DE3781173T2 - N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen. - Google Patents

N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen.

Info

Publication number
DE3781173T2
DE3781173T2 DE8787200128T DE3781173T DE3781173T2 DE 3781173 T2 DE3781173 T2 DE 3781173T2 DE 8787200128 T DE8787200128 T DE 8787200128T DE 3781173 T DE3781173 T DE 3781173T DE 3781173 T2 DE3781173 T2 DE 3781173T2
Authority
DE
Germany
Prior art keywords
alkyl
substd
alkoxy
furanyl
opt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787200128T
Other languages
English (en)
Other versions
DE3781173D1 (de
Inventor
Frans E Janssens
Jozef F Hens
Joseph L G Torremans
Jozef J P Heykants
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE3781173D1 publication Critical patent/DE3781173D1/de
Publication of DE3781173T2 publication Critical patent/DE3781173T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
DE8787200128T 1986-02-03 1987-01-28 N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen. Expired - Lifetime DE3781173T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82549186A 1986-02-03 1986-02-03

Publications (2)

Publication Number Publication Date
DE3781173D1 DE3781173D1 (de) 1992-09-24
DE3781173T2 true DE3781173T2 (de) 1992-12-17

Family

ID=25244134

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787200128T Expired - Lifetime DE3781173T2 (de) 1986-02-03 1987-01-28 N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen.

Country Status (26)

Country Link
EP (1) EP0232937B1 (de)
JP (2) JPH0794393B2 (de)
CN (1) CN1018614B (de)
AT (1) ATE79620T1 (de)
AU (1) AU583706B2 (de)
CA (1) CA1327579C (de)
CY (1) CY1865A (de)
DE (1) DE3781173T2 (de)
DK (1) DK173674B1 (de)
EG (1) EG17993A (de)
ES (1) ES2052544T3 (de)
FI (1) FI870448A (de)
GR (1) GR3006158T3 (de)
HK (1) HK114695A (de)
HU (1) HU201067B (de)
IE (1) IE60885B1 (de)
IL (1) IL81448A (de)
MA (1) MA20868A1 (de)
NO (1) NO870407L (de)
NZ (1) NZ219165A (de)
PH (1) PH24738A (de)
PT (1) PT84234B (de)
TN (1) TNSN87015A1 (de)
ZA (1) ZA87744B (de)
ZM (1) ZM1287A1 (de)
ZW (1) ZW2087A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
IT1229231B (it) * 1989-05-08 1991-07-26 Dompe Farmaceutici Spa Aminoimidazopiridine farmacologicamente attive
CA2043564A1 (en) * 1990-07-06 1992-01-07 Alfons G. M. De Knaep 3-[(5-methyl-2-furanyl)methyl]-n-(4-piperidinyl)-3h-imidazo [4,5-b]-pyridin-2-amine 2-hydroxy-1,2,3-propanetricarboxylate
NZ239540A (en) * 1990-09-24 1993-11-25 Neurosearch As 1-phenyl benzimidazole derivatives and medicaments
DK0920865T3 (da) * 1992-09-03 2004-04-19 Sepracor Inc Farmaceutiske sammensætninger indeholdende norastemizol
AU730229B2 (en) * 1992-09-03 2001-03-01 Sepracor, Inc. Use of norastemizole for the treatment of allergic disorders
US5624948A (en) * 1993-05-20 1997-04-29 Kissei Pharmaceutical Co., Ltd. 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds
TW429256B (en) * 1995-12-27 2001-04-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
WO1998042379A2 (en) * 1997-03-26 1998-10-01 Sepracor Inc. Chemically and thermally stable norastemizole formulations
US5817823A (en) * 1997-04-17 1998-10-06 Sepracor Inc. Method for synthesizing 2-substituted imidazoles
CN1210275C (zh) 1999-06-28 2005-07-13 詹森药业有限公司 呼吸道合胞病毒复制抑制剂
SI1196408T1 (en) 1999-06-28 2005-02-28 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
AU774829B2 (en) 1999-06-28 2004-07-08 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
EP1638939A2 (de) * 2003-06-24 2006-03-29 Neurosearch A/S Derivative mit aza-ring und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern
US20050222198A1 (en) 2003-12-22 2005-10-06 K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
CA2592388C (en) 2004-12-21 2013-04-02 Steven S. Bondy Imidazo[4,5-c]pyridine compound and method of antiviral treatment
JP5065908B2 (ja) * 2004-12-24 2012-11-07 プロシディオン・リミテッド Ｇタンパク質結合受容体作動薬
DE602006016244D1 (de) 2005-03-08 2010-09-30 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin-(nk1)-antagonisten
DK2038275T3 (da) 2006-07-07 2010-05-10 Gilead Sciences Inc Ny pyridazinforbindelse og anvendelse heraf
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
WO2010036613A1 (en) * 2008-09-26 2010-04-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219559A (en) 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
IN156065B (de) * 1982-07-12 1985-05-04 Janssen Pharmaceutica Nv
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
DE3484096D1 (de) * 1983-11-30 1991-03-14 Janssen Pharmaceutica Nv Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
PL144514B1 (en) * 1984-01-09 1988-06-30 Janssen Pharmaceutica Nv Method of obtaining novel derivatives of n-/4-piperidinolo/-2-imidazoloamine

Also Published As

Publication number Publication date
NO870407D0 (no) 1987-02-02
AU583706B2 (en) 1989-05-04
IE60885B1 (en) 1994-08-24
TNSN87015A1 (fr) 1990-01-01
PT84234B (pt) 1989-09-14
IL81448A0 (en) 1987-09-16
GR3006158T3 (de) 1993-06-21
ATE79620T1 (de) 1992-09-15
DK54187D0 (da) 1987-02-02
ZW2087A1 (en) 1988-08-31
ZM1287A1 (en) 1988-08-29
HUT44544A (en) 1988-03-28
HU201067B (en) 1990-09-28
PH24738A (en) 1990-10-01
CN87100563A (zh) 1987-08-19
JPH07179458A (ja) 1995-07-18
MA20868A1 (fr) 1987-10-01
JPS62215575A (ja) 1987-09-22
AU6821887A (en) 1987-08-06
NO870407L (no) 1987-08-04
EG17993A (en) 1991-08-30
JPH0819126B2 (ja) 1996-02-28
EP0232937A3 (en) 1988-04-06
EP0232937A2 (de) 1987-08-19
ZA87744B (en) 1988-10-26
FI870448A0 (fi) 1987-02-02
IL81448A (en) 1990-09-17
CN1018614B (zh) 1992-10-14
ES2052544T3 (es) 1994-07-16
NZ219165A (en) 1990-04-26
IE870258L (en) 1987-08-03
HK114695A (en) 1995-07-21
DE3781173D1 (de) 1992-09-24
DK54187A (da) 1987-08-04
DK173674B1 (da) 2001-06-05
CY1865A (en) 1996-04-05
FI870448A (fi) 1987-08-04
EP0232937B1 (de) 1992-08-19
CA1327579C (en) 1994-03-08
JPH0794393B2 (ja) 1995-10-11
PT84234A (en) 1987-03-01

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