ES8700672A1 - Un procedimiento para la preparacion de derivados de amino alquilentio-alquilentiofosfonatos. - Google Patents

Un procedimiento para la preparacion de derivados de amino alquilentio-alquilentiofosfonatos.

Info

Publication number
ES8700672A1
ES8700672A1 ES537293A ES537293A ES8700672A1 ES 8700672 A1 ES8700672 A1 ES 8700672A1 ES 537293 A ES537293 A ES 537293A ES 537293 A ES537293 A ES 537293A ES 8700672 A1 ES8700672 A1 ES 8700672A1
Authority
ES
Spain
Prior art keywords
phenobarbital
carbamazepine
enzyme inhibitors
chem
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES537293A
Other languages
English (en)
Other versions
ES537293A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/548,742 external-priority patent/US4559173A/en
Priority claimed from US06/548,743 external-priority patent/US4543412A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES8700672A1 publication Critical patent/ES8700672A1/es
Publication of ES537293A0 publication Critical patent/ES537293A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

METODO DE PREPARACION DE DERIVADOS DE AMINOALQUILENTIOALQUILENTIOFOSFONATOS. CONJUGADOS DE FENOBARBITAL Y CARBAMAZEPINA DE FORMULA (I) QUE PUEDEN SER UTILIZADOS COMO INHIBIDORES DE ENZIMAS. PARA LA OBTENCION SE HACE REACCIONAR UN ANALOGO DE 5-HIDROXI-FENOBARBITAL CON FOSGENO PARA DAR EL CORRESPONDIENTE DERIVADO DE CLORURO DE ACETILO. UN FOSFONATO PROTEGIDO CON N-BUTOXICARBONILO SE TRANSFORMA EN LA CORRESPONDIENTE SAL TRIFLUOROACETICA. POR REACCION DEL CLORURO DE ACETILO Y LA SAL SE PREPARA LA AMIDA DEL FENOBARBITAL. EL METODO DESCRITO CONSTITUYE UNA TECNICA DE INMUNOENSAYO CONVENIENTE PARA MEDIR LA CANTIDAD PRESENTE DE DIVERSAS DROGAS, Y HORMONAS EN FLUIDOS BIOLOGICOS.
ES537293A 1983-11-04 1984-10-31 Un procedimiento para la preparacion de derivados de amino alquilentio-alquilentiofosfonatos. Expired ES8700672A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/548,742 US4559173A (en) 1983-11-04 1983-11-04 N-substituted dibenz[b,f]azepine salts
US06/548,743 US4543412A (en) 1983-11-04 1983-11-04 Phenobarbital enzyme inhibitors

Publications (2)

Publication Number Publication Date
ES8700672A1 true ES8700672A1 (es) 1986-10-16
ES537293A0 ES537293A0 (es) 1986-10-16

Family

ID=27068936

Family Applications (1)

Application Number Title Priority Date Filing Date
ES537293A Expired ES8700672A1 (es) 1983-11-04 1984-10-31 Un procedimiento para la preparacion de derivados de amino alquilentio-alquilentiofosfonatos.

Country Status (10)

Country Link
EP (1) EP0141393B1 (es)
KR (1) KR900001620B1 (es)
AU (1) AU566518B2 (es)
CA (1) CA1224783A (es)
DE (1) DE3473456D1 (es)
DK (1) DK522884A (es)
ES (1) ES8700672A1 (es)
GR (1) GR80827B (es)
IE (1) IE58318B1 (es)
IL (1) IL73293A (es)

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US5414085A (en) * 1992-04-06 1995-05-09 Biosite Diagnostics, Inc. Barbiturate derivatives and protein and polypeptide barbiturate derivative conjugates and labels
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US9266823B2 (en) 2012-05-08 2016-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of parkinson's disease
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WO2013168025A1 (en) 2012-05-08 2013-11-14 Mahesh Kandula Compositions and methods for treatment of blood clotting disorders
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
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US9339484B2 (en) 2012-05-10 2016-05-17 Cellix Bio Private Limited Compositions and methods for the treatment of restless leg syndrome and fibromyalgia
WO2013168033A1 (en) 2012-05-10 2013-11-14 Mahesh Kandula Compositions and methods for treatment of neurologic diseases
JP2015518855A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 粘膜炎の治療のための組成物および方法
JP2015518854A (ja) 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
WO2013175347A2 (en) 2012-05-23 2013-11-28 Mahesh Kandula Compositions and methods for the treatment of respiratory disorders
JP6202287B2 (ja) 2012-05-23 2017-09-27 セリックスビオ プライヴェート リミテッド 炎症性腸疾患の治療のための組成物及び方法
US9492409B2 (en) 2012-05-23 2016-11-15 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US9434729B2 (en) 2012-05-23 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (en) 2012-08-03 2014-02-06 Mahesh Kandula Compositions and methods for the treatment migraine and neurologic diseases
US9624168B2 (en) 2012-09-06 2017-04-18 Cellix Bio Private Limited Compositions and methods for the treatment inflammation and lipid disorders
SG11201407325YA (en) 2012-09-08 2014-12-30 Cellix Bio Private Ltd Compositions and methods for treatment of inflammation and lipid disorders
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
EP3004049B1 (en) 2013-06-04 2018-09-05 Cellixbio Private Limited Compositions and methods for the treatment of diabetes and pre-diabetes
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
EP3240779B1 (en) 2014-09-26 2020-10-28 Cellixbio Private Limited Compositions and methods for the treatment of epilepsy and neurological disorders
EP3201168B1 (en) 2014-09-29 2020-03-18 Cellix Bio Private Limited Compounds and compositions for the treatment of multiple sclerosis
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US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273866A (en) * 1979-02-05 1981-06-16 Abbott Laboratories Ligand analog-irreversible enzyme inhibitor conjugates and methods for use

Also Published As

Publication number Publication date
CA1224783A (en) 1987-07-28
IL73293A (en) 1988-02-29
AU3471284A (en) 1985-05-09
EP0141393B1 (en) 1988-08-17
AU566518B2 (en) 1987-10-22
IL73293A0 (en) 1985-01-31
KR900001620B1 (ko) 1990-03-17
DK522884D0 (da) 1984-11-02
GR80827B (en) 1985-03-05
EP0141393A2 (en) 1985-05-15
IE842828L (en) 1985-05-04
DK522884A (da) 1985-05-05
IE58318B1 (en) 1993-09-08
ES537293A0 (es) 1986-10-16
EP0141393A3 (en) 1985-07-03
KR850004111A (ko) 1985-07-01
DE3473456D1 (en) 1988-09-22

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401