ATE79620T1 - N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen. - Google Patents
N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen.Info
- Publication number
- ATE79620T1 ATE79620T1 AT87200128T AT87200128T ATE79620T1 AT E79620 T1 ATE79620 T1 AT E79620T1 AT 87200128 T AT87200128 T AT 87200128T AT 87200128 T AT87200128 T AT 87200128T AT E79620 T1 ATE79620 T1 AT E79620T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- substd
- alkoxy
- furanyl
- opt
- Prior art date
Links
- 230000001387 anti-histamine Effects 0.000 title 1
- 239000000739 antihistaminic agent Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- -1 1-6C alkyl-furanyl Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- CLPYDQPFQYNIDH-UHFFFAOYSA-N n-piperidin-4-yl-1h-benzimidazol-2-amine Chemical compound C1CNCCC1NC1=NC2=CC=CC=C2N1 CLPYDQPFQYNIDH-UHFFFAOYSA-N 0.000 abstract 1
- GJSYDLQEDRMJPU-UHFFFAOYSA-N n-piperidin-4-yl-1h-imidazo[4,5-b]pyridin-2-amine Chemical compound C1CNCCC1NC1=NC2=CC=CN=C2N1 GJSYDLQEDRMJPU-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82549186A | 1986-02-03 | 1986-02-03 | |
| EP87200128A EP0232937B1 (de) | 1986-02-03 | 1987-01-28 | N-Heterozyklische-4-piperidinamine enthaltende anti-histaminische Zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE79620T1 true ATE79620T1 (de) | 1992-09-15 |
Family
ID=25244134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87200128T ATE79620T1 (de) | 1986-02-03 | 1987-01-28 | N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen. |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0232937B1 (de) |
| JP (2) | JPH0794393B2 (de) |
| CN (1) | CN1018614B (de) |
| AT (1) | ATE79620T1 (de) |
| AU (1) | AU583706B2 (de) |
| CA (1) | CA1327579C (de) |
| CY (1) | CY1865A (de) |
| DE (1) | DE3781173T2 (de) |
| DK (1) | DK173674B1 (de) |
| EG (1) | EG17993A (de) |
| ES (1) | ES2052544T3 (de) |
| FI (1) | FI870448A7 (de) |
| GR (1) | GR3006158T3 (de) |
| HK (1) | HK114695A (de) |
| HU (1) | HU201067B (de) |
| IE (1) | IE60885B1 (de) |
| IL (1) | IL81448A (de) |
| MA (1) | MA20868A1 (de) |
| NO (1) | NO870407L (de) |
| NZ (1) | NZ219165A (de) |
| PH (1) | PH24738A (de) |
| PT (1) | PT84234B (de) |
| TN (1) | TNSN87015A1 (de) |
| ZA (1) | ZA87744B (de) |
| ZM (1) | ZM1287A1 (de) |
| ZW (1) | ZW2087A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ223654A (en) * | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
| US4897401A (en) * | 1987-06-19 | 1990-01-30 | Janssen Pharmaceutical N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases |
| US4988689A (en) * | 1987-07-01 | 1991-01-29 | Janssen Pharmaceutica N.V. | ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines |
| CA1317939C (en) * | 1987-07-01 | 1993-05-18 | Janssen Pharmaceutica Naamloze Vennootschap | ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines |
| PH30434A (en) * | 1989-04-07 | 1997-05-09 | Janssen Pharmaceutica Nv | Hydroxyalkylfuranyl derivatives |
| IT1229231B (it) * | 1989-05-08 | 1991-07-26 | Dompe Farmaceutici Spa | Aminoimidazopiridine farmacologicamente attive |
| CA2043564A1 (en) * | 1990-07-06 | 1992-01-07 | Alfons G. M. De Knaep | 3-[(5-methyl-2-furanyl)methyl]-n-(4-piperidinyl)-3h-imidazo [4,5-b]-pyridin-2-amine 2-hydroxy-1,2,3-propanetricarboxylate |
| NZ239540A (en) * | 1990-09-24 | 1993-11-25 | Neurosearch As | 1-phenyl benzimidazole derivatives and medicaments |
| AU730229B2 (en) * | 1992-09-03 | 2001-03-01 | Sepracor, Inc. | Use of norastemizole for the treatment of allergic disorders |
| DE69327328T2 (de) * | 1992-09-03 | 2000-06-21 | Sepracor Inc., Marlborough | Verwendund von norastemizol zur behandlung der allergischen rhinitis |
| FI955523A0 (fi) * | 1993-05-20 | 1995-11-16 | Kissei Pharmaceutical | 1-(2-bentsimidatsolyyli)-1,5-diatsasyklo-oksataaniyhdisteet |
| TW429256B (en) * | 1995-12-27 | 2001-04-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives |
| CA2284705A1 (en) * | 1997-03-26 | 1998-10-01 | Sepracor Inc. | Chemically and thermally stable norastemizole formulations |
| US5817823A (en) * | 1997-04-17 | 1998-10-06 | Sepracor Inc. | Method for synthesizing 2-substituted imidazoles |
