ES2119472T3 - Derivados aminoheterociclicos como agentes antitromboticos o anticoagulantes. - Google Patents
Derivados aminoheterociclicos como agentes antitromboticos o anticoagulantes.Info
- Publication number
- ES2119472T3 ES2119472T3 ES95932128T ES95932128T ES2119472T3 ES 2119472 T3 ES2119472 T3 ES 2119472T3 ES 95932128 T ES95932128 T ES 95932128T ES 95932128 T ES95932128 T ES 95932128T ES 2119472 T3 ES2119472 T3 ES 2119472T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- aminoheterociclic
- thrombotic
- derivatives
- anticoagulant agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Cephalosporin Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE CADA UNO DE G{SUP,1}, G{SUP,2} Y G{SUP,3}, ES CH O N; M ES 1 O 2; R{SUP,1} INCLUYE HIDROGENO, HALOGENO Y ALQUILO (1-4C); M{SUP,1} ES UN GRUPO DE FORMULA: NR{SUP,2}-L{SUP,1}-T{SUP,1}R{SUP,3}, EN DONDE R{SUP,2} Y R{SUP,3} UNIDOS, FORMAN UN GRUPO ALQUILENO(14C), L{SUP,1} INCLUYE ALQUILENO(1-4C), Y T{SUP,1} ES CH O N; A PUEDE SER UN ENLACE DIRECTO; M{SUP,2} ES UN GRUPO DE FORMULA: (T{SUP,2}R{SUP,4}){SUB,R}-L{SUP,2}-T{SUP,3}R{SUP,5} EN DONDE R ES 0 O 1, CADA UNO DE T{SUP,2} Y T{SUP,3} ES CH O N, CADA UNO DE R{SUP,4} Y R{SUP,5} ES HIDROGENO, O ALQUILO(1-4C), O R{SUP,4} Y R{SUP,5} FORMAN UNIDOS UN GRUPO ALQUILENO(1-4C), Y L{SUP,2} INCLUYE ALQUILENO(1-4C); M{SUP,3} PUEDE SER UN ENLACE DIRECTO CON X; X COMPRENDE SULFONILO; Y Q COMPRENDE NAFTILO Y UNA FRACCION HETEROCICLICA; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. SE DESCRIBEN ASIMISMO PROCEDIMIENTOS DE PREPARACION DE LOS MISMOS, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, Y SU UTILIZACION COMO AGENTES ANTITROMBOTICOS O ANTICOAGULANTES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9419341A GB9419341D0 (en) | 1994-09-26 | 1994-09-26 | Aminoheterocyclic derivatives |
GBGB9425789.6A GB9425789D0 (en) | 1994-12-21 | 1994-12-21 | Aminoheterocyclic derivatives |
GBGB9511051.6A GB9511051D0 (en) | 1995-06-01 | 1995-06-01 | Aminoheterocyclic derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2119472T3 true ES2119472T3 (es) | 1998-10-01 |
Family
ID=27267394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95932128T Expired - Lifetime ES2119472T3 (es) | 1994-09-26 | 1995-09-25 | Derivados aminoheterociclicos como agentes antitromboticos o anticoagulantes. |
Country Status (18)
Country | Link |
---|---|
US (3) | US5965559A (es) |
EP (1) | EP0783500B1 (es) |
JP (1) | JPH10506122A (es) |
AT (1) | ATE168685T1 (es) |
AU (1) | AU696491B2 (es) |
BR (1) | BR9509045A (es) |
CA (1) | CA2197471A1 (es) |
CZ (1) | CZ285370B6 (es) |
DE (1) | DE69503647T2 (es) |
DK (1) | DK0783500T3 (es) |
ES (1) | ES2119472T3 (es) |
HU (1) | HUT77769A (es) |
IL (1) | IL115420A0 (es) |
NO (1) | NO971415L (es) |
NZ (1) | NZ292983A (es) |
PL (1) | PL319430A1 (es) |
SK (1) | SK38597A3 (es) |
WO (1) | WO1996010022A1 (es) |
Families Citing this family (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
JPH10511374A (ja) * | 1994-12-23 | 1998-11-04 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピペラジン誘導体、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法 |
AU707323B2 (en) | 1995-03-10 | 1999-07-08 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
GB9516709D0 (en) * | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
JP2000504336A (ja) * | 1996-02-02 | 2000-04-11 | ゼネカ・リミテッド | 薬学製剤として有用なヘテロ環式化合物 |
GB9602294D0 (en) * | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
US5994375A (en) * | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
BR9711135A (pt) * | 1996-08-14 | 1999-08-17 | Zeneca Ltd | Composto composi-Æo farmac-utica utiliza-Æo de um composto e processos para prepara-Æo de um composto e para inibi-Æo de Äxido-equaleno ciclase num animal de sangue quente requerendo um tal tratamento |
US5753635A (en) * | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
US5693641A (en) * | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
US6008234A (en) * | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
JP3565864B2 (ja) | 1996-09-12 | 2004-09-15 | シエーリング アクチエンゲゼルシヤフト | 環式アミノ酸または環式ヒドロキシ酸誘導体により置換されたベンズアミジン誘導体および抗擬固薬としてのこれらの使用 |
US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
AU5999698A (en) | 1997-02-13 | 1998-09-08 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
EP0966462B1 (en) * | 1997-02-13 | 2003-06-11 | AstraZeneca AB | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
EP0986551B1 (en) | 1997-05-30 | 2006-08-02 | Takeda Pharmaceutical Company Limited | Sulfonamide derivatives, their production and use |
GB9715894D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
GB9715892D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
GB9715895D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
DK1031563T3 (da) * | 1997-09-30 | 2006-05-08 | Daiichi Seiyaku Co | Sulfonylderivater |
US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
JP3811006B2 (ja) | 1997-12-19 | 2006-08-16 | シエーリング アクチエンゲゼルシャフト | 抗凝血物質類としてのオルト−アントラニルアミド誘導体類 |
EP1048652A4 (en) * | 1997-12-26 | 2001-05-09 | Mochida Pharm Co Ltd | AROMATIC COMPOUNDS WITH A CYCLIC AMINO GROUP OR THEIR SALTS |
SK11082000A3 (sk) * | 1998-01-27 | 2001-01-18 | Aventis Pharmaceuticals Products Inc. | Substituované oxoazaheterocyklické inhibítory faktora xa, farmaceutický prostriedok s ich obsahom a ich použitie |
EP1054005A4 (en) | 1998-02-05 | 2003-02-05 | Takeda Chemical Industries Ltd | SULFAMIDE DERIVATIVES, THEIR PRODUCTION PROCESS AND THEIR USE |
JP2002513790A (ja) * | 1998-05-02 | 2002-05-14 | アストラゼネカ アクチボラグ | Xa因子を阻害する複素環誘導体 |
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DE19835950A1 (de) * | 1998-08-08 | 2000-02-10 | Merck Patent Gmbh | Piperazinonderivate |
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DE19839499A1 (de) * | 1998-08-29 | 2000-03-02 | Merck Patent Gmbh | 2-Oxo-2H-chinolinderivate |
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US6127376A (en) * | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
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-
1995
- 1995-09-24 IL IL11542095A patent/IL115420A0/xx unknown
- 1995-09-25 DK DK95932128T patent/DK0783500T3/da active
- 1995-09-25 US US08/817,031 patent/US5965559A/en not_active Expired - Fee Related
- 1995-09-25 CZ CZ97893A patent/CZ285370B6/cs not_active IP Right Cessation
- 1995-09-25 ES ES95932128T patent/ES2119472T3/es not_active Expired - Lifetime
- 1995-09-25 PL PL95319430A patent/PL319430A1/xx unknown
- 1995-09-25 BR BR9509045A patent/BR9509045A/pt not_active Application Discontinuation
- 1995-09-25 NZ NZ292983A patent/NZ292983A/xx unknown
- 1995-09-25 AU AU35307/95A patent/AU696491B2/en not_active Ceased
- 1995-09-25 JP JP8511499A patent/JPH10506122A/ja not_active Withdrawn
- 1995-09-25 EP EP95932128A patent/EP0783500B1/en not_active Expired - Lifetime
- 1995-09-25 WO PCT/GB1995/002285 patent/WO1996010022A1/en not_active Application Discontinuation
- 1995-09-25 CA CA002197471A patent/CA2197471A1/en not_active Abandoned
- 1995-09-25 AT AT95932128T patent/ATE168685T1/de not_active IP Right Cessation
- 1995-09-25 HU HU9702052A patent/HUT77769A/hu unknown
- 1995-09-25 SK SK385-97A patent/SK38597A3/sk unknown
- 1995-09-25 DE DE69503647T patent/DE69503647T2/de not_active Expired - Fee Related
-
1997
- 1997-03-25 NO NO971415A patent/NO971415L/no unknown
-
1999
- 1999-08-09 US US09/369,857 patent/US6225309B1/en not_active Expired - Fee Related
-
2001
- 2001-03-08 US US09/800,745 patent/US6730672B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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CA2197471A1 (en) | 1996-04-04 |
BR9509045A (pt) | 1997-09-30 |
PL319430A1 (en) | 1997-08-04 |
AU3530795A (en) | 1996-04-19 |
CZ89397A3 (en) | 1997-07-16 |
US20020119968A1 (en) | 2002-08-29 |
US5965559A (en) | 1999-10-12 |
ATE168685T1 (de) | 1998-08-15 |
JPH10506122A (ja) | 1998-06-16 |
NO971415L (no) | 1997-05-22 |
NZ292983A (en) | 1998-12-23 |
US6730672B2 (en) | 2004-05-04 |
WO1996010022A1 (en) | 1996-04-04 |
CZ285370B6 (cs) | 1999-07-14 |
AU696491B2 (en) | 1998-09-10 |
DE69503647T2 (de) | 1999-01-14 |
IL115420A0 (en) | 1995-12-31 |
SK38597A3 (en) | 1997-09-10 |
EP0783500B1 (en) | 1998-07-22 |
US6225309B1 (en) | 2001-05-01 |
MX9701841A (es) | 1998-10-31 |
HUT77769A (hu) | 1998-08-28 |
DE69503647D1 (de) | 1998-08-27 |
DK0783500T3 (da) | 1999-04-26 |
EP0783500A1 (en) | 1997-07-16 |
NO971415D0 (no) | 1997-03-25 |
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