ES8304969A1 - Procedimiento para la obtencion de 2-aril-3,4-diazabiciclo 4.n.0-alq-2-en-5-onas. - Google Patents

Procedimiento para la obtencion de 2-aril-3,4-diazabiciclo 4.n.0-alq-2-en-5-onas.

Info

Publication number
ES8304969A1
ES8304969A1 ES513391A ES513391A ES8304969A1 ES 8304969 A1 ES8304969 A1 ES 8304969A1 ES 513391 A ES513391 A ES 513391A ES 513391 A ES513391 A ES 513391A ES 8304969 A1 ES8304969 A1 ES 8304969A1
Authority
ES
Spain
Prior art keywords
aryl
ones
compounds
alken
diaza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513391A
Other languages
English (en)
Other versions
ES513391A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES513391A0 publication Critical patent/ES513391A0/es
Publication of ES8304969A1 publication Critical patent/ES8304969A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-ARIL-3,4-DIAZABICICLO 4.N.0 -ALQ-2-EN-5-ONAS, DE FORMULA (I), EN LAS QUE M Y N VALEN 1-3; Y R, R , R Y R SON HIDROGENO O ALQUILO C <- . CONSISTE EN LA REACCION DE UN ACIDO CICLOALCANOCARBOXILICO DE FORMULA (II) CON UNA HIDRACINA DE FORMULA NH NHR, EN LAS QUE R, R , R , R , M Y N TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION DE CICLIZACION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 40 C Y 150 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA LA PROFILAXIS Y TERAPIA DE AFECCIONES TROMBOEMBOLICAS Y EN CASO DE HIPERTENSION.
ES513391A 1981-06-24 1982-06-23 Procedimiento para la obtencion de 2-aril-3,4-diazabiciclo 4.n.0-alq-2-en-5-onas. Expired ES8304969A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813124699 DE3124699A1 (de) 1981-06-24 1981-06-24 Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES513391A0 ES513391A0 (es) 1983-03-16
ES8304969A1 true ES8304969A1 (es) 1983-03-16

Family

ID=6135223

Family Applications (1)

Application Number Title Priority Date Filing Date
ES513391A Expired ES8304969A1 (es) 1981-06-24 1982-06-23 Procedimiento para la obtencion de 2-aril-3,4-diazabiciclo 4.n.0-alq-2-en-5-onas.

Country Status (16)

Country Link
US (1) US4474785A (es)
EP (1) EP0068310B1 (es)
JP (1) JPS58975A (es)
AT (1) ATE8891T1 (es)
AU (1) AU548396B2 (es)
CA (1) CA1171412A (es)
CS (1) CS227692B2 (es)
DE (2) DE3124699A1 (es)
DK (1) DK281482A (es)
ES (1) ES8304969A1 (es)
FI (1) FI73425C (es)
GR (1) GR76010B (es)
HU (1) HU188179B (es)
IL (1) IL66009A (es)
NO (1) NO822102L (es)
ZA (1) ZA824438B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591591A (en) * 1984-03-08 1986-05-27 Eli Lilly And Company Pyridazinone derivatives as inotropic agents
US4647564A (en) * 1984-05-14 1987-03-03 Eli Lilly And Company Inotropic agents
CA1248099A (en) * 1984-05-14 1989-01-03 David W. Robertson Indoline and 2-indolinone derivatives
JPS6135240A (ja) * 1984-07-27 1986-02-19 新東工業株式会社 フルモ−ルド用発泡成形体
US4617302A (en) * 1984-10-15 1986-10-14 Eli Lilly And Company Inotropic agents
JPH0662608B2 (ja) * 1985-08-26 1994-08-17 大塚製薬株式会社 カルボスチリル誘導体
DE3535170A1 (de) * 1985-10-02 1987-04-16 Basf Ag Verwendung von 2-aryl-3,4-diaza-bicyclo(4.n.0)alken-(2)-onen-(5) zur behandlung der herzinsuffizienz
DE3535949A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
DE3535947A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
JPH02153730A (ja) * 1988-10-24 1990-06-13 Kanayama Kasei Kk 断熱を要する機器の表面材
US5607863A (en) 1991-05-29 1997-03-04 Smithkline Diagnostics, Inc. Barrier-controlled assay device
US5869345A (en) 1991-05-29 1999-02-09 Smithkline Diagnostics, Inc. Opposable-element assay device employing conductive barrier
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
JP3442815B2 (ja) * 1992-05-13 2003-09-02 第一製薬株式会社 ジアザビシクロアルケン誘導体
SE9901825D0 (sv) 1999-05-20 1999-05-20 Amersham Pharm Biotech Ab Foamed material filled with inner material
WO2013151707A1 (en) * 2012-04-05 2013-10-10 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2015047982A2 (en) 2013-09-26 2015-04-02 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
EP3049389B1 (en) * 2013-09-26 2019-08-07 CHDI Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
US3746712A (en) * 1971-06-08 1973-07-17 A Ross 6-(substituted-phenyl)-5-methyl-4,5-dihydro-3(2h)-pyridazinones
US3812256A (en) * 1971-06-08 1974-05-21 American Cyanamid Co Novel method for lowering blood pressure in mammals
US3824271A (en) * 1972-07-20 1974-07-16 American Cyanamid Co 3-alkyl-3-(benzoyl)propionitriles
US3888901A (en) * 1972-07-20 1975-06-10 American Cyanamid Co Process of preparing 3-alkyl-3-(benzoyl)propionitriles
DE2304977A1 (de) * 1973-02-01 1974-08-08 Basf Ag Neue dihydropyridazinone
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
DE2727481A1 (de) * 1977-06-18 1979-01-11 Basf Ag Dihydropyridazone und dihydropyridazone enthaltende therapeutische mittel
JPS54135785A (en) * 1978-04-12 1979-10-22 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivative and its preparation
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE2845220A1 (de) * 1978-10-17 1980-04-30 Yoshitomi Pharmaceutical Pyridazinon-derivate, ihre salze mit saeuren, verfahren zu ihrer herstellung und ihre verwendung bei der behandlung von thrombosen und hypertonie
DE2845456A1 (de) * 1978-10-19 1980-08-14 Merck Patent Gmbh 6-arylpyridazin-3-one und verfahren zu ihrer herstellung
DE2854191A1 (de) * 1978-12-15 1980-07-03 Basf Ag Dihydropyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel
DE2854475A1 (de) * 1978-12-16 1980-07-03 Basf Ag Neue 3,4-diaza-bicyclo eckige klammer auf 4.1.0 eckige klammer zu hepten-(2)- one-(5), verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel

Also Published As

Publication number Publication date
FI822203A0 (fi) 1982-06-18
FI73425B (fi) 1987-06-30
NO822102L (no) 1982-12-27
DK281482A (da) 1982-12-25
IL66009A (en) 1986-02-28
CA1171412A (en) 1984-07-24
GR76010B (es) 1984-08-03
ES513391A0 (es) 1983-03-16
EP0068310A1 (de) 1983-01-05
FI822203L (fi) 1982-12-25
DE3124699A1 (de) 1983-01-13
IL66009A0 (en) 1982-09-30
AU548396B2 (en) 1985-12-12
DE3260540D1 (en) 1984-09-13
FI73425C (fi) 1987-10-09
US4474785A (en) 1984-10-02
AU8515382A (en) 1983-01-13
EP0068310B1 (de) 1984-08-08
ZA824438B (en) 1983-05-25
JPS58975A (ja) 1983-01-06
HU188179B (en) 1986-03-28
CS227692B2 (en) 1984-05-14
ATE8891T1 (de) 1984-08-15

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