ATE168685T1 - Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittel - Google Patents
Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittelInfo
- Publication number
- ATE168685T1 ATE168685T1 AT95932128T AT95932128T ATE168685T1 AT E168685 T1 ATE168685 T1 AT E168685T1 AT 95932128 T AT95932128 T AT 95932128T AT 95932128 T AT95932128 T AT 95932128T AT E168685 T1 ATE168685 T1 AT E168685T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- antithrbotic
- anticoagulant agents
- formula
- alkylene
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 3
- 229940127090 anticoagulant agent Drugs 0.000 title abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 102100024854 Taste receptor type 2 member 4 Human genes 0.000 abstract 1
- 108050000632 Taste receptor type 2 member 4 Proteins 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9419341A GB9419341D0 (en) | 1994-09-26 | 1994-09-26 | Aminoheterocyclic derivatives |
| GBGB9425789.6A GB9425789D0 (en) | 1994-12-21 | 1994-12-21 | Aminoheterocyclic derivatives |
| GBGB9511051.6A GB9511051D0 (en) | 1995-06-01 | 1995-06-01 | Aminoheterocyclic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE168685T1 true ATE168685T1 (de) | 1998-08-15 |
Family
ID=27267394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95932128T ATE168685T1 (de) | 1994-09-26 | 1995-09-25 | Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittel |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US5965559A (de) |
| EP (1) | EP0783500B1 (de) |
| JP (1) | JPH10506122A (de) |
| AT (1) | ATE168685T1 (de) |
| AU (1) | AU696491B2 (de) |
| BR (1) | BR9509045A (de) |
| CA (1) | CA2197471A1 (de) |
| CZ (1) | CZ285370B6 (de) |
| DE (1) | DE69503647T2 (de) |
| DK (1) | DK0783500T3 (de) |
| ES (1) | ES2119472T3 (de) |
| HU (1) | HUT77769A (de) |
| IL (1) | IL115420A0 (de) |
| NO (1) | NO971415L (de) |
| NZ (1) | NZ292983A (de) |
| PL (1) | PL319430A1 (de) |
| SK (1) | SK38597A3 (de) |
| WO (1) | WO1996010022A1 (de) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
| EE9700141A (et) * | 1994-12-23 | 1997-12-15 | Dr. Karl Thomae Gmbh | Piperasiinderivaadid, neid sisaldavad ravimid, nende kasutamine ja valmistamise meetod |
| ES2208737T3 (es) | 1995-03-10 | 2004-06-16 | Berlex Laboratories, Inc. | Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes. |
| GB9516709D0 (en) * | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| EP0880501A1 (de) | 1996-02-02 | 1998-12-02 | Zeneca Limited | Heterocyclische verbindungen verwendbar als pharmazeutische mittel |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| GB9602294D0 (en) * | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
| US5994375A (en) * | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| KR20000029984A (ko) * | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | 치환된피리미딘유도체및이의약학적용도 |
| US5753635A (en) * | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
| US5693641A (en) * | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
| US6008234A (en) * | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
| CN1234798A (zh) | 1996-09-12 | 1999-11-10 | 舍林股份公司 | 环状氨基酸和环状羟基羧酸衍生物取代的苄脒衍生物和它们用作抗凝剂的用途 |
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| EP0966462B1 (de) * | 1997-02-13 | 2003-06-11 | AstraZeneca AB | Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren anwendung finden |
| US6440972B1 (en) | 1997-02-13 | 2002-08-27 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
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| GB9715892D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| GB9715894D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
