ES2119472T3 - Derivados aminoheterociclicos como agentes antitromboticos o anticoagulantes. - Google Patents

Derivados aminoheterociclicos como agentes antitromboticos o anticoagulantes.

Info

Publication number
ES2119472T3
ES2119472T3 ES95932128T ES95932128T ES2119472T3 ES 2119472 T3 ES2119472 T3 ES 2119472T3 ES 95932128 T ES95932128 T ES 95932128T ES 95932128 T ES95932128 T ES 95932128T ES 2119472 T3 ES2119472 T3 ES 2119472T3
Authority
ES
Spain
Prior art keywords
group
aminoheterociclic
thrombotic
derivatives
anticoagulant agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95932128T
Other languages
English (en)
Inventor
Alan Wellington Faull
Colette Marie Mayo
John Preston
Andrew Stocker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9419341A external-priority patent/GB9419341D0/en
Priority claimed from GBGB9425789.6A external-priority patent/GB9425789D0/en
Priority claimed from GBGB9511051.6A external-priority patent/GB9511051D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ES2119472T3 publication Critical patent/ES2119472T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE CADA UNO DE G{SUP,1}, G{SUP,2} Y G{SUP,3}, ES CH O N; M ES 1 O 2; R{SUP,1} INCLUYE HIDROGENO, HALOGENO Y ALQUILO (1-4C); M{SUP,1} ES UN GRUPO DE FORMULA: NR{SUP,2}-L{SUP,1}-T{SUP,1}R{SUP,3}, EN DONDE R{SUP,2} Y R{SUP,3} UNIDOS, FORMAN UN GRUPO ALQUILENO(14C), L{SUP,1} INCLUYE ALQUILENO(1-4C), Y T{SUP,1} ES CH O N; A PUEDE SER UN ENLACE DIRECTO; M{SUP,2} ES UN GRUPO DE FORMULA: (T{SUP,2}R{SUP,4}){SUB,R}-L{SUP,2}-T{SUP,3}R{SUP,5} EN DONDE R ES 0 O 1, CADA UNO DE T{SUP,2} Y T{SUP,3} ES CH O N, CADA UNO DE R{SUP,4} Y R{SUP,5} ES HIDROGENO, O ALQUILO(1-4C), O R{SUP,4} Y R{SUP,5} FORMAN UNIDOS UN GRUPO ALQUILENO(1-4C), Y L{SUP,2} INCLUYE ALQUILENO(1-4C); M{SUP,3} PUEDE SER UN ENLACE DIRECTO CON X; X COMPRENDE SULFONILO; Y Q COMPRENDE NAFTILO Y UNA FRACCION HETEROCICLICA; O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. SE DESCRIBEN ASIMISMO PROCEDIMIENTOS DE PREPARACION DE LOS MISMOS, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, Y SU UTILIZACION COMO AGENTES ANTITROMBOTICOS O ANTICOAGULANTES.
ES95932128T 1994-09-26 1995-09-25 Derivados aminoheterociclicos como agentes antitromboticos o anticoagulantes. Expired - Lifetime ES2119472T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9419341A GB9419341D0 (en) 1994-09-26 1994-09-26 Aminoheterocyclic derivatives
GBGB9425789.6A GB9425789D0 (en) 1994-12-21 1994-12-21 Aminoheterocyclic derivatives
GBGB9511051.6A GB9511051D0 (en) 1995-06-01 1995-06-01 Aminoheterocyclic derivatives

Publications (1)

Publication Number Publication Date
ES2119472T3 true ES2119472T3 (es) 1998-10-01

Family

ID=27267394

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95932128T Expired - Lifetime ES2119472T3 (es) 1994-09-26 1995-09-25 Derivados aminoheterociclicos como agentes antitromboticos o anticoagulantes.

Country Status (18)

Country Link
US (3) US5965559A (es)
EP (1) EP0783500B1 (es)
JP (1) JPH10506122A (es)
AT (1) ATE168685T1 (es)
AU (1) AU696491B2 (es)
BR (1) BR9509045A (es)
CA (1) CA2197471A1 (es)
CZ (1) CZ285370B6 (es)
DE (1) DE69503647T2 (es)
DK (1) DK0783500T3 (es)
ES (1) ES2119472T3 (es)
HU (1) HUT77769A (es)
IL (1) IL115420A0 (es)
NO (1) NO971415L (es)
NZ (1) NZ292983A (es)
PL (1) PL319430A1 (es)
SK (1) SK38597A3 (es)
WO (1) WO1996010022A1 (es)

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DE69503647D1 (de) 1998-08-27
BR9509045A (pt) 1997-09-30
SK38597A3 (en) 1997-09-10
NO971415L (no) 1997-05-22
NZ292983A (en) 1998-12-23
DK0783500T3 (da) 1999-04-26
MX9701841A (es) 1998-10-31
AU3530795A (en) 1996-04-19
HUT77769A (hu) 1998-08-28
EP0783500A1 (en) 1997-07-16
EP0783500B1 (en) 1998-07-22
US6730672B2 (en) 2004-05-04
JPH10506122A (ja) 1998-06-16
US20020119968A1 (en) 2002-08-29
PL319430A1 (en) 1997-08-04
CZ285370B6 (cs) 1999-07-14
AU696491B2 (en) 1998-09-10
US6225309B1 (en) 2001-05-01
CZ89397A3 (en) 1997-07-16
NO971415D0 (no) 1997-03-25
US5965559A (en) 1999-10-12
WO1996010022A1 (en) 1996-04-04
ATE168685T1 (de) 1998-08-15
IL115420A0 (en) 1995-12-31
CA2197471A1 (en) 1996-04-04

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