| EP1196408B1 (de) | 1999-06-28 | 2004-09-15 | Janssen Pharmaceutica N.V. | Replikationsinhibitoren des respiratorischen synzytialvirus |
| ATE258928T1 (de) | 1999-06-28 | 2004-02-15 | Janssen Pharmaceutica Nv | Respiratorisches syncytialvirus replikation inhibitoren |
| HUP0201789A3 (en) | 1999-06-28 | 2003-12-29 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| EP1638939A2 (de) * | 2003-06-24 | 2006-03-29 | Neurosearch A/S | Derivative mit aza-ring und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern |
| PT1706403E (pt) | 2003-12-22 | 2012-04-23 | Gilead Sciences Inc | Compostos de imidazo[4,5-c]piridina e métodos de tratamento antiviral |
| DK1841765T5 (da) | 2004-12-21 | 2009-12-21 | Gilead Sciences Inc | Imidazo[4,5-C]pyridinforbindelse og fremgangsmåde til antiviral behandling |
| US8193359B2 (en) | 2004-12-24 | 2012-06-05 | Prosidion Limited | G-protein coupled receptor agonists |
| CN101137657B (zh) | 2005-03-08 | 2011-02-02 | 詹森药业有限公司 | 作为神经激肽（nk1）拮抗剂的二氮杂-螺-[4.4]-壬烷衍生物 |
| HRP20090078A2 (en) | 2006-07-07 | 2009-06-30 | Gilead Sciences | Novel pyridazine compound and use thereof |
| UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
| US8394969B2 (en) * | 2008-09-26 | 2013-03-12 | Merck Sharp & Dohme Corp. | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219559A (en) * | 1979-01-10 | 1980-08-26 | Janssen Pharmaceutica N.V. | N-Heterocyclyl-4-piperidinamines |
| CA1140119A (en) * | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
| US4556660A (en) * | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
| IN156065B (de) * | 1982-07-12 | 1985-05-04 | Janssen Pharmaceutica Nv | |
| US4634704A (en) * | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
| EP0144101B1 (de) * | 1983-11-30 | 1991-02-06 | Janssen Pharmaceutica N.V. | Bizyklisches Heterozyklyl aufveisende N-(bizyklisches Heterozyklyl-4-piperidinamine |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| PL144514B1 (en) * | 1984-01-09 | 1988-06-30 | Janssen Pharmaceutica Nv | Method of obtaining novel derivatives of n-/4-piperidinolo/-2-imidazoloamine |
| US4588722A (en) * | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
-
1987
- 1987-01-28 AT AT87200128T patent/ATE79620T1/de not_active IP Right Cessation
- 1987-01-28 DE DE8787200128T patent/DE3781173T2/de not_active Expired - Lifetime
- 1987-01-28 EG EG48/87A patent/EG17993A/xx active
- 1987-01-28 CA CA000528342A patent/CA1327579C/en not_active Expired - Lifetime
- 1987-01-28 EP EP87200128A patent/EP0232937B1/de not_active Expired - Lifetime
- 1987-01-28 ES ES87200128T patent/ES2052544T3/es not_active Expired - Lifetime
- 1987-01-30 PH PH34794A patent/PH24738A/en unknown
- 1987-02-02 PT PT84234A patent/PT84234B/pt unknown
- 1987-02-02 ZW ZW20/87A patent/ZW2087A1/xx unknown
- 1987-02-02 FI FI870448A patent/FI870448A7/fi not_active Application Discontinuation
- 1987-02-02 NO NO870407A patent/NO870407L/no unknown
- 1987-02-02 DK DK198700541A patent/DK173674B1/da not_active IP Right Cessation
- 1987-02-02 IE IE25887A patent/IE60885B1/en not_active IP Right Cessation
- 1987-02-02 HU HU87354A patent/HU201067B/hu unknown
- 1987-02-02 IL IL81448A patent/IL81448A/xx not_active IP Right Cessation
- 1987-02-02 AU AU68218/87A patent/AU583706B2/en not_active Expired
- 1987-02-02 ZM ZM12/87A patent/ZM1287A1/xx unknown
- 1987-02-02 MA MA21102A patent/MA20868A1/fr unknown
- 1987-02-02 JP JP62020600A patent/JPH0794393B2/ja not_active Expired - Lifetime
- 1987-02-02 ZA ZA87744A patent/ZA87744B/xx unknown
- 1987-02-03 CN CN87100563A patent/CN1018614B/zh not_active Expired
- 1987-02-03 TN TNTNSN87015A patent/TNSN87015A1/fr unknown
- 1987-02-04 NZ NZ219165A patent/NZ219165A/en unknown
-
1992
- 1992-11-05 GR GR920402478T patent/GR3006158T3/el unknown
-
1994
- 1994-10-03 JP JP6260917A patent/JPH0819126B2/ja not_active Expired - Lifetime
-
1995
- 1995-07-13 HK HK114695A patent/HK114695A/en not_active IP Right Cessation
-
1996
- 1996-04-05 CY CY186596A patent/CY1865A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |