HUP9903405A1 - Metalloproteináz-inhibitor hatású ciklusos és heterociklusos N-szubsztituált-alfa- imino-hidroxámsavak, és -karbonsavak, előállításuk és alkalmazásuk - Google Patents

Metalloproteináz-inhibitor hatású ciklusos és heterociklusos N-szubsztituált-alfa- imino-hidroxámsavak, és -karbonsavak, előállításuk és alkalmazásuk

Info

Publication number
HUP9903405A1
HUP9903405A1 HU9903405A HUP9903405A HUP9903405A1 HU P9903405 A1 HUP9903405 A1 HU P9903405A1 HU 9903405 A HU9903405 A HU 9903405A HU P9903405 A HUP9903405 A HU P9903405A HU P9903405 A1 HUP9903405 A1 HU P9903405A1
Authority
HU
Hungary
Prior art keywords
powder
iminohydroxamic
heterocyclic
cyclic
preparation
Prior art date
Application number
HU9903405A
Other languages
English (en)
Inventor
Eckart Bartnik
Burkhard Haase
Manfred Schudok
Wilfried Schwab
Werner Thorwart
Klaus-Ulrich Weithmann
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26020318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9903405(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE1995142189 external-priority patent/DE19542189A1/de
Priority claimed from DE1996112298 external-priority patent/DE19612298A1/de
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of HUP9903405A1 publication Critical patent/HUP9903405A1/hu
Publication of HUP9903405A3 publication Critical patent/HUP9903405A3/hu
Publication of HU223086B1 publication Critical patent/HU223086B1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

A találmány szerinti vegyületek (I) általánős képletében R4 jelentése adőtt esetben szűbsztitűált naftilcsőpőrt, -B-C6H4-X-R2,-B-C6H4-Z vagy -B-Z1 általánős képletű csőpőrt, ahől B jelentésekővalens kötés vagy alkilén- vagy viniléncsőpőrt, C6H4feniléncsőpőrtőt jelent, X jelentése kővalens kötés, őxigénatőm,karbőnil-, hidrőxi-metilén-csőpőrt vagy -S(O)p-képletű csőpőrt, ahől pértéke 0, 1 vagy 2, R2 jelentése adőtt esetben szűbsztitűáltfenilcsőpőrt, Z és Z1 - jelentése egymástól függetlenül, - adőttesetben szűbsztitűált heterőciklűsős csőpőrt, A jelentése hidrőxi-aminő-karbőnil- vagy karbőxilcsőpőrt, Q jelentése adőtt esetben szűbsztitűált fenilén-, tienilén-,pirrőlilén- vagy imidazőliléncsőpőrt, m és n értéke 0, 1 vagy 2, bizőnyős feltételekkel. (I) ŕ
HU9903405A 1995-11-13 1996-11-04 Metalloproteináz-inhibitor hatású ciklusos és heterociklusos N-szubsztituált-alfa-imino-hidroxámsavak és karbonsavak, előállításuk és alkalmazásuk HU223086B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1995142189 DE19542189A1 (de) 1995-11-13 1995-11-13 Cyclische N-substituierte alpha-Iminohydroxamsäuren
DE1996112298 DE19612298A1 (de) 1996-03-28 1996-03-28 Heterocyclische N-substituierte alpha-Iminohydroxamsäuren
PCT/EP1996/004776 WO1997018194A1 (de) 1995-11-13 1996-11-04 CYCLISCHE UND HETEROCYCLISCHE N-SUBSTITUIERTE α-IMINOHYDROXAM- UND CARBONSÄUREN

Publications (3)

Publication Number Publication Date
HUP9903405A1 true HUP9903405A1 (hu) 2000-04-28
HUP9903405A3 HUP9903405A3 (en) 2000-12-28
HU223086B1 HU223086B1 (hu) 2004-03-29

Family

ID=26020318

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903405A HU223086B1 (hu) 1995-11-13 1996-11-04 Metalloproteináz-inhibitor hatású ciklusos és heterociklusos N-szubsztituált-alfa-imino-hidroxámsavak és karbonsavak, előállításuk és alkalmazásuk

Country Status (20)

Country Link
US (3) US6207672B1 (hu)
EP (1) EP0861236B2 (hu)
JP (1) JP4638560B2 (hu)
KR (1) KR100475206B1 (hu)
CN (1) CN1131215C (hu)
AT (1) ATE213232T1 (hu)
AU (1) AU707707B2 (hu)
BR (1) BR9611479B1 (hu)
CA (1) CA2237590C (hu)
CZ (1) CZ297550B6 (hu)
DE (1) DE59608740D1 (hu)
DK (1) DK0861236T4 (hu)
ES (1) ES2170884T5 (hu)
HU (1) HU223086B1 (hu)
MX (1) MX9803753A (hu)
PL (1) PL186869B1 (hu)
PT (1) PT861236E (hu)
RU (1) RU2164914C2 (hu)
TR (1) TR199800849T2 (hu)
WO (1) WO1997018194A1 (hu)

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BR9611479A (pt) 1999-07-13
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CN1202156A (zh) 1998-12-16
KR19990067685A (ko) 1999-08-25
CN1131215C (zh) 2003-12-17
CZ297550B6 (cs) 2007-02-07
EP0861236B2 (de) 2006-08-16
DK0861236T3 (da) 2002-05-21
EP0861236B1 (de) 2002-02-13
HU223086B1 (hu) 2004-03-29
HUP9903405A3 (en) 2000-12-28
AU7562496A (en) 1997-06-05
JP2000500145A (ja) 2000-01-11
ES2170884T5 (es) 2007-04-01
EP0861236A1 (de) 1998-09-02
TR199800849T2 (xx) 1998-07-21
BR9611479B1 (pt) 2009-01-13
MX9803753A (es) 1998-10-31
ATE213232T1 (de) 2002-02-15
CA2237590C (en) 2011-07-19
KR100475206B1 (ko) 2005-12-16
US6207672B1 (en) 2001-03-27
DE59608740D1 (de) 2002-03-21
CA2237590A1 (en) 1997-05-22
PT861236E (pt) 2002-07-31
DK0861236T4 (da) 2006-12-18
AU707707B2 (en) 1999-07-15
US6815440B2 (en) 2004-11-09
US20030176432A1 (en) 2003-09-18
JP4638560B2 (ja) 2011-02-23
WO1997018194A1 (de) 1997-05-22
ES2170884T3 (es) 2002-08-16
PL186869B1 (pl) 2004-03-31
PL326702A1 (en) 1998-10-26
US6573277B2 (en) 2003-06-03
CZ145398A3 (cs) 1998-08-12

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