ES8400752A1 - "procedimiento para la preparacion de nuevos derivados de ciclofosfamida". - Google Patents
"procedimiento para la preparacion de nuevos derivados de ciclofosfamida".Info
- Publication number
- ES8400752A1 ES8400752A1 ES514852A ES514852A ES8400752A1 ES 8400752 A1 ES8400752 A1 ES 8400752A1 ES 514852 A ES514852 A ES 514852A ES 514852 A ES514852 A ES 514852A ES 8400752 A1 ES8400752 A1 ES 8400752A1
- Authority
- ES
- Spain
- Prior art keywords
- cyclophosphamide
- derivatives
- preparation
- novel
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical class ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 title abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE CICLOFOSFAMIDA. SE HACE REACCIONAR EL COMPUESTO (II) EN UN DISOLVENTE ORGANICO Y EN PRESENCIA DE UNA BASE, CON DICLORURO DE N,N-BIS(2-CLOROETIL)-FOSFAM IDA O CON OXITRICLORURO DE FOSFORO Y CLORHIDRATO DE BIS(2-CLOROETIL)-AMINA. SI SE DESEA EL COMPUESTO OBTENIDO (I) SE TRANSFORMA EN OTRO EN EL CUAL R SEA ALGUNO DE LOS RADICALES HIDROGENO, HIDROCARBONADO, O HETEROCICLICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813132221 DE3132221A1 (de) | 1981-08-14 | 1981-08-14 | Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8400752A1 true ES8400752A1 (es) | 1983-11-01 |
ES514852A0 ES514852A0 (es) | 1983-11-01 |
Family
ID=6139355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514852A Granted ES514852A0 (es) | 1981-08-14 | 1982-08-09 | "procedimiento para la preparacion de nuevos derivados de ciclofosfamida". |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0072531A1 (es) |
JP (1) | JPS5841892A (es) |
AU (1) | AU8717082A (es) |
DE (1) | DE3132221A1 (es) |
DK (1) | DK364782A (es) |
ES (1) | ES514852A0 (es) |
PT (1) | PT75416B (es) |
ZA (1) | ZA825876B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3225227A1 (de) * | 1982-07-06 | 1984-01-12 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids |
ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
FR2684102B1 (fr) * | 1991-11-21 | 1994-03-11 | Etat Francais Delegue Armement | Procede de preparation de polyazidoalcools ainsi que de polyaminoalcools et polyazidothiols derives de ceux-ci. |
EP1165570B9 (en) * | 1999-03-05 | 2007-02-21 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing prodrugs |
US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
EP1634886A3 (en) * | 1999-03-05 | 2006-03-29 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing prodrug |
US6506739B1 (en) | 2001-05-01 | 2003-01-14 | Telik, Inc. | Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents |
FR2968662B1 (fr) * | 2010-12-10 | 2013-11-22 | Roussy Inst Gustave | Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation |
US10449210B2 (en) | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
US11970482B2 (en) | 2018-01-09 | 2024-04-30 | Ligand Pharmaceuticals Inc. | Acetal compounds and therapeutic uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR75178E (es) * | 1956-12-20 | 1961-09-08 | ||
JPS5230519B2 (es) * | 1972-04-05 | 1977-08-09 | ||
PL100390B1 (pl) * | 1975-10-06 | 1978-09-30 | Sposob wytwarzania 2-tlenku-2-/bis/2-chloroetylo/-amino/-1-/okso-3-aza-2-fosfacykloheksanu/cyklofosfamidu/o czynnosci optycznej |
-
1981
- 1981-08-14 DE DE19813132221 patent/DE3132221A1/de not_active Withdrawn
-
1982
- 1982-08-09 ES ES514852A patent/ES514852A0/es active Granted
- 1982-08-11 EP EP82107270A patent/EP0072531A1/de not_active Withdrawn
- 1982-08-12 PT PT75416A patent/PT75416B/pt unknown
- 1982-08-13 ZA ZA825876A patent/ZA825876B/xx unknown
- 1982-08-13 AU AU87170/82A patent/AU8717082A/en not_active Abandoned
- 1982-08-13 JP JP57139982A patent/JPS5841892A/ja active Pending
- 1982-08-13 DK DK364782A patent/DK364782A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PT75416A (de) | 1982-09-01 |
DE3132221A1 (de) | 1983-05-19 |
JPS5841892A (ja) | 1983-03-11 |
PT75416B (de) | 1985-05-31 |
EP0072531A1 (de) | 1983-02-23 |
DK364782A (da) | 1983-02-15 |
AU8717082A (en) | 1983-02-17 |
ZA825876B (en) | 1983-06-29 |
ES514852A0 (es) | 1983-11-01 |
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