| GB9715895D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| DE69833036T2 (de) | 1997-09-30 | 2006-06-22 | Daiichi Pharmaceutical Co., Ltd. | Sulfonylderivate |
| US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
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| DK1040108T3 (da) | 1997-12-19 | 2004-05-24 | Schering Ag | Orthoanthranilamidderivater som antikoagulanter |
| AU1692399A (en) * | 1997-12-26 | 1999-07-19 | Mochida Pharmaceutical Co., Ltd. | Aromatic compounds having cyclic amino or salts thereof |
| EA200000768A1 (ru) * | 1998-01-27 | 2001-06-25 | Эвентис Фармасьютикалз Продактс Инк. | ЗАМЕЩЕННЫЕ ОКСОАЗАГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ ФАКТОРА Ха |
| CA2317017A1 (en) | 1998-02-05 | 1999-08-12 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
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| DE19835950A1 (de) * | 1998-08-08 | 2000-02-10 | Merck Patent Gmbh | Piperazinonderivate |
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| US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
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-
1995
- 1995-09-24 IL IL11542095A patent/IL115420A0/xx unknown
- 1995-09-25 AT AT95932128T patent/ATE168685T1/de not_active IP Right Cessation
- 1995-09-25 JP JP8511499A patent/JPH10506122A/ja not_active Withdrawn
- 1995-09-25 EP EP95932128A patent/EP0783500B1/de not_active Expired - Lifetime
- 1995-09-25 CZ CZ97893A patent/CZ285370B6/cs not_active IP Right Cessation
- 1995-09-25 SK SK385-97A patent/SK38597A3/sk unknown
- 1995-09-25 AU AU35307/95A patent/AU696491B2/en not_active Ceased
- 1995-09-25 CA CA002197471A patent/CA2197471A1/en not_active Abandoned
- 1995-09-25 WO PCT/GB1995/002285 patent/WO1996010022A1/en not_active Ceased
- 1995-09-25 ES ES95932128T patent/ES2119472T3/es not_active Expired - Lifetime
- 1995-09-25 PL PL95319430A patent/PL319430A1/xx unknown
- 1995-09-25 US US08/817,031 patent/US5965559A/en not_active Expired - Fee Related
- 1995-09-25 BR BR9509045A patent/BR9509045A/pt not_active Application Discontinuation
- 1995-09-25 DE DE69503647T patent/DE69503647T2/de not_active Expired - Fee Related
- 1995-09-25 NZ NZ292983A patent/NZ292983A/xx unknown
- 1995-09-25 HU HU9702052A patent/HUT77769A/hu unknown
- 1995-09-25 DK DK95932128T patent/DK0783500T3/da active
-
1997
- 1997-03-25 NO NO971415A patent/NO971415L/no unknown
-
1999
- 1999-08-09 US US09/369,857 patent/US6225309B1/en not_active Expired - Fee Related
-
2001
- 2001-03-08 US US09/800,745 patent/US6730672B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2119472T3 (es) | 1998-10-01 |
| NO971415L (no) | 1997-05-22 |
| EP0783500B1 (de) | 1998-07-22 |
| DE69503647T2 (de) | 1999-01-14 |
| HUT77769A (hu) | 1998-08-28 |
| CZ89397A3 (en) | 1997-07-16 |
| DK0783500T3 (da) | 1999-04-26 |
| US5965559A (en) | 1999-10-12 |
| BR9509045A (pt) | 1997-09-30 |
| US20020119968A1 (en) | 2002-08-29 |
| MX9701841A (es) | 1998-10-31 |
| NO971415D0 (no) | 1997-03-25 |
| CZ285370B6 (cs) | 1999-07-14 |
| DE69503647D1 (de) | 1998-08-27 |
| US6225309B1 (en) | 2001-05-01 |
| AU3530795A (en) | 1996-04-19 |
| AU696491B2 (en) | 1998-09-10 |
| PL319430A1 (en) | 1997-08-04 |
| IL115420A0 (en) | 1995-12-31 |
| EP0783500A1 (de) | 1997-07-16 |
| SK38597A3 (en) | 1997-09-10 |
| US6730672B2 (en) | 2004-05-04 |
| JPH10506122A (ja) | 1998-06-16 |
| CA2197471A1 (en) | 1996-04-04 |
| WO1996010022A1 (en) | 1996-04-04 |
| NZ292983A (en) | 1998-12-23 |
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| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |