (en) * 1999-01-05 2003-07-11 Nippon Zoki Pharmaceutical Co A novel substituted alkylteraamine derivative for use as tachykinin antagonist
US6613801B2 (en) * 2000-05-30 2003-09-02 Transtech Pharma, Inc. Method for the synthesis of compounds of formula I and their uses thereof
AU2002245591B2 (en) 2001-03-05 2007-05-17 Transtech Pharma, Inc. Carboxamide derivatives as therapeutic agents
WO2002069965A1 (en) 2001-03-05 2002-09-12 Transtech Pharma, Inc. Benzimidazole derivatives as therapeutic agents
EP1482931B1 (de) 2002-03-05 2011-10-19 TransTech Pharma, Inc. Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
US20090263370A1 (en) * 2006-11-30 2009-10-22 Guoliang Tao Methods for treating tachykinin-mediated diseases with cholinesterase
EP2470510B1 (de) 2009-09-30 2014-05-14 TransTech Pharma, LLC Substituierte imidazol-derivate für die behandlung von alzheimers krankheit.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
US5472978A (en) * 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
ES2153841T3 (es) * 1992-08-13 2001-03-16 Warner Lambert Co Antagonistas de la taciquinina.

Also Published As

Publication number Publication date
ES2121389T3 (es) 1998-11-16
JP3920916B2 (ja) 2007-05-30
NO965469L (no) 1997-02-19
AU691619B2 (en) 1998-05-21
HUT75965A (en) 1997-05-28
FI115135B (fi) 2005-03-15
US5597845A (en) 1997-01-28
CA2193348A1 (en) 1995-12-28
NZ287291A (en) 1998-10-28
NO965469D0 (no) 1996-12-19
EP0767783A1 (de) 1997-04-16
IL114185A (en) 1999-07-14
ZA954947B (en) 1996-01-31
FI965097A0 (fi) 1996-12-18
WO1995035279A1 (en) 1995-12-28
DK0767783T3 (da) 1999-05-25
IL114185A0 (de) 1995-10-31
DE69504198D1 (de) 1998-09-24
JPH10501551A (ja) 1998-02-10
FI965097A (fi) 1996-12-18
MX9606654A (es) 1997-12-31
DE69504198T2 (de) 1999-04-29
EP0767783B1 (de) 1998-08-19
AU2596195A (en) 1996-01-15
TW442451B (en) 2001-06-23
CA2193348C (en) 1999-08-24
CN1155883A (zh) 1997-07-30
NO307458B1 (no) 2000-04-10
HU9603540D0 (en) 1997-02-28
CN1083429C (zh) 2002-04-24
KR100371981B1 (ko) 2003-06-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee