FI965097A0 - Substituoidut alkyylidiamiinijohdannaiset ja niiden käyttö takykiniini antagonisteina - Google Patents

Substituoidut alkyylidiamiinijohdannaiset ja niiden käyttö takykiniini antagonisteina

Info

Publication number
FI965097A0
FI965097A0 FI965097A FI965097A FI965097A0 FI 965097 A0 FI965097 A0 FI 965097A0 FI 965097 A FI965097 A FI 965097A FI 965097 A FI965097 A FI 965097A FI 965097 A0 FI965097 A0 FI 965097A0
Authority
FI
Finland
Prior art keywords
substituted alkyl
diamine derivatives
alkyl diamine
tachykinin antagonists
antagonists
Prior art date
Application number
FI965097A
Other languages
English (en)
Swedish (sv)
Other versions
FI115135B (fi
FI965097A (fi
Inventor
Timothy P Burkholder
Elizabeth Kudlacz
Tieu-Binh Le
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI965097A publication Critical patent/FI965097A/fi
Publication of FI965097A0 publication Critical patent/FI965097A0/fi
Application granted granted Critical
Publication of FI115135B publication Critical patent/FI115135B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI965097A 1994-06-20 1996-12-18 Substituoidut alkyylidiamiinijohdannaiset ja niiden käyttö takykiniinin antagonisteina FI115135B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/262,209 US5597845A (en) 1994-06-20 1994-06-20 Substituted alkyldiamine derivatives
US26220994 1994-06-20
US9506317 1995-05-19
PCT/US1995/006317 WO1995035279A1 (en) 1994-06-20 1995-05-19 Substituted alkyldiamine derivatives and their use as tachykinin antagonists

Publications (3)

Publication Number Publication Date
FI965097A FI965097A (fi) 1996-12-18
FI965097A0 true FI965097A0 (fi) 1996-12-18
FI115135B FI115135B (fi) 2005-03-15

Family

ID=22996631

Family Applications (1)

Application Number Title Priority Date Filing Date
FI965097A FI115135B (fi) 1994-06-20 1996-12-18 Substituoidut alkyylidiamiinijohdannaiset ja niiden käyttö takykiniinin antagonisteina

Country Status (20)

Country Link
US (1) US5597845A (fi)
EP (1) EP0767783B1 (fi)
JP (1) JP3920916B2 (fi)
KR (1) KR100371981B1 (fi)
CN (1) CN1083429C (fi)
AT (1) ATE169905T1 (fi)
AU (1) AU691619B2 (fi)
CA (1) CA2193348C (fi)
DE (1) DE69504198T2 (fi)
DK (1) DK0767783T3 (fi)
ES (1) ES2121389T3 (fi)
FI (1) FI115135B (fi)
HU (1) HUT75965A (fi)
IL (1) IL114185A (fi)
MX (1) MX9606654A (fi)
NO (1) NO307458B1 (fi)
NZ (1) NZ287291A (fi)
TW (1) TW442451B (fi)
WO (1) WO1995035279A1 (fi)
ZA (1) ZA954947B (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW541295B (en) * 1999-01-05 2003-07-11 Nippon Zoki Pharmaceutical Co A novel substituted alkylteraamine derivative for use as tachykinin antagonist
US6613801B2 (en) * 2000-05-30 2003-09-02 Transtech Pharma, Inc. Method for the synthesis of compounds of formula I and their uses thereof
CA2440042C (en) 2001-03-05 2011-09-27 Transtech Pharma, Inc. Carboxamide derivatives as therapeutic agents
JP2004523565A (ja) 2001-03-05 2004-08-05 トランス　テック　ファーマ，インコーポレイテッド 治療因子としてのベンゾイミダゾール誘導体
CN101613321A (zh) 2002-03-05 2009-12-30 特兰斯泰克制药公司 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物
US20090263370A1 (en) * 2006-11-30 2009-10-22 Guoliang Tao Methods for treating tachykinin-mediated diseases with cholinesterase
WO2011041198A1 (en) 2009-09-30 2011-04-07 Transtech Pharma, Inc. Substituted imidazole derivatives for treatment of alzheimers disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164372A (en) * 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
EP0593559A1 (en) * 1991-07-05 1994-04-27 MERCK SHARP & DOHME LTD. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
EP1000930A3 (en) * 1992-08-13 2003-10-29 Warner-Lambert Company Tachykinin antagonists

Also Published As

Publication number Publication date
ES2121389T3 (es) 1998-11-16
FI115135B (fi) 2005-03-15
TW442451B (en) 2001-06-23
KR100371981B1 (ko) 2003-06-12
ATE169905T1 (de) 1998-09-15
JP3920916B2 (ja) 2007-05-30
JPH10501551A (ja) 1998-02-10
CA2193348C (en) 1999-08-24
MX9606654A (es) 1997-12-31
FI965097A (fi) 1996-12-18
CN1155883A (zh) 1997-07-30
HUT75965A (en) 1997-05-28
EP0767783B1 (en) 1998-08-19
ZA954947B (en) 1996-01-31
DE69504198D1 (de) 1998-09-24
CA2193348A1 (en) 1995-12-28
AU691619B2 (en) 1998-05-21
DE69504198T2 (de) 1999-04-29
NO965469D0 (no) 1996-12-19
IL114185A0 (fi) 1995-10-31
WO1995035279A1 (en) 1995-12-28
NO307458B1 (no) 2000-04-10
NZ287291A (en) 1998-10-28
AU2596195A (en) 1996-01-15
CN1083429C (zh) 2002-04-24
EP0767783A1 (en) 1997-04-16
NO965469L (no) 1997-02-19
DK0767783T3 (da) 1999-05-25
IL114185A (en) 1999-07-14
US5597845A (en) 1997-01-28
HU9603540D0 (en) 1997-02-28

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