ES8400752A1 - "procedimiento para la preparacion de nuevos derivados de ciclofosfamida". - Google Patents

"procedimiento para la preparacion de nuevos derivados de ciclofosfamida".

Info

Publication number
ES8400752A1
ES8400752A1 ES514852A ES514852A ES8400752A1 ES 8400752 A1 ES8400752 A1 ES 8400752A1 ES 514852 A ES514852 A ES 514852A ES 514852 A ES514852 A ES 514852A ES 8400752 A1 ES8400752 A1 ES 8400752A1
Authority
ES
Spain
Prior art keywords
cyclophosphamide
derivatives
preparation
novel
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514852A
Other languages
English (en)
Other versions
ES514852A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Behringwerke AG
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG, Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Behringwerke AG
Publication of ES514852A0 publication Critical patent/ES514852A0/es
Publication of ES8400752A1 publication Critical patent/ES8400752A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE CICLOFOSFAMIDA. SE HACE REACCIONAR EL COMPUESTO (II) EN UN DISOLVENTE ORGANICO Y EN PRESENCIA DE UNA BASE, CON DICLORURO DE N,N-BIS(2-CLOROETIL)-FOSFAM IDA O CON OXITRICLORURO DE FOSFORO Y CLORHIDRATO DE BIS(2-CLOROETIL)-AMINA. SI SE DESEA EL COMPUESTO OBTENIDO (I) SE TRANSFORMA EN OTRO EN EL CUAL R SEA ALGUNO DE LOS RADICALES HIDROGENO, HIDROCARBONADO, O HETEROCICLICO.
ES514852A 1981-08-14 1982-08-09 "procedimiento para la preparacion de nuevos derivados de ciclofosfamida". Expired ES8400752A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813132221 DE3132221A1 (de) 1981-08-14 1981-08-14 Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
ES514852A0 ES514852A0 (es) 1983-11-01
ES8400752A1 true ES8400752A1 (es) 1983-11-01

Family

ID=6139355

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514852A Expired ES8400752A1 (es) 1981-08-14 1982-08-09 "procedimiento para la preparacion de nuevos derivados de ciclofosfamida".

Country Status (8)

Country Link
EP (1) EP0072531A1 (es)
JP (1) JPS5841892A (es)
AU (1) AU8717082A (es)
DE (1) DE3132221A1 (es)
DK (1) DK364782A (es)
ES (1) ES8400752A1 (es)
PT (1) PT75416B (es)
ZA (1) ZA825876B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225227A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
FR2684102B1 (fr) * 1991-11-21 1994-03-11 Etat Francais Delegue Armement Procede de preparation de polyazidoalcools ainsi que de polyaminoalcools et polyazidothiols derives de ceux-ci.
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
EP1634886A3 (en) * 1999-03-05 2006-03-29 Metabasis Therapeutics, Inc. Novel phosphorus-containing prodrug
WO2000052015A2 (en) * 1999-03-05 2000-09-08 Metabasis Therapeutics, Inc. Novel phosphorus-containing prodrugs
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
FR2968662B1 (fr) * 2010-12-10 2013-11-22 Roussy Inst Gustave Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation
JP2017512183A (ja) 2014-02-13 2017-05-18 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
US11970482B2 (en) 2018-01-09 2024-04-30 Ligand Pharmaceuticals Inc. Acetal compounds and therapeutic uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR75178E (es) * 1956-12-20 1961-09-08
JPS5230519B2 (es) * 1972-04-05 1977-08-09
PL100390B1 (pl) * 1975-10-06 1978-09-30 Sposob wytwarzania 2-tlenku-2-/bis/2-chloroetylo/-amino/-1-/okso-3-aza-2-fosfacykloheksanu/cyklofosfamidu/o czynnosci optycznej

Also Published As

Publication number Publication date
JPS5841892A (ja) 1983-03-11
PT75416A (de) 1982-09-01
DE3132221A1 (de) 1983-05-19
PT75416B (de) 1985-05-31
ES514852A0 (es) 1983-11-01
AU8717082A (en) 1983-02-17
ZA825876B (en) 1983-06-29
DK364782A (da) 1983-02-15
EP0072531A1 (de) 1983-02-23

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