ES8303400A1 - "procedimiento para preparar derivados de bencilazol." - Google Patents
"procedimiento para preparar derivados de bencilazol."Info
- Publication number
- ES8303400A1 ES8303400A1 ES512151A ES512151A ES8303400A1 ES 8303400 A1 ES8303400 A1 ES 8303400A1 ES 512151 A ES512151 A ES 512151A ES 512151 A ES512151 A ES 512151A ES 8303400 A1 ES8303400 A1 ES 8303400A1
- Authority
- ES
- Spain
- Prior art keywords
- benzylazole
- derivatives
- epoxypropyloxybenzylazole
- chem
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENCILAZOL Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, B, X, Y, Z, R Y R PUEDEN SER VARIOS RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA R NHR , EN LAS QUE TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN PRESENCIA O AUSENCIA DE UN DISOLVENTE INERTE, A UNA TEMPERATURA ENTRE 25 C Y 100 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIARRITMICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56072986A JPS57188570A (en) | 1981-05-14 | 1981-05-14 | Benzylazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
ES512151A0 ES512151A0 (es) | 1983-02-01 |
ES8303400A1 true ES8303400A1 (es) | 1983-02-01 |
Family
ID=13505217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES512151A Expired ES8303400A1 (es) | 1981-05-14 | 1982-05-13 | "procedimiento para preparar derivados de bencilazol." |
Country Status (16)
Country | Link |
---|---|
US (1) | US4430331A (es) |
EP (1) | EP0066144B1 (es) |
JP (1) | JPS57188570A (es) |
KR (1) | KR860001580B1 (es) |
AU (1) | AU554243B2 (es) |
CA (1) | CA1193255A (es) |
DE (2) | DE3269141D1 (es) |
DK (1) | DK161317C (es) |
ES (1) | ES8303400A1 (es) |
GB (1) | GB2103600B (es) |
HU (1) | HU188059B (es) |
IE (1) | IE52989B1 (es) |
IL (1) | IL65735A (es) |
NZ (1) | NZ200471A (es) |
PH (1) | PH17989A (es) |
ZA (1) | ZA823207B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3343671A1 (de) * | 1983-12-02 | 1985-06-20 | Basf Ag, 6700 Ludwigshafen | Aminopropanolderivate von substituierten 2-hydroxy-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3870726A (en) | 1970-09-09 | 1975-03-11 | Bayer Ag | Derivatives of 3-azolylpropyne and processes for their preparation and use |
CH584695A5 (en) * | 1973-02-20 | 1977-02-15 | Ciba Geigy Ag | 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity |
SE7601713L (sv) * | 1975-03-03 | 1976-09-06 | Merck & Co Inc | Nya, substituerad imidazoler |
CA1111433A (en) * | 1977-10-19 | 1981-10-27 | Peter B. Thorogood | Imidazole derivatives and their salts |
US4210653A (en) * | 1978-06-27 | 1980-07-01 | Merck & Co., Inc. | Pyridyloxypropanolamines |
JPS5951943B2 (ja) * | 1978-08-21 | 1984-12-17 | キツセイ薬品工業株式会社 | 新規なイミダゾ−ル誘導体 |
GB2041363B (en) * | 1979-01-19 | 1982-10-06 | Pfizer Ltd | N-benzyl-imidazoles |
DK157860C (da) * | 1979-06-07 | 1990-07-30 | Shionogi & Co | Analogifremgangsmaade til fremstilling af benzylimidazolderivater samt farmaceutisk acceptable syreadditionssalte deraf |
IE810250L (en) * | 1980-02-11 | 1981-08-11 | Berlex Lab | N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines. |
CA1156661A (en) * | 1980-02-25 | 1983-11-08 | Hoffmann-La Roche Limited | Phenoxy-aminopropanol derivatives |
-
1981
- 1981-05-14 JP JP56072986A patent/JPS57188570A/ja active Granted
-
1982
- 1982-04-29 US US06/372,951 patent/US4430331A/en not_active Expired - Fee Related
- 1982-04-30 AU AU83180/82A patent/AU554243B2/en not_active Ceased
- 1982-04-30 NZ NZ200471A patent/NZ200471A/en unknown
- 1982-05-10 ZA ZA823207A patent/ZA823207B/xx unknown
- 1982-05-11 CA CA000403693A patent/CA1193255A/en not_active Expired
- 1982-05-11 IE IE1134/82A patent/IE52989B1/en not_active IP Right Cessation
- 1982-05-11 IL IL65735A patent/IL65735A/xx not_active IP Right Cessation
- 1982-05-13 DK DK216282A patent/DK161317C/da not_active IP Right Cessation
- 1982-05-13 GB GB08213956A patent/GB2103600B/en not_active Expired
- 1982-05-13 DE DE8282104196T patent/DE3269141D1/de not_active Expired
- 1982-05-13 DE DE198282104196T patent/DE66144T1/de active Pending
- 1982-05-13 ES ES512151A patent/ES8303400A1/es not_active Expired
- 1982-05-13 EP EP82104196A patent/EP0066144B1/en not_active Expired
- 1982-05-13 PH PH27294A patent/PH17989A/en unknown
- 1982-05-13 HU HU821509A patent/HU188059B/hu not_active IP Right Cessation
- 1982-05-14 KR KR8202102A patent/KR860001580B1/ko active
Also Published As
Publication number | Publication date |
---|---|
IL65735A (en) | 1986-04-29 |
EP0066144A2 (en) | 1982-12-08 |
NZ200471A (en) | 1985-08-30 |
GB2103600B (en) | 1985-01-09 |
ES512151A0 (es) | 1983-02-01 |
JPS6325583B2 (es) | 1988-05-26 |
CA1193255A (en) | 1985-09-10 |
PH17989A (en) | 1985-02-28 |
DK161317C (da) | 1991-12-30 |
ZA823207B (en) | 1983-03-30 |
KR830010079A (ko) | 1983-12-26 |
JPS57188570A (en) | 1982-11-19 |
IL65735A0 (en) | 1982-08-31 |
AU8318082A (en) | 1982-11-18 |
DE66144T1 (de) | 1983-05-26 |
DE3269141D1 (de) | 1986-03-27 |
GB2103600A (en) | 1983-02-23 |
EP0066144A3 (en) | 1983-11-30 |
AU554243B2 (en) | 1986-08-14 |
DK216282A (da) | 1982-11-15 |
HU188059B (en) | 1986-03-28 |
US4430331A (en) | 1984-02-07 |
KR860001580B1 (ko) | 1986-10-10 |
DK161317B (da) | 1991-06-24 |
IE821134L (en) | 1982-11-14 |
IE52989B1 (en) | 1988-04-27 |
EP0066144B1 (en) | 1986-02-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971001 |