ES479627A1 - Un procedimiento para la preparacion de 1,4-bis-piperonilpi-peracina y similares. - Google Patents
Un procedimiento para la preparacion de 1,4-bis-piperonilpi-peracina y similares.Info
- Publication number
- ES479627A1 ES479627A1 ES479627A ES479627A ES479627A1 ES 479627 A1 ES479627 A1 ES 479627A1 ES 479627 A ES479627 A ES 479627A ES 479627 A ES479627 A ES 479627A ES 479627 A1 ES479627 A1 ES 479627A1
- Authority
- ES
- Spain
- Prior art keywords
- piperonylpiperazine
- bis
- preparing
- similar compounds
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Un procedimiento para la preparación de 1,4-bis- piperonilpiperacina y similares, de la fórmula general **(Fórmula)** en donde Ar es un anillo bencénico, substituido o insubstituido, caracterizado porque comprende las etapas de hacer reaccionar a temperatura elevada, cantidades equimolares de piperacina y de un cloruro Ar-CH2-Cl (en donde Ar tiene el significado antes indicado) en presencia de agua, bajo agitación, y en presencia de una cantidad catalítica de un agente tensoactivo catiónico, y recuperar el compuesto (I) de la masa reacional.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT67951/78A IT1156989B (it) | 1978-04-27 | 1978-04-27 | Procedimento per la preparazione della i.4 bis piperonil piperazina e dei composti analoghi |
Publications (1)
Publication Number | Publication Date |
---|---|
ES479627A1 true ES479627A1 (es) | 1979-08-01 |
Family
ID=11306645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479627A Expired ES479627A1 (es) | 1978-04-27 | 1979-04-17 | Un procedimiento para la preparacion de 1,4-bis-piperonilpi-peracina y similares. |
Country Status (12)
Country | Link |
---|---|
US (1) | US4264770A (es) |
JP (1) | JPS54154777A (es) |
BE (1) | BE875886A (es) |
CH (1) | CH638192A5 (es) |
DE (1) | DE2916991C3 (es) |
ES (1) | ES479627A1 (es) |
FR (1) | FR2424263A1 (es) |
GB (1) | GB2020274B (es) |
GR (1) | GR68530B (es) |
IT (1) | IT1156989B (es) |
NL (1) | NL7903062A (es) |
PT (1) | PT69540A (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037077A1 (en) * | 1997-02-24 | 1998-08-27 | Zymogenetics, Inc. | Calcitonin mimetics |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3066655D1 (en) * | 1979-12-20 | 1984-03-22 | Hoechst Ag | Process for the production of n,n'-diaryl-alkylene diamines or n,n',n"-triaryl-dialkylene triamines |
DE3571605D1 (en) * | 1984-01-06 | 1989-08-24 | Dow Chemical Co | Process for decolorizing polyethylene polyamines with a chlorinated hydrocarbon |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870152A (en) * | 1959-01-20 | Unilcu | ||
US2415786A (en) * | 1944-01-06 | 1947-02-11 | Burroughs Wellcome Co | Unsymmetrically substituted piperazines |
US2695294A (en) * | 1952-12-19 | 1954-11-23 | Mcneilab Inc | N, n'-substituted diamine compounds and method of making the same |
US2887488A (en) * | 1957-09-23 | 1959-05-19 | Du Pont | Piperazine derivatives |
FR1312427A (fr) * | 1961-04-12 | 1962-12-21 | Science Union Et Compagnie Soc | Nouveaux dérivés de la pipérazine et leurs préparations |
JPS606946B2 (ja) * | 1974-03-12 | 1985-02-21 | 東京田辺製薬株式会社 | N−(3,3−ジフエニルプロピル)−n’−アラルキル置換ピペラジンおよびその塩の製法 |
-
1978
- 1978-04-27 IT IT67951/78A patent/IT1156989B/it active
-
1979
- 1979-04-03 GR GR58768A patent/GR68530B/el unknown
- 1979-04-12 GB GB7912963A patent/GB2020274B/en not_active Expired
- 1979-04-17 ES ES479627A patent/ES479627A1/es not_active Expired
- 1979-04-19 NL NL7903062A patent/NL7903062A/xx not_active Application Discontinuation
- 1979-04-21 JP JP4961179A patent/JPS54154777A/ja active Pending
- 1979-04-24 PT PT69540A patent/PT69540A/pt unknown
- 1979-04-25 FR FR7910524A patent/FR2424263A1/fr active Granted
- 1979-04-26 CH CH391279A patent/CH638192A5/it not_active IP Right Cessation
- 1979-04-26 DE DE2916991A patent/DE2916991C3/de not_active Expired
- 1979-04-26 BE BE0/194864A patent/BE875886A/xx not_active IP Right Cessation
- 1979-04-27 US US06/034,040 patent/US4264770A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037077A1 (en) * | 1997-02-24 | 1998-08-27 | Zymogenetics, Inc. | Calcitonin mimetics |
Also Published As
Publication number | Publication date |
---|---|
GB2020274A (en) | 1979-11-14 |
NL7903062A (nl) | 1979-10-30 |
GB2020274B (en) | 1982-08-25 |
CH638192A5 (it) | 1983-09-15 |
US4264770A (en) | 1981-04-28 |
IT7867951A0 (it) | 1978-04-27 |
GR68530B (es) | 1982-01-14 |
DE2916991B2 (de) | 1980-05-29 |
JPS54154777A (en) | 1979-12-06 |
IT1156989B (it) | 1987-02-04 |
PT69540A (en) | 1979-05-01 |
DE2916991C3 (de) | 1981-02-05 |
DE2916991A1 (de) | 1979-10-31 |
BE875886A (fr) | 1979-08-16 |
FR2424263A1 (fr) | 1979-11-23 |
FR2424263B1 (es) | 1983-02-11 |
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